HitPredict

Interactor 1: TRI27 (P14373)
Zinc finger protein RFP (EC 2.3.2.27) (RING finger protein 76) (Ret finger protein) (Tripartite motif-containing protein 27)
Gene: TRIM27

Interactor 2: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	29656893
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	zf-B_box~zf-C3HC4
Common GO terms	GO:0003677 - DNA binding GO:0003713 - transcription coactivator activity GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005654 - nucleoplasm and 2 others more... GO:0005737 - cytoplasm GO:0008270 - zinc ion binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 513 Hs			1 1863
+	Hs
		536980 TRI27_HUMAN (1-513): 0: 523: 100.00		TRI11_HUMAN (11-390): 3.9e-74: 257: 11.49
+	Hs
		536717 TRI27_HUMAN (1-513): 0: 523: 100.00		TRI27_HUMAN (13-390): 9.61e-69: 243: 11.74
+	Hs
		536726 TRI27_HUMAN (1-513): 0: 523: 100.00		RO52_HUMAN (15-390): 2.55e-68: 241: 12.86
+	Hs
		536970 TRI27_HUMAN (1-513): 0: 523: 100.00		TRI43_HUMAN (12-324): 9.24e-67: 235: 12.62
+	Hs
		584870 RO52_HUMAN (1-500): 2.33e-160: 465: 36.78		RO52_HUMAN (15-390): 2.55e-68: 241: 12.86
+	Hs
		585075 RO52_HUMAN (1-500): 2.33e-160: 465: 36.78		TRI39_HUMAN (15-389): 8.42e-67: 238: 13.19
+	Hs
		1336382 TRI39_HUMAN (7-494): 3.22e-158: 462: 37.60		TRI39_HUMAN (15-389): 8.42e-67: 238: 13.19
+	Hs
		585058 RO52_HUMAN (1-500): 2.33e-160: 465: 36.78		TRIM5_HUMAN (10-339): 1.37e-63: 227: 13.27
+	Hs
		1290865 TRI11_HUMAN (1-500): 9.03e-148: 433: 38.00		TRI11_HUMAN (11-390): 3.9e-74: 257: 11.49
+	Hs
		1336392 TRI39_HUMAN (7-494): 3.22e-158: 462: 37.60		TRI17_HUMAN (10-327): 9.61e-62: 221: 11.85
+	Hs
		1149881 TRI68_HUMAN (1-496): 2.82e-143: 422: 34.96		TRI68_HUMAN (12-388): 1.67e-74: 259: 11.31
+	Mm
		1112402 RO52_MOUSE (3-492): 8.38e-148: 433: 34.55		Q3U7K7_MOUSE (14-409): 1.12e-67: 238: 13.40
+	Hs
		1245269 TRI58_HUMAN (1-493): 2.59e-145: 427: 34.00		TRI58_HUMAN (16-390): 3.39e-69: 243: 12.53
+	Hs
		537046 TRI27_HUMAN (1-513): 0: 523: 100.00		TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30
+	Hs
		1290900 TRI11_HUMAN (1-500): 9.03e-148: 433: 38.00		TRI10_HUMAN (12-342): 2.46e-55: 203: 13.97
+	Hs
		585057 RO52_HUMAN (1-500): 2.33e-160: 465: 36.78		TRI31_HUMAN (15-120): 1.69e-29: 125: 28.30