HitPredict

Interactor 1: YAK1 (P14680)
Dual specificity protein kinase YAK1 (EC 2.7.12.1)
Gene: YAK1

Interactor 2: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	37295430
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 807 Sc			1 705
+	Hs
		408529 KPCB_HUMAN (170-678): 9.9e-123: 385: 16.89		HS90B_HUMAN (5-705): 0: 1022: 61.15
+	Hs
		437928 AKT2_HUMAN (249-666): 3.18e-125: 385: 15.14		HS90B_HUMAN (5-705): 0: 1022: 61.15
+	Hs
		438633 AKT3_HUMAN (259-697): 1.64e-124: 384: 17.14		HS90B_HUMAN (5-705): 0: 1022: 61.15
+	Hs
		437869 KPCA_HUMAN (174-679): 6.25e-122: 383: 16.41		HS90B_HUMAN (5-705): 0: 1022: 61.15
+	Mm
		513660 AKT1_MOUSE (266-670): 3.71e-123: 380: 15.88		HS90B_MOUSE (5-705): 0: 1025: 61.57
+	Bt
		964601 AKT1_BOVIN (249-670): 9.04e-124: 382: 15.95		HS90B_BOVIN (5-705): 0: 1022: 61.15
+	Hs
		437927 AKT1_HUMAN (266-670): 9.7e-123: 379: 16.11		HS90B_HUMAN (5-705): 0: 1022: 61.15
+	Hs
		408527 KPCB_HUMAN (170-678): 9.9e-123: 385: 16.89		HS90A_HUMAN (4-705): 0: 1013: 60.67
+	Hs
		431573 AKT2_HUMAN (249-666): 3.18e-125: 385: 15.14		HS90A_HUMAN (4-705): 0: 1013: 60.67
+	Hs
		432376 AKT3_HUMAN (259-697): 1.64e-124: 384: 17.14		HS90A_HUMAN (4-705): 0: 1013: 60.67
+	Hs
		431510 KPCA_HUMAN (174-679): 6.25e-122: 383: 16.41		HS90A_HUMAN (4-705): 0: 1013: 60.67
+	Rn
		812703 AKT1_RAT (265-670): 2.87e-123: 380: 15.84		HS90A_RAT (4-705): 0: 1014: 60.59
+	Hs
		438155 DYR1A_HUMAN (247-807): 2.62e-116: 371: 27.67		HS90B_HUMAN (5-705): 0: 1022: 61.15
+	Hs
		431572 AKT1_HUMAN (266-670): 9.7e-123: 379: 16.11		HS90A_HUMAN (4-705): 0: 1013: 60.67
+	Mm
		432411 AKT1_MOUSE (266-670): 3.71e-123: 380: 15.88		HS90A_MOUSE (4-705): 0: 1012: 60.59
+	Hs
		431834 DYR1A_HUMAN (247-807): 2.62e-116: 371: 27.67		HS90A_HUMAN (4-705): 0: 1013: 60.67
+	Hs
		432386 M3K2_HUMAN (103-624): 4.98e-117: 369: 19.96		HS90A_HUMAN (4-705): 0: 1013: 60.67
+	Hs
		538446 AKT3_HUMAN (259-697): 1.64e-124: 384: 17.14		ENPL_HUMAN (3-680): 0: 893: 47.10
+	Hs
		538091 KPCA_HUMAN (174-679): 6.25e-122: 383: 16.41		ENPL_HUMAN (3-680): 0: 893: 47.10
+	Hs
		538122 AKT1_HUMAN (266-670): 9.7e-123: 379: 16.11		ENPL_HUMAN (3-680): 0: 893: 47.10