HitPredict

Interactor 1: IL2RB (P14784)
Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (Interleukin-15 receptor subunit beta) (p70-75) (p75) (CD antigen CD122)
Gene: IL2RB

Interactor 2: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	10602027, 8294403
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0043066 - negative regulation of apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 551 Hs			1 583
+	Mm
		557514 IL2RB_MOUSE (1-551): 3.91e-167: 486: 56.84		SHC1_MOUSE (1-583): 0: 527: 94.51
+	Hs
		500949 GHR_HUMAN (7-485): 4.72e-75: 252: 16.57		SHC1_HUMAN (1-583): 0: 531: 100.00
+	Hs
		666008 IL2RG_HUMAN (15-365): 1.05e-62: 212: 16.81		SHC1_HUMAN (1-583): 0: 531: 100.00
+	Hs
		581152 EPOR_HUMAN (7-446): 3.17e-60: 209: 18.49		SHC1_HUMAN (1-583): 0: 531: 100.00
+	Hs
		540464 IL2RB_HUMAN (1-551): 0: 527: 100.00		SHB_HUMAN (369-579): 2.01e-41: 158: 20.63
+	Hs
		540445 IL2RB_HUMAN (1-551): 0: 527: 100.00		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		540459 IL2RB_HUMAN (1-551): 0: 527: 100.00		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		548629 PRLR_HUMAN (24-547): 4.84e-75: 251: 12.96		VAV_HUMAN (163-578): 1.81e-54: 200: 12.25
+	Hs
		560471 PRLR_HUMAN (24-547): 4.84e-75: 251: 12.96		VAV2_HUMAN (189-579): 1.9e-42: 165: 12.97
+	Hs
		548635 EPOR_HUMAN (7-446): 3.17e-60: 209: 18.49		VAV_HUMAN (163-578): 1.81e-54: 200: 12.25
+	Hs
		500941 GHR_HUMAN (7-485): 4.72e-75: 252: 16.57		NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30
+	Hs
		500948 GHR_HUMAN (7-485): 4.72e-75: 252: 16.57		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		129180 GHR_HUMAN (7-485): 4.72e-75: 252: 16.57		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		682264 IL2RG_HUMAN (15-365): 1.05e-62: 212: 16.81		SHB_HUMAN (369-579): 2.01e-41: 158: 20.63
+	Hs
		581150 EPOR_HUMAN (7-446): 3.17e-60: 209: 18.49		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Mm
		540266 EPOR_MOUSE (7-427): 1.75e-58: 204: 19.30		P85A_MOUSE (300-581): 6.66e-38: 151: 15.99
+	Hs
		500956 GHR_HUMAN (7-485): 4.72e-75: 252: 16.57		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		682260 IL2RG_HUMAN (15-365): 1.05e-62: 212: 16.81		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		581157 EPOR_HUMAN (7-446): 3.17e-60: 209: 18.49		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		581163 EPOR_HUMAN (7-446): 3.17e-60: 209: 18.49		GRAP_HUMAN (482-578): 1.45e-13: 72.2: 25.71