Protein: MEF2D
Myocyte-specific enhancer factor 2D

Gene: MEF2D
Organism: Homo sapiens
Interactions: 76
UniProt ID: Q14814

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003700 - DNA-binding transcription factor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1034680

MEF2A
Myocyte-specific enhancer factor 2A

4

19

Small-scale

0.895

High

1034712

MEF2B
Myocyte-specific enhancer factor 2B

2

16

High-throughput

0.811

High

940965

HDAC4
Histone deacetylase 4

5

20

Small-scale

0.713

High

1132659

MK14
Mitogen-activated protein kinase 14

4

14

High-throughput

0.701

High

1132680

CABIN
Calcineurin-binding protein cabin-1

3

2

Small-scale

0.678

High

662227

PAX7
Paired box protein Pax-7

1

3

High-throughput

0.618

High

725255

TLX1
T-cell leukemia homeobox protein 1

1

1

High-throughput

0.618

High

877515

LHX1
LIM/homeobox protein Lhx1

1

3

High-throughput

0.618

High

895716

LHX2
LIM/homeobox protein Lhx2

1

3

High-throughput

0.618

High

1132668

LHX4
LIM/homeobox protein Lhx4

1

3

High-throughput

0.618

High

1132675

LHX3
LIM/homeobox protein Lhx3

1

3

High-throughput

0.618

High

1132670

TCAB1
Telomerase Cajal body protein 1

2

1

High-throughput

0.601

High

691011

1433T
14-3-3 protein theta

1

4

Small-scale

0.594

High

1097135

MK07
Mitogen-activated protein kinase 7

1

16

Small-scale

0.586

High

1067336

EP300
Histone acetyltransferase p300

2

4

Small-scale

0.584

High

1132677

HDAC5
Histone deacetylase 5

2

20

Small-scale

0.576

High

188278

HDAC3
Histone deacetylase 3

1

6

Small-scale

0.561

High

464962

SP1
Transcription factor Sp1

1

5

Small-scale

0.561

High

1101815

SKP2
S-phase kinase-associated protein 2

1

1

Small-scale

0.561

High

1106331

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

1

Small-scale

0.561

High

1025349

CDK6
Cyclin-dependent kinase 6

1

7

Small-scale

0.550

High

1132667

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.541

High

167511

TX1B3
Tax1-binding protein 3

1

1

High-throughput

0.536

High

429902

JUN
Transcription factor Jun

1

4

High-throughput

0.536

High

537174

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.536

High

162571

ANM5
Protein arginine N-methyltransferase 5

1

2

Small-scale

0.501

High

605686

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

1

Small-scale

0.501

High

728242

AKT1
RAC-alpha serine/threonine-protein kinase

1

2

Small-scale

0.501

High

1132661

CARM1
Histone-arginine methyltransferase CARM1

1

2

Small-scale

0.501

High

1132676

DNM3L
DNA

1

1

Small-scale

0.501

High

896690

ASCL1
Achaete-scute homolog 1

1

4

Small-scale

0.481

High

422112

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

791385

SYUA
Alpha-synuclein

1

0

Small-scale

0.480

High

1132679

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

161469

KMT2D
Histone-lysine N-methyltransferase 2D

1

2

Small-scale

0.479

High

172821

XPO1
Exportin-1

1

1

High-throughput

0.479

High

339749

KLF8
Krueppel-like factor 8

1

5

High-throughput

0.479

High

520048

ANDR
Androgen receptor

1

1

High-throughput

0.479

High

540866

ERG
Transcriptional regulator ERG

1

1

High-throughput

0.479

High

613040

EGR1
Early growth response protein 1

1

1

Small-scale

0.479

High

703141

TEAD1
Transcriptional enhancer factor TEF-1

1

2

High-throughput

0.479

High

775841

HNF1B
Hepatocyte nuclear factor 1-beta

1

4

High-throughput

0.479

High

776195

SOX6
Transcription factor SOX-6

1

5

High-throughput

0.479

High

872335

SOX2
Transcription factor SOX-2

1

4

High-throughput

0.479

High

886864

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.479

High

926662

HIRA
Protein HIRA

1

1

Small-scale

0.479

High

938447

PAX9
Paired box protein Pax-9

1

2

High-throughput

0.479

High

944654

KLF3
Krueppel-like factor 3

1

5

High-throughput

0.479

High

966320

1433G
14-3-3 protein gamma

1

4

High-throughput

0.479

High

967734

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

2

High-throughput

0.479

High

1056606

PAX8
Paired box protein Pax-8

1

2

High-throughput

0.479

High

1109727

HDAC1
Histone deacetylase 1

1

13

Small-scale

0.479

High

1118707

KLF5
Krueppel-like factor 5

1

6

High-throughput

0.479

High

1132662

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

1132664

SP7
Transcription factor Sp7

1

6

High-throughput

0.479

High

1132666

KAT2B
Histone acetyltransferase KAT2B

1

1

Small-scale

0.479

High

1132671

KLF16
Krueppel-like factor 16

1

4

High-throughput

0.479

High

129087

MEN1
Menin

1

0

Small-scale

0.458

High

714124

PML
Protein PML

1

0

High-throughput

0.458

High

986432

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

1054709

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.458

High

1132657

RBBP5
Retinoblastoma-binding protein 5

1

0

Small-scale

0.458

High

1132658

IRF4
Interferon regulatory factor 4

1

0

High-throughput

0.458

High

1132660

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1132663

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

1132665

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.458

High

1132669

THOC1
THO complex subunit 1

1

0

High-throughput

0.458

High

1132672

SENP3
Sentrin-specific protease 3

1

0

Small-scale

0.458

High

1132673

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1132674

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

0

Small-scale

0.458

High

1132678

ASF1A
Histone chaperone ASF1A

1

0

High-throughput

0.458

High

843564

HD
Huntingtin

1

0

High-throughput

0.438

High

1049297

1433F
14-3-3 protein eta

1

4

High-throughput

0.437

High

765522

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.426

High

347027

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

323377

TRI37
E3 ubiquitin-protein ligase TRIM37

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025