HitPredict

Interactor 1: CCNB1 (P14635)
G2/mitotic-specific cyclin-B1
Gene: CCNB1

Interactor 2: CKS2 (P33552)
Cyclin-dependent kinases regulatory subunit 2 (CKS-2)
Gene: CKS2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.735

Property	Details
Experiments	26496610, 30674583, 18471975, 28514442, 33961781, 19786724
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0019901 - protein kinase binding GO:0044772 - mitotic cell cycle phase transition GO:0051301 - cell division GO:0061575 - cyclin-dependent protein serine/threonine kinase activator activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 433 Hs			1 79
+	Hs
		538505 CCNB1_HUMAN (1-433): 6.07e-159: 457: 100.00		CKS1_HUMAN (1-79): 1.09e-39: 127: 81.01
+	At
		1352139 CCB24_ARATH (7-423): 9.76e-120: 357: 27.59		CKS2_ARATH (5-78): 2.49e-39: 126: 66.22
+	At
		188178 CCB24_ARATH (7-423): 9.76e-120: 357: 27.59		CKS1_ARATH (5-73): 5.91e-38: 123: 68.12
+	Hs
		303840 CCNB2_HUMAN (16-430): 8.52e-118: 351: 48.56		CKS1_HUMAN (1-79): 1.09e-39: 127: 81.01
+	Hs
		895411 CCNA1_HUMAN (21-424): 6.91e-117: 351: 27.70		CKS1_HUMAN (1-79): 1.09e-39: 127: 81.01
+	Hs
		303832 CCNB2_HUMAN (16-430): 8.52e-118: 351: 48.56		CKS2_HUMAN (1-79): 8.58e-38: 122: 100.00
+	Hs
		706795 CCNA1_HUMAN (21-424): 6.91e-117: 351: 27.70		CKS2_HUMAN (1-79): 8.58e-38: 122: 100.00
+	At
		188148 CCA23_ARATH (7-423): 4.19e-115: 346: 28.11		CKS1_ARATH (5-73): 5.91e-38: 123: 68.12
+	At
		1106919 CCB12_ARATH (11-422): 1.24e-112: 339: 29.66		CKS2_ARATH (5-78): 2.49e-39: 126: 66.22
+	Hs
		590156 CCNA2_HUMAN (9-421): 3.65e-112: 338: 29.12		CKS1_HUMAN (1-79): 1.09e-39: 127: 81.01
+	At
		188149 CCB12_ARATH (11-422): 1.24e-112: 339: 29.66		CKS1_ARATH (5-73): 5.91e-38: 123: 68.12
+	Hs
		590135 CCNA2_HUMAN (9-421): 3.65e-112: 338: 29.12		CKS2_HUMAN (1-79): 8.58e-38: 122: 100.00
+	At
		188167 CCB23_ARATH (9-422): 2.46e-111: 335: 25.58		CKS1_ARATH (5-73): 5.91e-38: 123: 68.12
+	Dm
		540500 CCNA_DROME (1-421): 9.47e-103: 315: 25.00		Q9VHN1_DROME (1-71): 3.94e-38: 123: 69.01
+	At
		1324477 CCA31_ARATH (75-427): 7.25e-103: 311: 31.51		CKS2_ARATH (5-78): 2.49e-39: 126: 66.22
+	At
		188134 CCB14_ARATH (30-424): 1.75e-102: 311: 31.66		CKS1_ARATH (5-73): 5.91e-38: 123: 68.12
+	Dm
		540479 CCNA_DROME (1-421): 9.47e-103: 315: 25.00		CKS1_DROME (3-72): 1.5e-35: 116: 77.14
+	At
		48925 CCA33_ARATH (125-426): 1.04e-100: 305: 37.22		CKS1_ARATH (5-73): 5.91e-38: 123: 68.12
+	Sc
		594110 CG22_YEAST (5-416): 1.45e-101: 312: 30.36		CKS1_YEAST (4-78): 2.01e-33: 113: 48.81
+	Sc
		594112 CG24_YEAST (38-417): 4.54e-100: 308: 27.14		CKS1_YEAST (4-78): 2.01e-33: 113: 48.81