HitPredict

Interactor 1: ENPL (P14625)
Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog)
Gene: HSP90B1

Interactor 2: KPCA (P17252)
Protein kinase C alpha type (PKC-A) (PKC-alpha) (EC 2.7.11.13)
Gene: PRKCA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22519731
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005783 - endoplasmic reticulum GO:0005829 - cytosol GO:0048471 - perinuclear region of cytoplasm GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 803 Hs			1 672
+	Hs
		437869 HS90B_HUMAN (75-783): 0: 997: 46.54		KPCA_HUMAN (1-672): 0: 794: 100.00
+	Hs
		408529 HS90B_HUMAN (75-783): 0: 997: 46.54		KPCB_HUMAN (1-664): 0: 749: 78.89
+	Hs
		408527 HS90A_HUMAN (60-783): 0: 990: 45.34		KPCB_HUMAN (1-664): 0: 749: 78.89
+	Hs
		397124 HS90B_HUMAN (75-783): 0: 997: 46.54		KPCG_HUMAN (1-670): 0: 706: 68.94
+	Hs
		397123 HS90A_HUMAN (60-783): 0: 990: 45.34		KPCG_HUMAN (1-670): 0: 706: 68.94
+	Hs
		438085 HS90B_HUMAN (75-783): 0: 997: 46.54		KPCE_HUMAN (8-664): 0: 635: 44.61
+	Hs
		538446 ENPL_HUMAN (1-803): 0: 1073: 100.00		AKT3_HUMAN (283-660): 6.86e-156: 460: 40.46
+	Hs
		538122 ENPL_HUMAN (1-803): 0: 1073: 100.00		AKT1_HUMAN (243-660): 2.07e-155: 459: 37.36
+	Bt
		964601 HS90B_BOVIN (75-783): 0: 997: 46.68		AKT1_BOVIN (243-660): 1.03e-156: 462: 38.50
+	Hs
		438633 HS90B_HUMAN (75-783): 0: 997: 46.54		AKT3_HUMAN (283-660): 6.86e-156: 460: 40.46
+	Mm
		513660 HS90B_MOUSE (75-783): 0: 998: 46.26		AKT1_MOUSE (243-660): 1.45e-155: 459: 37.36
+	Hs
		437927 HS90B_HUMAN (75-783): 0: 997: 46.54		AKT1_HUMAN (243-660): 2.07e-155: 459: 37.36
+	Hs
		437928 HS90B_HUMAN (75-783): 0: 997: 46.54		AKT2_HUMAN (242-660): 9.73e-156: 459: 39.13
+	Hs
		116958 HS90B_HUMAN (75-783): 0: 997: 46.54		SGK1_HUMAN (255-661): 1.16e-153: 452: 38.85
+	Hs
		116956 HS90A_HUMAN (60-783): 0: 990: 45.34		SGK1_HUMAN (255-661): 1.16e-153: 452: 38.85
+	Hs
		438094 HS90B_HUMAN (75-783): 0: 997: 46.54		KPCT_HUMAN (18-155): 9.83e-54: 198: 45.52
+	Hs
		437907 HS90B_HUMAN (75-783): 0: 997: 46.54		KPCL_HUMAN (31-215): 2e-49: 185: 35.57
+	Hs
		538205 ENPL_HUMAN (1-803): 0: 1073: 100.00		KPCZ_HUMAN (22-98): 3.2e-11: 68.6: 34.44
+	Hs
		437962 HS90B_HUMAN (75-783): 0: 997: 46.54		KPCI_HUMAN (22-86): 8.63e-12: 70.1: 43.08
+	Hs
		438097 HS90B_HUMAN (75-783): 0: 997: 46.54		KPCZ_HUMAN (22-98): 3.2e-11: 68.6: 34.44