HitPredict

Interactor 1: PLAK (P14923)
Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3)
Gene: JUP

Interactor 2: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	33591636
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0140297 - DNA-binding transcription factor binding
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 745 Hs			1 482
+	Hs
		542396 PLAK_HUMAN (1-745): 0: 551: 100.00		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Hs
		717060 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		717252 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Hs
		717231 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		HDAC7_HUMAN (10-410): 1.09e-137: 421: 21.56
+	Hs
		134892 IMA3_HUMAN (228-670): 2.7e-65: 227: 16.01		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		134940 IMA3_HUMAN (228-670): 2.7e-65: 227: 16.01		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Hs
		131432 IMA4_HUMAN (228-670): 5.34e-64: 224: 15.79		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		131481 IMA4_HUMAN (228-670): 5.34e-64: 224: 15.79		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Hs
		853589 IMA5_HUMAN (231-685): 6.58e-61: 215: 15.06		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		853672 IMA5_HUMAN (231-685): 6.58e-61: 215: 15.06		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Hs
		542470 PLAK_HUMAN (1-745): 0: 551: 100.00		HDAC6_HUMAN (16-325): 2.05e-93: 309: 25.78
+	Hs
		853269 IMA1_HUMAN (270-664): 6.19e-48: 179: 14.32		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		853401 IMA1_HUMAN (270-664): 6.19e-48: 179: 14.32		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Hs
		238671 IMA7_HUMAN (262-685): 3.97e-45: 172: 13.86		HDAC1_HUMAN (1-482): 0: 668: 100.00
+	Hs
		238715 IMA7_HUMAN (262-685): 3.97e-45: 172: 13.86		HDAC2_HUMAN (1-478): 0: 666: 85.92
+	Hs
		717395 CTNB1_HUMAN (1-731): 1.58e-173: 519: 67.38		HDAC6_HUMAN (16-325): 2.05e-93: 309: 25.78
+	Hs
		239220 CTND1_HUMAN (203-728): 3.14e-90: 305: 16.25		HDAC6_HUMAN (16-325): 2.05e-93: 309: 25.78
+	Hs
		853744 IMA5_HUMAN (231-685): 6.58e-61: 215: 15.06		HDAC6_HUMAN (16-325): 2.05e-93: 309: 25.78