HitPredict

Interactor 1: PLAK (P14923)
Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3)
Gene: JUP

Interactor 2: ITF2 (P15884)
Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2)
Gene: TCF4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	14517306, 14661054
Identification Methods	pull down, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 745 Hs			1 667
+	Mm
		970136 CTNB1_MOUSE (1-731): 2.79e-173: 518: 67.38		ITF2_MOUSE (1-667): 0: 918: 96.87
+	Hs
		551080 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		ITF2_HUMAN (1-667): 0: 908: 100.00
+	Xl
		968536 Q63ZT4_XENLA (1-740): 7.86e-172: 514: 67.11		TFE2_XENLA (1-667): 0: 774: 50.51
+	Hs
		551195 ARMC8_HUMAN (135-530): 3.88e-16: 84.5: 19.12		ITF2_HUMAN (1-667): 0: 908: 100.00
+	Hs
		1216816 ARMC8_HUMAN (135-530): 3.88e-16: 84.5: 19.12		HTF4_HUMAN (3-667): 0: 783: 61.71