HitPredict

Interactor 1: IL2RB (P14784)
Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (Interleukin-15 receptor subunit beta) (p70-75) (p75) (CD antigen CD122)
Gene: IL2RB

Interactor 2: SHB (Q15464)
SH2 domain-containing adapter protein B
Gene: SHB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.516

Property	Details
Experiments	12200137
Identification Methods	pull down
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 551 Hs			1 509
+	Hs
		540447 IL2RB_HUMAN (1-551): 0: 527: 100.00		SHC1_HUMAN (105-508): 5.28e-65: 222: 17.27
+	Mm
		557514 IL2RB_MOUSE (1-551): 3.91e-167: 486: 56.84		SHC1_MOUSE (105-508): 5.58e-66: 225: 17.12
+	Hs
		540459 IL2RB_HUMAN (1-551): 0: 527: 100.00		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Hs
		682264 IL2RG_HUMAN (15-365): 1.05e-62: 212: 16.81		SHB_HUMAN (1-509): 5.37e-127: 381: 100.00
+	Hs
		500949 GHR_HUMAN (7-485): 4.72e-75: 252: 16.57		SHC1_HUMAN (105-508): 5.28e-65: 222: 17.27
+	Hs
		500941 GHR_HUMAN (7-485): 4.72e-75: 252: 16.57		NCK1_HUMAN (157-504): 3.1e-55: 191: 14.25
+	Hs
		666008 IL2RG_HUMAN (15-365): 1.05e-62: 212: 16.81		SHC1_HUMAN (105-508): 5.28e-65: 222: 17.27
+	Hs
		145971 EPOR_HUMAN (7-446): 3.17e-60: 209: 18.49		SH2B2_HUMAN (56-507): 1.2e-64: 223: 13.94
+	Hs
		581152 EPOR_HUMAN (7-446): 3.17e-60: 209: 18.49		SHC1_HUMAN (105-508): 5.28e-65: 222: 17.27
+	Hs
		522759 EPOR_HUMAN (7-446): 3.17e-60: 209: 18.49		SRC_HUMAN (264-488): 5.65e-61: 211: 18.57
+	Hs
		500956 GHR_HUMAN (7-485): 4.72e-75: 252: 16.57		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Mm
		403425 EPHB2_MOUSE (28-329): 4.33e-52: 193: 14.47		SRC_MOUSE (264-488): 1.12e-63: 218: 18.64
+	Hs
		522803 EPHB2_HUMAN (28-329): 1.82e-52: 194: 14.15		SRC_HUMAN (264-488): 5.65e-61: 211: 18.57
+	Hs
		433265 EPHB2_HUMAN (28-329): 1.82e-52: 194: 14.15		YES_HUMAN (252-488): 8.79e-54: 191: 17.21
+	Hs
		682260 IL2RG_HUMAN (15-365): 1.05e-62: 212: 16.81		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Hs
		581157 EPOR_HUMAN (7-446): 3.17e-60: 209: 18.49		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Hs
		665574 EPHB2_HUMAN (28-329): 1.82e-52: 194: 14.15		GRB2_HUMAN (349-507): 2.61e-46: 162: 15.63
+	Hs
		665558 EPHB2_HUMAN (28-329): 1.82e-52: 194: 14.15		ABL2_HUMAN (354-487): 6.99e-36: 144: 26.12
+	Hs
		337360 EPHB2_HUMAN (28-329): 1.82e-52: 194: 14.15		ABL1_HUMAN (354-507): 1.09e-35: 143: 24.03
+	Hs
		581163 EPOR_HUMAN (7-446): 3.17e-60: 209: 18.49		GRAP_HUMAN (354-490): 1.31e-17: 83.5: 20.86