HitPredict

Interactor 1: ENPL (P14625)
Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog)
Gene: HSP90B1

Interactor 2: KAPCB (P22694)
cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11)
Gene: PRKACB

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34349018
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 803 Hs			1 351
+	Hs
		538446 ENPL_HUMAN (1-803): 0: 1073: 100.00		AKT3_HUMAN (4-347): 2.95e-148: 428: 38.57
+	Hs
		538122 ENPL_HUMAN (1-803): 0: 1073: 100.00		AKT1_HUMAN (2-347): 4.4e-147: 425: 39.03
+	Hs
		437900 HS90B_HUMAN (75-783): 0: 997: 46.54		KAPCB_HUMAN (1-351): 1.47e-164: 464: 100.00
+	Hs
		437870 HS90B_HUMAN (75-783): 0: 997: 46.54		KAPCA_HUMAN (1-351): 3.72e-164: 463: 92.88
+	Hs
		70435 HS90A_HUMAN (60-783): 0: 990: 45.34		B2RB89_HUMAN (1-351): 1.47e-164: 464: 100.00
+	Hs
		437898 HS90B_HUMAN (75-783): 0: 997: 46.54		KAPCG_HUMAN (1-351): 5.62e-161: 456: 78.63
+	Hs
		437928 HS90B_HUMAN (75-783): 0: 997: 46.54		AKT2_HUMAN (5-347): 1.05e-149: 432: 37.46
+	Hs
		437907 HS90B_HUMAN (75-783): 0: 997: 46.54		KPCL_HUMAN (6-351): 1.63e-146: 430: 35.75
+	Hs
		438633 HS90B_HUMAN (75-783): 0: 997: 46.54		AKT3_HUMAN (4-347): 2.95e-148: 428: 38.57
+	Mm
		513660 HS90B_MOUSE (75-783): 0: 998: 46.26		AKT1_MOUSE (2-347): 8.96e-148: 427: 39.32
+	Bt
		964601 HS90B_BOVIN (75-783): 0: 997: 46.68		AKT1_BOVIN (2-347): 2.7e-148: 428: 39.60
+	Hs
		437927 HS90B_HUMAN (75-783): 0: 997: 46.54		AKT1_HUMAN (2-347): 4.4e-147: 425: 39.03
+	Hs
		438085 HS90B_HUMAN (75-783): 0: 997: 46.54		KPCE_HUMAN (3-351): 3.98e-140: 416: 34.25
+	Hs
		116958 HS90B_HUMAN (75-783): 0: 997: 46.54		SGK1_HUMAN (1-348): 5.91e-143: 413: 37.71
+	Hs
		438013 HS90B_HUMAN (75-783): 0: 997: 46.54		PRKX_HUMAN (8-351): 7.27e-144: 412: 49.13
+	Hs
		438585 HS90B_HUMAN (75-783): 0: 997: 46.54		KS6B2_HUMAN (26-351): 1.5e-141: 411: 37.17
+	Hs
		437905 HS90B_HUMAN (75-783): 0: 997: 46.54		KS6B1_HUMAN (23-351): 1.44e-140: 410: 36.55
+	Hs
		438541 HS90B_HUMAN (75-783): 0: 997: 46.54		SGK2_HUMAN (35-340): 1.82e-137: 396: 42.44
+	Hs
		217856 HS90B_HUMAN (75-783): 0: 997: 46.54		PRKY_HUMAN (41-267): 4.53e-93: 280: 54.63
+	Hs
		438131 HS90B_HUMAN (75-783): 0: 997: 46.54		KGP2_HUMAN (37-334): 2.14e-85: 275: 44.70