HitPredict

Interactor 1: HSC82 (P15108)
ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)
Gene: HSC82

Interactor 2: SGT1 (Q08446)
Protein SGT1 (Suppressor of G2 allele of SKP1)
Gene: SGT1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.750

Property	Details
Experiments	15340069, 16554755, 24466147, 31399574, 37295430, 34192536, 22461145, 15766533
Identification Methods	coimmunoprecipitation, affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 705 Sc			1 395
+	Hs
		438644 HS90B_HUMAN (5-705): 0: 1022: 61.15		SGT1_HUMAN (5-395): 1.67e-134: 391: 22.86
+	Hs
		432387 HS90A_HUMAN (4-705): 0: 1013: 60.67		SGT1_HUMAN (5-395): 1.67e-134: 391: 22.86
+	At
		646596 HS901_ARATH (3-705): 0: 993: 63.26		SGT1A_ARATH (5-395): 6.45e-115: 340: 24.12
+	Mm
		513706 HS90B_MOUSE (5-705): 0: 1025: 61.57		ITBP2_MOUSE (113-281): 6.04e-47: 165: 15.21
+	Hs
		438609 HS90B_HUMAN (5-705): 0: 1022: 61.15		ITBP2_HUMAN (113-281): 4.01e-47: 165: 15.21
+	Hs
		432350 HS90A_HUMAN (4-705): 0: 1013: 60.67		ITBP2_HUMAN (113-281): 4.01e-47: 165: 15.21
+	Mm
		432458 HS90A_MOUSE (4-705): 0: 1012: 60.59		ITBP2_MOUSE (113-281): 6.04e-47: 165: 15.21
+	Mm
		513702 HS90B_MOUSE (5-705): 0: 1025: 61.57		CHRD1_MOUSE (113-291): 5.2e-38: 141: 16.85
+	Hs
		438592 HS90B_HUMAN (5-705): 0: 1022: 61.15		CHRD1_HUMAN (113-289): 2.09e-36: 137: 16.48
+	Mm
		432455 HS90A_MOUSE (4-705): 0: 1012: 60.59		CHRD1_MOUSE (113-291): 5.2e-38: 141: 16.85
+	Hs
		111942 K9JA46_HUMAN (4-705): 0: 1013: 60.67		CHRD1_HUMAN (113-289): 2.09e-36: 137: 16.48
+	Hs
		432333 HS90A_HUMAN (4-705): 0: 1013: 60.67		CHRD1_HUMAN (113-289): 2.09e-36: 137: 16.48
+	Dm
		365474 HSP83_DROME (3-705): 0: 999: 59.58		CHRD1_DROME (114-292): 1.55e-38: 143: 13.44
+	Mm
		513680 HS90B_MOUSE (5-705): 0: 1025: 61.57		PPP5_MOUSE (5-185): 3.56e-18: 88.1: 18.68
+	Hs
		438021 HS90B_HUMAN (5-705): 0: 1022: 61.15		PPP5_HUMAN (5-185): 9.94e-18: 86.6: 19.23
+	Mm
		432427 HS90A_MOUSE (4-705): 0: 1012: 60.59		PPP5_MOUSE (5-185): 3.56e-18: 88.1: 18.68
+	Hs
		111935 K9JA46_HUMAN (4-705): 0: 1013: 60.67		PPP5_HUMAN (5-185): 9.94e-18: 86.6: 19.23
+	Hs
		431681 HS90A_HUMAN (4-705): 0: 1013: 60.67		PPP5_HUMAN (5-185): 9.94e-18: 86.6: 19.23
+	Hs
		213454 HS90B_HUMAN (5-705): 0: 1022: 61.15		SGTA_HUMAN (5-152): 1.02e-14: 76.2: 18.79
+	Hs
		213451 HS90A_HUMAN (4-705): 0: 1013: 60.67		SGTA_HUMAN (5-152): 1.02e-14: 76.2: 18.79