HitPredict

Interactor 1: ENPL (P14625)
Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Heat shock protein family C member 4) (Tumor rejection antigen 1) (gp96 homolog)
Gene: HSP90B1

Interactor 2: AKT3 (Q9Y243)
RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) (STK-2)
Gene: AKT3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34349018
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 803 Hs			1 479
+	Hs
		538122 ENPL_HUMAN (1-803): 0: 1073: 100.00		AKT1_HUMAN (1-477): 0: 558: 82.29
+	Hs
		438633 HS90B_HUMAN (75-783): 0: 997: 46.54		AKT3_HUMAN (1-479): 0: 589: 100.00
+	Mm
		513660 HS90B_MOUSE (75-783): 0: 998: 46.26		AKT1_MOUSE (1-477): 0: 562: 82.08
+	Hs
		437928 HS90B_HUMAN (75-783): 0: 997: 46.54		AKT2_HUMAN (1-479): 0: 561: 75.78
+	Bt
		964601 HS90B_BOVIN (75-783): 0: 997: 46.68		AKT1_BOVIN (1-476): 0: 561: 81.84
+	Hs
		437927 HS90B_HUMAN (75-783): 0: 997: 46.54		AKT1_HUMAN (1-477): 0: 558: 82.29
+	Hs
		538091 ENPL_HUMAN (1-803): 0: 1073: 100.00		KPCA_HUMAN (13-476): 6.53e-152: 449: 36.75
+	Hs
		437869 HS90B_HUMAN (75-783): 0: 997: 46.54		KPCA_HUMAN (13-476): 6.53e-152: 449: 36.75
+	Hs
		437907 HS90B_HUMAN (75-783): 0: 997: 46.54		KPCL_HUMAN (110-476): 8.45e-151: 447: 41.73
+	Hs
		438085 HS90B_HUMAN (75-783): 0: 997: 46.54		KPCE_HUMAN (52-473): 1.57e-148: 443: 41.41
+	Hs
		408529 HS90B_HUMAN (75-783): 0: 997: 46.54		KPCB_HUMAN (13-476): 3.8e-149: 442: 36.94
+	Hs
		437905 HS90B_HUMAN (75-783): 0: 997: 46.54		KS6B1_HUMAN (89-477): 4.14e-149: 437: 38.68
+	Hs
		438094 HS90B_HUMAN (75-783): 0: 997: 46.54		KPCT_HUMAN (85-479): 8.26e-147: 437: 39.39
+	Hs
		438422 HS90B_HUMAN (75-783): 0: 997: 46.54		SGK3_HUMAN (61-479): 4.68e-149: 436: 42.35
+	Hs
		438585 HS90B_HUMAN (75-783): 0: 997: 46.54		KS6B2_HUMAN (105-477): 1.09e-148: 434: 40.05
+	Hs
		116958 HS90B_HUMAN (75-783): 0: 997: 46.54		SGK1_HUMAN (100-477): 4.38e-147: 428: 45.12
+	Hs
		438541 HS90B_HUMAN (75-783): 0: 997: 46.54		SGK2_HUMAN (117-474): 5.54e-146: 423: 48.07
+	Hs
		438193 HS90B_HUMAN (75-783): 0: 997: 46.54		KS6A1_HUMAN (54-459): 5.85e-103: 325: 21.91
+	Hs
		438011 HS90B_HUMAN (75-783): 0: 997: 46.54		KS6A3_HUMAN (146-418): 7.07e-101: 320: 28.52
+	Hs
		437962 HS90B_HUMAN (75-783): 0: 997: 46.54		KPCI_HUMAN (118-473): 3.27e-101: 317: 43.94