HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: MEK1 (P24719)
Meiosis-specific serine/threonine-protein kinase MEK1 (EC 2.7.11.1)
Gene: MEK1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.646

Property	Details
Experiments	11805837
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 705 Sc			1 497
+	Mm
		513660 HS90B_MOUSE (5-705): 0: 1025: 61.57		AKT1_MOUSE (36-497): 2.15e-120: 363: 19.25
+	Hs
		437928 HS90B_HUMAN (5-705): 0: 1022: 61.15		AKT2_HUMAN (36-487): 2.45e-120: 363: 18.82
+	Bt
		964601 HS90B_BOVIN (5-705): 0: 1022: 61.15		AKT1_BOVIN (36-497): 1.83e-120: 363: 19.67
+	Hs
		438633 HS90B_HUMAN (5-705): 0: 1022: 61.15		AKT3_HUMAN (36-487): 1.33e-119: 361: 19.96
+	Hs
		437927 HS90B_HUMAN (5-705): 0: 1022: 61.15		AKT1_HUMAN (36-497): 1.49e-119: 360: 19.25
+	Hs
		438148 HS90B_HUMAN (5-705): 0: 1022: 61.15		KCC2D_HUMAN (148-497): 7.94e-118: 357: 26.40
+	Rn
		812703 HS90A_RAT (4-705): 0: 1014: 60.59		AKT1_RAT (36-497): 2.45e-120: 363: 19.25
+	Hs
		431573 HS90A_HUMAN (4-705): 0: 1013: 60.67		AKT2_HUMAN (36-487): 2.45e-120: 363: 18.82
+	Hs
		431572 HS90A_HUMAN (4-705): 0: 1013: 60.67		AKT1_HUMAN (36-497): 1.49e-119: 360: 19.25
+	Hs
		438147 HS90B_HUMAN (5-705): 0: 1022: 61.15		KCC2G_HUMAN (148-496): 1.35e-114: 350: 26.76
+	Hs
		438631 HS90B_HUMAN (5-705): 0: 1022: 61.15		KCC2A_HUMAN (149-487): 4.1e-115: 349: 26.38
+	Hs
		431827 HS90A_HUMAN (4-705): 0: 1013: 60.67		KCC2D_HUMAN (148-497): 7.94e-118: 357: 26.40
+	Hs
		431826 HS90A_HUMAN (4-705): 0: 1013: 60.67		KCC2G_HUMAN (148-496): 1.35e-114: 350: 26.76
+	Hs
		438441 HS90B_HUMAN (5-705): 0: 1022: 61.15		KCC1G_HUMAN (163-485): 5.37e-109: 333: 29.05
+	Hs
		438210 HS90B_HUMAN (5-705): 0: 1022: 61.15		KCC4_HUMAN (141-486): 6.4e-104: 320: 29.60
+	Hs
		431898 HS90A_HUMAN (4-705): 0: 1013: 60.67		KCC4_HUMAN (141-486): 6.4e-104: 320: 29.60
+	Hs
		438350 HS90B_HUMAN (5-705): 0: 1022: 61.15		DCLK2_HUMAN (166-496): 9.3e-37: 146: 29.45
+	Hs
		437842 HS90B_HUMAN (5-705): 0: 1022: 61.15		KPSH1_HUMAN (167-444): 1.39e-36: 141: 32.04
+	Hs
		432057 HS90A_HUMAN (4-705): 0: 1013: 60.67		DCLK2_HUMAN (166-496): 9.3e-37: 146: 29.45
+	Hs
		431475 HS90A_HUMAN (4-705): 0: 1013: 60.67		KPSH1_HUMAN (167-444): 1.39e-36: 141: 32.04