HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: FILA (P20930)
Filaggrin
Gene: FLG

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31324722
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 4061
+	Hs
		529220 CFTR_HUMAN (1-1480): 0: 1031: 100.00		FILA2_HUMAN (1661-4000): 4.12e-60: 233: 20.51
+	Hs
		529371 CFTR_HUMAN (1-1480): 0: 1031: 100.00		HORN_HUMAN (2054-4025): 1.48e-58: 228: 17.22
+	Hs
		441051 CFTR_HUMAN (1-1480): 0: 1031: 100.00		CO4A2_HUMAN (3241-4046): 4.47e-44: 180: 8.51
+	Hs
		528867 CFTR_HUMAN (1-1480): 0: 1031: 100.00		S10AA_HUMAN (2-100): 1.31e-42: 153: 26.26
+	Hs
		528643 CFTR_HUMAN (1-1480): 0: 1031: 100.00		S10AB_HUMAN (2-102): 4.49e-42: 152: 30.69
+	Hs
		416344 CFTR_HUMAN (1-1480): 0: 1031: 100.00		S10A9_HUMAN (1-102): 2.02e-40: 148: 35.92
+	Hs
		396673 CFTR_HUMAN (1-1480): 0: 1031: 100.00		S10A8_HUMAN (1-95): 1.16e-36: 136: 27.37
+	Hs
		416559 CFTR_HUMAN (1-1480): 0: 1031: 100.00		S10A6_HUMAN (4-89): 2.76e-19: 87: 32.56