HitPredict

Interactor 1: INSRR (P14616)
Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]
Gene: INSRR

Interactor 2: VRK2 (Q86Y07)
Serine/threonine-protein kinase VRK2 (EC 2.7.11.1) (Vaccinia-related kinase 2)
Gene: VRK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0046777 - protein autophosphorylation
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 1297 Hs			1 508
+	Hs
		411424 INSR_HUMAN (27-1288): 0: 1183: 52.18		VRK2_HUMAN (1-508): 1.87e-117: 357: 100.00
+	Hs
		411417 INSR_HUMAN (27-1288): 0: 1183: 52.18		MARK2_HUMAN (3-485): 1.13e-111: 350: 13.73
+	Hs
		647831 EPHB2_HUMAN (455-1264): 0: 605: 19.86		MARK3_HUMAN (22-469): 8.37e-112: 350: 14.22
+	Hs
		665494 EPHA8_HUMAN (454-1268): 2.42e-179: 558: 20.16		VRK2_HUMAN (1-508): 1.87e-117: 357: 100.00
+	Hs
		568557 EPHA2_HUMAN (455-1282): 9.77e-179: 556: 21.20		KAPCA_HUMAN (17-370): 7.42e-110: 331: 13.45
+	Hs
		600512 EPHA1_HUMAN (657-1279): 2.19e-159: 505: 23.51		MARK3_HUMAN (22-469): 8.37e-112: 350: 14.22
+	Hs
		665205 EPHA2_HUMAN (455-1282): 9.77e-179: 556: 21.20		KC1G2_HUMAN (24-392): 2.53e-96: 299: 22.25
+	Hs
		169186 MUSK_HUMAN (973-1242): 8.31e-67: 245: 42.61		VRK2_HUMAN (1-508): 1.87e-117: 357: 100.00
+	Hs
		647902 NTRK2_HUMAN (957-1253): 1.12e-67: 247: 42.43		MARK3_HUMAN (22-469): 8.37e-112: 350: 14.22
+	Hs
		384307 NTRK1_HUMAN (957-1247): 1.28e-65: 240: 42.91		MARK3_HUMAN (22-469): 8.37e-112: 350: 14.22
+	Hs
		385052 NTRK1_HUMAN (957-1247): 1.28e-65: 240: 42.91		MARK2_HUMAN (3-485): 1.13e-111: 350: 13.73
+	Hs
		1081524 NTRK3_HUMAN (957-1242): 2.05e-62: 231: 40.84		VRK2_HUMAN (1-508): 1.87e-117: 357: 100.00
+	Hs
		384487 NTRK1_HUMAN (957-1247): 1.28e-65: 240: 42.91		KC1E_HUMAN (21-455): 3.27e-110: 335: 23.06
+	Hs
		507867 FGFR1_HUMAN (948-1294): 6.81e-59: 221: 35.90		MARK3_HUMAN (22-469): 8.37e-112: 350: 14.22
+	Hs
		384472 NTRK1_HUMAN (957-1247): 1.28e-65: 240: 42.91		KC1A_HUMAN (17-366): 5.32e-106: 321: 24.72
+	Hs
		507838 FGFR1_HUMAN (948-1294): 6.81e-59: 221: 35.90		KAPCA_HUMAN (17-370): 7.42e-110: 331: 13.45
+	Hs
		507947 FGFR1_HUMAN (948-1294): 6.81e-59: 221: 35.90		KC1G2_HUMAN (24-392): 2.53e-96: 299: 22.25
+	Hs
		568539 ERBB3_HUMAN (2-296): 3.16e-34: 145: 18.24		KAPCA_HUMAN (17-370): 7.42e-110: 331: 13.45