HitPredict

Interactor 1: INSR (P15127)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Interactor 2: PDIA6 (Q63081)
Protein disulfide-isomerase A6 (EC 5.3.4.1) (Calcium-binding protein 1) (CaBP1) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7)
Gene: PDIA6

Species: Rattus norvegicus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	30300385
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1383 Rn			1 440
+	Hs
		411391 INSR_HUMAN (27-1383): 0: 1527: 95.43		PDIA6_HUMAN (1-440): 2.29e-133: 392: 94.77
+	Hs
		411442 INSR_HUMAN (27-1383): 0: 1527: 95.43		TXND5_HUMAN (181-433): 1.9e-41: 154: 19.40
+	Rn
		102493 INSR_RAT (1-1383): 0: 1575: 100.00		G3V6T7_RAT (67-273): 5.8e-17: 85.4: 21.13
+	Rn
		388065 INSR_RAT (1-1383): 0: 1575: 100.00		PDIA1_RAT (29-420): 3.01e-12: 70.3: 12.17
+	Rn
		514117 INSR_RAT (1-1383): 0: 1575: 100.00		PDIA3_RAT (22-386): 9.99e-11: 65.7: 12.34
+	Hs
		411285 INSR_HUMAN (27-1383): 0: 1527: 95.43		PDIA4_HUMAN (67-271): 2.65e-18: 89.2: 21.80
+	Hs
		411430 INSR_HUMAN (27-1383): 0: 1527: 95.43		DJC10_HUMAN (15-412): 3.97e-15: 79.6: 13.05
+	Hs
		411271 INSR_HUMAN (27-1383): 0: 1527: 95.43		PDIA1_HUMAN (62-387): 6.7e-10: 63: 13.33
+	Hs
		537760 INSRR_HUMAN (12-1339): 0: 1276: 51.80		TXND5_HUMAN (181-433): 1.9e-41: 154: 19.40
+	Hs
		435520 IGF1R_HUMAN (13-1381): 0: 1302: 55.77		PDIA4_HUMAN (67-271): 2.65e-18: 89.2: 21.80
+	Hs
		435692 IGF1R_HUMAN (13-1381): 0: 1302: 55.77		DJC10_HUMAN (15-412): 3.97e-15: 79.6: 13.05
+	Hs
		423108 IGF1R_HUMAN (13-1381): 0: 1302: 55.77		PDIA1_HUMAN (62-387): 6.7e-10: 63: 13.33
+	Hs
		537757 INSRR_HUMAN (12-1339): 0: 1276: 51.80		DJC10_HUMAN (15-412): 3.97e-15: 79.6: 13.05
+	Hs
		1072583 EPHA7_HUMAN (664-1321): 0: 568: 22.55		ERP44_HUMAN (4-440): 1.62e-62: 209: 17.33
+	Hs
		531732 EPHB2_HUMAN (662-1317): 0: 577: 23.01		PDIA4_HUMAN (67-271): 2.65e-18: 89.2: 21.80
+	Hs
		531731 EPHA8_HUMAN (663-1323): 1.14e-174: 548: 22.59		PDIA4_HUMAN (67-271): 2.65e-18: 89.2: 21.80
+	Hs
		445818 ROS1_HUMAN (1020-1292): 1.06e-71: 267: 49.46		PDIA4_HUMAN (67-271): 2.65e-18: 89.2: 21.80
+	Hs
		532019 ALK_HUMAN (997-1340): 6.12e-71: 264: 41.57		PDIA4_HUMAN (67-271): 2.65e-18: 89.2: 21.80
+	Hs
		445858 ROS1_HUMAN (1020-1292): 1.06e-71: 267: 49.46		DJC10_HUMAN (15-412): 3.97e-15: 79.6: 13.05
+	Hs
		531733 LTK_HUMAN (1014-1292): 4.56e-70: 255: 43.82		PDIA4_HUMAN (67-271): 2.65e-18: 89.2: 21.80