HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: NPR1 (P22211)
Nitrogen permease reactivator protein (EC 2.7.11.1) (Serine/threonine-protein kinase NPR1)
Gene: NPR1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	11805837, 37295430
Identification Methods	anti tag coimmunoprecipitation, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 705 Sc			1 790
+	Hs
		437908 HS90B_HUMAN (5-705): 0: 1022: 61.15		CDK2_HUMAN (435-748): 9.5e-138: 410: 23.98
+	Hs
		431549 HS90A_HUMAN (4-705): 0: 1013: 60.67		CDK2_HUMAN (435-748): 9.5e-138: 410: 23.98
+	Hs
		438075 HS90B_HUMAN (5-705): 0: 1022: 61.15		CDK3_HUMAN (435-750): 7.2e-133: 398: 24.14
+	Hs
		431741 HS90A_HUMAN (4-705): 0: 1013: 60.67		CDK3_HUMAN (435-750): 7.2e-133: 398: 24.14
+	Mm
		432419 HS90A_MOUSE (4-705): 0: 1012: 60.59		MK01_MOUSE (437-783): 3.73e-131: 396: 20.17
+	Hs
		437913 HS90B_HUMAN (5-705): 0: 1022: 61.15		MK03_HUMAN (408-783): 3.55e-127: 386: 20.21
+	Hs
		438208 HS90B_HUMAN (5-705): 0: 1022: 61.15		MK14_HUMAN (416-790): 3.17e-126: 383: 16.62
+	Hs
		431555 HS90A_HUMAN (4-705): 0: 1013: 60.67		MK03_HUMAN (408-783): 3.55e-127: 386: 20.21
+	Hs
		414683 HS90A_HUMAN (4-705): 0: 1013: 60.67		CDK1_HUMAN (435-746): 2.54e-127: 383: 24.68
+	Hs
		431896 HS90A_HUMAN (4-705): 0: 1013: 60.67		MK14_HUMAN (416-790): 3.17e-126: 383: 16.62
+	Mm
		432433 HS90A_MOUSE (4-705): 0: 1012: 60.59		MK03_MOUSE (437-783): 4.47e-126: 383: 20.74
+	Sc
		543393 HSC82_YEAST (1-705): 0: 977: 100.00		HOG1_YEAST (435-785): 5.2e-128: 391: 20.74
+	Sc
		543134 HSC82_YEAST (1-705): 0: 977: 100.00		FUS3_YEAST (436-780): 1.84e-128: 389: 20.56
+	Sc
		365984 HSP82_YEAST (1-705): 0: 968: 95.63		HOG1_YEAST (435-785): 5.2e-128: 391: 20.74
+	Sc
		544573 HSC82_YEAST (1-705): 0: 977: 100.00		RTK1_YEAST (408-774): 7.39e-77: 262: 41.56
+	Sc
		367027 HSP82_YEAST (1-705): 0: 968: 95.63		HRK1_YEAST (340-661): 2.13e-76: 264: 46.24
+	Hs
		154118 HS90B_HUMAN (5-705): 0: 1022: 61.15		CHK1_HUMAN (444-644): 7.38e-23: 104: 33.50
+	Hs
		154117 HS90A_HUMAN (4-705): 0: 1013: 60.67		CHK1_HUMAN (444-644): 7.38e-23: 104: 33.50
+	Sc
		543730 HSC82_YEAST (1-705): 0: 977: 100.00		HAL5_YEAST (432-656): 4.67e-27: 120: 31.72
+	Sc
		365561 HSP82_YEAST (1-705): 0: 968: 95.63		SNF1_YEAST (444-649): 4.14e-20: 97.4: 34.29