HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: DNJB1 (P25685)
DnaJ homolog subfamily B member 1 (DnaJ protein homolog 1) (Heat shock 40 kDa protein 1) (HSP40) (Heat shock protein 40) (Human DnaJ protein 1) (hDj-1)
Gene: DNAJB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	26618866, 10075921, 17110338
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0051087 - protein-folding chaperone binding
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 340
+	Hs
		279273 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DNJB5_HUMAN (1-339): 3.31e-126: 366: 59.71
+	Hs
		528635 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DNJA1_HUMAN (5-339): 2.97e-117: 346: 32.77
+	Hs
		243278 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DNJA2_HUMAN (2-339): 2.35e-115: 341: 33.24
+	Hs
		529849 CFTR_HUMAN (1-1480): 0: 1031: 100.00		DJB11_HUMAN (2-338): 8.5e-105: 313: 32.26
+	Sc
		633231 YCFI_YEAST (748-1433): 4.8e-56: 216: 14.59		MAS5_YEAST (5-339): 5.57e-109: 325: 31.29