HitPredict

Interactor 1: TOP1 (P11387)
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I)
Gene: TOP1

Interactor 2: NONO (Q15233)
Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit)
Gene: NONO

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.80 0.60 0.696

The method score is based on:

Property Details
Experiments 24981860, 35271311, 15848144, 17481653
Identification Methods affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, pull down, anti bait coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0001650 - fibrillar center
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0003723 - RNA binding
GO:0005634 - nucleus
and 3 others

more...
Homologous interactions 7

Homologous interactions

Color coding for hit scores

1 765
Hs

1 471
+ Hs
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Service provided by Combinatics, Japan

Last updated: 11Aug2025