HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: CHK1 (P38147)
Serine/threonine-protein kinase CHK1 (EC 2.7.11.1) (Checkpoint kinase 1)
Gene: CHK1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	28515311
Identification Methods	protein complementation assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HSP90~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 705 Sc			1 527
+	Hs
		438026 HS90B_HUMAN (5-705): 0: 1022: 61.15		AAPK2_HUMAN (4-510): 1.15e-126: 382: 22.16
+	Rn
		709234 HS90B_RAT (5-705): 0: 1025: 61.57		AAPK1_RAT (4-510): 2.72e-125: 379: 21.25
+	Bt
		964601 HS90B_BOVIN (5-705): 0: 1022: 61.15		AKT1_BOVIN (1-349): 1.12e-127: 382: 22.60
+	Hs
		154118 HS90B_HUMAN (5-705): 0: 1022: 61.15		CHK1_HUMAN (9-523): 4.81e-127: 381: 27.62
+	Hs
		438123 HS90B_HUMAN (5-705): 0: 1022: 61.15		AAPK1_HUMAN (4-510): 6.24e-125: 378: 21.25
+	Hs
		431689 HS90A_HUMAN (4-705): 0: 1013: 60.67		AAPK2_HUMAN (4-510): 1.15e-126: 382: 22.16
+	Hs
		154117 HS90A_HUMAN (4-705): 0: 1013: 60.67		CHK1_HUMAN (9-523): 4.81e-127: 381: 27.62
+	Mm
		513660 HS90B_MOUSE (5-705): 0: 1025: 61.57		AKT1_MOUSE (1-349): 1.47e-122: 369: 22.60
+	Rn
		871252 HS90A_RAT (4-705): 0: 1014: 60.59		AAPK1_RAT (4-510): 2.72e-125: 379: 21.25
+	Hs
		431800 HS90A_HUMAN (4-705): 0: 1013: 60.67		AAPK1_HUMAN (4-510): 6.24e-125: 378: 21.25
+	Hs
		437927 HS90B_HUMAN (5-705): 0: 1022: 61.15		AKT1_HUMAN (1-349): 4.34e-122: 368: 22.60
+	Rn
		812703 HS90A_RAT (4-705): 0: 1014: 60.59		AKT1_RAT (1-349): 3.77e-122: 368: 22.32
+	Hs
		431572 HS90A_HUMAN (4-705): 0: 1013: 60.67		AKT1_HUMAN (1-349): 4.34e-122: 368: 22.60
+	Mm
		432411 HS90A_MOUSE (4-705): 0: 1012: 60.59		AKT1_MOUSE (1-349): 1.47e-122: 369: 22.60
+	Rn
		871301 ENPL_RAT (3-700): 0: 897: 46.34		AAPK1_RAT (4-510): 2.72e-125: 379: 21.25
+	Hs
		538122 ENPL_HUMAN (3-680): 0: 893: 47.10		AKT1_HUMAN (1-349): 4.34e-122: 368: 22.60
+	Zm
		35496 A0A1D6LMW9_MAIZE (2-680): 0: 834: 47.53		A0A1D6QH07_MAIZE (3-527): 1.24e-136: 405: 22.08
+	Zm
		24080 A0A1D6LMW9_MAIZE (2-680): 0: 834: 47.53		A0A1D6ICZ3_MAIZE (15-469): 7.44e-133: 397: 20.91