HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: SIS1 (P25294)
Protein SIS1
Gene: SIS1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.676

Property	Details
Experiments	31399574, 37295430, 33326013, 37845327
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0006457 - protein folding GO:0051082 - unfolded protein binding
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 705 Sc			1 352
+	Hs
		431571 HS90A_HUMAN (4-705): 0: 1013: 60.67		DNJA1_HUMAN (1-352): 2.53e-121: 357: 28.93
+	Hs
		243260 HS90A_HUMAN (4-705): 0: 1013: 60.67		DNJA2_HUMAN (2-352): 5.07e-121: 356: 28.09
+	Sc
		543273 HSC82_YEAST (1-705): 0: 977: 100.00		MAS5_YEAST (1-352): 1.41e-111: 332: 28.13
+	Sc
		365867 HSP82_YEAST (1-705): 0: 968: 95.63		MAS5_YEAST (1-352): 1.41e-111: 332: 28.13
+	Sc
		365844 HSP82_YEAST (1-705): 0: 968: 95.63		SIS1_YEAST (1-352): 6.96e-105: 313: 100.00
+	Dm
		1361622 Q9VAY2_DROME (3-676): 0: 833: 47.09		Q9VFV9_DROME (1-352): 8.97e-112: 332: 28.25