HitPredict

Interactor 1: CFTR (P13569)
Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)
Gene: CFTR

Interactor 2: RACK1 (P63244)
Small ribosomal subunit protein RACK1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Receptor of activated protein C kinase 1) [Cleaved into: Small ribosomal subunit protein RACK1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed) (Receptor of activated protein C kinase 1, N-terminally processed)]
Gene: RACK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.691

Property	Details
Experiments	26618866, 31324722, 17110338, 29924966
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019899 - enzyme binding
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 1480 Hs			1 317
+	Hs
		529361 CFTR_HUMAN (1-1480): 0: 1031: 100.00		WDR5B_HUMAN (3-177): 1.1e-41: 148: 24.31
+	Hs
		706697 MRP1_HUMAN (810-1471): 5.31e-60: 229: 15.70		WDR5_HUMAN (3-219): 3.42e-62: 202: 26.70
+	Sc
		742801 YCFI_YEAST (748-1433): 4.8e-56: 216: 14.59		GBLP_YEAST (5-138): 5.08e-18: 84.6: 19.68