HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: GNAS2 (P63092)
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (Adenylate cyclase-stimulating G alpha protein)
Gene: GNAS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.636

Property	Details
Experiments	35156780, 31324722, 29924966
Identification Methods	protein complementation assay, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 394
+	Hs
		529225 CFTR_HUMAN (1-1480): 0: 1031: 100.00		GNAS1_HUMAN (11-394): 6.95e-170: 503: 95.05
+	Hs
		391317 CFTR_HUMAN (1-1480): 0: 1031: 100.00		GNAI2_HUMAN (1-394): 1.99e-158: 451: 38.83
+	Hs
		444657 CFTR_HUMAN (1-1480): 0: 1031: 100.00		GNAI3_HUMAN (1-394): 1.06e-155: 444: 38.58
+	Hs
		528614 CFTR_HUMAN (1-1480): 0: 1031: 100.00		GNA11_HUMAN (11-394): 1.04e-146: 421: 38.80
+	Hs
		528513 CFTR_HUMAN (1-1480): 0: 1031: 100.00		GNAZ_HUMAN (1-393): 2.98e-142: 410: 37.15