HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: MSH2 (P25847)
DNA mismatch repair protein MSH2 (MutS protein homolog 2)
Gene: MSH2

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.759

Property	Details
Experiments	11805826, 16429126
Identification Methods	tandem affinity purification, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	HATPase_c_3~MutS_II, HATPase_c_3~MutS_III, HATPase_c_3~MutS_V
Common GO terms	GO:0005524 - ATP binding GO:0016887 - ATP hydrolysis activity
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 705 Sc			1 964
+	Sc
		544344 HSC82_YEAST (1-705): 0: 977: 100.00		MSH6_YEAST (17-884): 0: 628: 21.63
+	Sc
		366822 HSP82_YEAST (1-705): 0: 968: 95.63		MSH6_YEAST (17-884): 0: 628: 21.63
+	Sc
		365887 HSP82_YEAST (1-705): 0: 968: 95.63		MSH1_YEAST (30-876): 1.26e-171: 527: 20.74
+	Sc
		543255 HSC82_YEAST (1-705): 0: 977: 100.00		MSH3_YEAST (4-890): 1.12e-167: 518: 21.14
+	Sc
		366443 HSP82_YEAST (1-705): 0: 968: 95.63		MSH4_YEAST (136-943): 2.92e-163: 502: 19.52