Protein: CHD5
Chromodomain-helicase-DNA-binding protein 5 (CHD-5) (EC 3.6.4.-) (ATP-dependent helicase CHD5)

Gene: CHD5
Organism: Homo sapiens
Interactions: 77
UniProt ID: Q8TDI0

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000792 - heterochromatin
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0004386 - helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1158933

RBBP7
Histone-binding protein RBBP7

5

20

Small-scale

0.919

High

1132848

CHD4
Chromodomain-helicase-DNA-binding protein 4

5

13

Small-scale

0.906

High

1109925

HDAC1
Histone deacetylase 1

4

20

Small-scale

0.892

High

1066410

RBBP4
Histone-binding protein RBBP4

3

20

Small-scale

0.839

High

1088469

CHD3
Chromodomain-helicase-DNA-binding protein 3

3

16

High-throughput

0.827

High

1097444

CBX3
Chromobox protein homolog 3

2

19

Small-scale

0.776

High

316925

MTA2
Metastasis-associated protein MTA2

2

20

Small-scale

0.754

High

1351284

MTA3
Metastasis-associated protein MTA3

2

20

Small-scale

0.754

High

1351276

P66B
Transcriptional repressor p66-beta

5

13

Small-scale

0.714

High

1351290

ZN219
Zinc finger protein 219

4

2

High-throughput

0.694

High

1295270

P66A
Transcriptional repressor p66-alpha

3

13

Small-scale

0.667

High

155329

CDKA1
Cyclin-dependent kinase 2-associated protein 1

3

9

High-throughput

0.650

High

256932

H2B1K
Histone H2B type 1-K

1

20

High-throughput

0.618

High

273439

KDM4A
Lysine-specific demethylase 4A

1

6

Small-scale

0.618

High

274356

SIN3B
Paired amphipathic helix protein Sin3b

1

10

High-throughput

0.618

High

342266

BRD1
Bromodomain-containing protein 1

1

19

Small-scale

0.618

High

937302

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

18

High-throughput

0.618

High

980946

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.618

High

998577

H31
Histone H3.1

1

20

High-throughput

0.618

High

1008813

RED1
Double-stranded RNA-specific editase 1

1

20

High-throughput

0.618

High

1086794

BPTF
Nucleosome-remodeling factor subunit BPTF

1

20

High-throughput

0.618

High

1102607

MTA1
Metastasis-associated protein MTA1

1

20

Small-scale

0.618

High

1135258

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

16

High-throughput

0.618

High

1161955

H31T
Histone H3.1t

1

20

Small-scale

0.618

High

1195572

ARI4B
AT-rich interactive domain-containing protein 4B

1

15

High-throughput

0.618

High

1351274

PHIP
PH-interacting protein

1

20

Small-scale

0.618

High

1351278

HDAC2
Histone deacetylase 2

1

20

Small-scale

0.618

High

1351282

PHF12
PHD finger protein 12

1

17

High-throughput

0.618

High

1351283

MEP50
Methylosome protein WDR77

1

16

High-throughput

0.618

High

1351294

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

1

20

High-throughput

0.618

High

1351285

BC11B
B-cell lymphoma/leukemia 11B

2

10

High-throughput

0.611

High

1351291

MBD2
Methyl-CpG-binding domain protein 2

2

18

Small-scale

0.584

High

142376

PEX7
Peroxisomal targeting signal 2 receptor

1

20

High-throughput

0.575

High

352202

MBD3
Methyl-CpG-binding domain protein 3

2

18

Small-scale

0.571

High

473448

HCK
Tyrosine-protein kinase HCK

2

6

High-throughput

0.571

High

363602

EGFR
Epidermal growth factor receptor

2

2

High-throughput

0.565

High

347201

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.536

High

931019

HSP72
Heat shock-related 70 kDa protein 2

1

6

High-throughput

0.536

High

1094787

CAF1B
Chromatin assembly factor 1 subunit B

1

11

High-throughput

0.536

High

1235071

ADNP2
Activity-dependent neuroprotector homeobox protein 2

1

9

High-throughput

0.536

High

1340891

MB3L2
Methyl-CpG-binding domain protein 3-like 2

1

18

High-throughput

0.536

High

1351275

MB3L1
Methyl-CpG-binding domain protein 3-like 1

1

18

High-throughput

0.536

High

186341

RA51B
DNA repair protein RAD51 homolog 2

1

3

High-throughput

0.479

High

223202

PRC1
Protein regulator of cytokinesis 1

1

4

High-throughput

0.479

High

239972

SOX15
Transcription factor SOX-15

1

20

High-throughput

0.479

High

282276

SAP30
Histone deacetylase complex subunit SAP30

1

4

High-throughput

0.479

High

299485

CDKA2
Cyclin-dependent kinase 2-associated protein 2

1

9

Small-scale

0.479

High

325000

HEXI1
Protein HEXIM1

1

3

High-throughput

0.479

High

372655

MYC
Myc proto-oncogene protein

1

19

High-throughput

0.479

High

519532

MYBB
Myb-related protein B

1

10

High-throughput

0.479

High

778084

VGFR2
Vascular endothelial growth factor receptor 2

1

6

High-throughput

0.479

High

920134

PLK1
Serine/threonine-protein kinase PLK1

1

8

High-throughput

0.479

High

939639

BID
BH3-interacting domain death agonist

1

1

Small-scale

0.479

High

1137880

TNIP1
TNFAIP3-interacting protein 1

1

17

High-throughput

0.479

High

1208621

BRM1L
Breast cancer metastasis-suppressor 1-like protein

1

9

High-throughput

0.479

High

1216611

LIN9
Protein lin-9 homolog

1

4

High-throughput

0.479

High

1308672

DYH10
Dynein axonemal heavy chain 10

1

1

High-throughput

0.479

High

1312673

BAP18
BPTF-associated chromatin complex component 1

1

4

High-throughput

0.479

High

1328874

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

8

High-throughput

0.479

High

1351277

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

1

High-throughput

0.479

High

1351280

LIN37
Protein lin-37 homolog

1

4

High-throughput

0.479

High

1351281

PWP2A
PWWP domain-containing protein 2A

1

10

High-throughput

0.479

High

1351286

SP130
Histone deacetylase complex subunit SAP130

1

8

High-throughput

0.479

High

1351287

BC11A
BCL11 transcription factor A

1

10

High-throughput

0.479

High

1351288

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

9

High-throughput

0.479

High

1351289

ANLN
Anillin

1

2

High-throughput

0.479

High

1351292

HMGX4
HMG domain-containing protein 4

1

20

High-throughput

0.479

High

1351295

TR150
Thyroid hormone receptor-associated protein 3

1

13

High-throughput

0.479

High

459690

PROF1
Profilin-1

1

0

High-throughput

0.458

High

1229003

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.458

High

330250

VENTX
Homeobox protein VENTX

1

10

High-throughput

0.445

High

625519

CSK22
Casein kinase II subunit alpha'

1

8

High-throughput

0.445

High

911015

IMA1
Importin subunit alpha-1

1

20

High-throughput

0.445

High

911319

IMA5
Importin subunit alpha-5

1

20

High-throughput

0.445

High

1099737

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

3

High-throughput

0.445

High

1351279

STMN2
Stathmin-2

1

2

High-throughput

0.445

High

1351293

TRPS1
Zinc finger transcription factor Trps1

1

20

High-throughput

0.445

High


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Last updated: 11Aug2025