HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: XPO2 (P55060)
Exportin-2 (Exp2) (Cellular apoptosis susceptibility protein) (Chromosome segregation 1-like protein) (Importin-alpha re-exporter)
Gene: CSE1L

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.650

Property	Details
Experiments	31324722, 17110338, 29924966
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 971
+	Hs
		178097 CFTR_HUMAN (1-1480): 0: 1031: 100.00		IPO8_HUMAN (7-962): 1.26e-161: 503: 18.13
+	Hs
		312172 CFTR_HUMAN (1-1480): 0: 1031: 100.00		IPO7_HUMAN (7-880): 9.51e-158: 493: 19.02
+	Hs
		529511 CFTR_HUMAN (1-1480): 0: 1031: 100.00		TNPO1_HUMAN (2-861): 1.05e-127: 410: 13.35
+	Hs
		529873 CFTR_HUMAN (1-1480): 0: 1031: 100.00		IPO11_HUMAN (1-966): 7.87e-116: 380: 15.29
+	Hs
		529589 CFTR_HUMAN (1-1480): 0: 1031: 100.00		IPO9_HUMAN (8-923): 1.04e-112: 373: 14.79
+	Hs
		127173 CFTR_HUMAN (1-1480): 0: 1031: 100.00		IPO5_HUMAN (90-886): 1.85e-18: 93.4: 11.41
+	Dm
		1182055 Q7KTD0_DROME (788-1466): 6.87e-53: 206: 14.95		Q9VSD6_DROME (7-930): 2.96e-147: 466: 18.10
+	Dm
		1182040 Q7KTD0_DROME (788-1466): 6.87e-53: 206: 14.95		IPO9_DROME (5-869): 2.55e-118: 388: 13.82