HitPredict

Interactor 1: RAC2 (P15153)
Ras-related C3 botulinum toxin substrate 2 (GX) (Small G protein) (p21-Rac2)
Gene: RAC2

Interactor 2: WASP (P42768)
Actin nucleation-promoting factor WAS (Wiskott-Aldrich syndrome protein) (WASp)
Gene: WAS

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	14521508
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PBD~Ras
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0019901 - protein kinase binding GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 502
+	Hs
		126910 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		WASL_HUMAN (15-311): 1.14e-115: 352: 47.67
+	Hs
		126927 CDC42_HUMAN (1-192): 4.69e-77: 230: 68.75		WASL_HUMAN (15-311): 1.14e-115: 352: 47.67
+	Hs
		790658 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		WASP_HUMAN (1-487): 8.09e-99: 308: 100.00
+	Hs
		564443 RHOQ_HUMAN (4-190): 1.9e-82: 244: 62.03		WASP_HUMAN (1-487): 8.09e-99: 308: 100.00
+	Hs
		790652 RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01		WASP_HUMAN (1-487): 8.09e-99: 308: 100.00
+	Hs
		790653 CDC42_HUMAN (1-192): 4.69e-77: 230: 68.75		WASP_HUMAN (1-487): 8.09e-99: 308: 100.00
+	Dm
		776909 RAC1_DROME (1-192): 7.95e-82: 242: 89.06		Q9VAT0_DROME (13-324): 3.69e-84: 271: 35.98
+	Dm
		776938 CDC42_DROME (1-192): 1.03e-76: 229: 69.27		Q9VAT0_DROME (13-324): 3.69e-84: 271: 35.98
+	Ce
		975571 RAC1_CAEEL (1-192): 6e-83: 245: 79.69		Q17795_CAEEL (13-498): 3.91e-60: 209: 21.66
+	Ce
		104465 G5EBV3_CAEEL (2-192): 1.3e-77: 231: 62.30		Q17795_CAEEL (13-498): 3.91e-60: 209: 21.66
+	Ce
		983032 CDC42_CAEEL (1-192): 1.77e-75: 226: 67.71		Q17795_CAEEL (13-498): 3.91e-60: 209: 21.66
+	Hs
		840659 RHOA_HUMAN (5-192): 9.29e-76: 227: 54.26		DYN2_HUMAN (244-438): 9.39e-25: 110: 17.54
+	Sc
		580329 CDC42_YEAST (1-192): 5.43e-76: 227: 67.19		STE20_YEAST (152-471): 7.83e-21: 98.2: 14.84
+	Hs
		297823 RAC1_HUMAN (1-192): 1.69e-84: 249: 92.19		K0754_HUMAN (242-499): 2.4e-10: 65.5: 13.11
+	Hs
		297812 RAC2_HUMAN (1-192): 3.42e-82: 243: 100.00		K0754_HUMAN (242-499): 2.4e-10: 65.5: 13.11
+	Hs
		297819 RAC3_HUMAN (1-191): 1.72e-78: 234: 89.01		K0754_HUMAN (242-499): 2.4e-10: 65.5: 13.11
+	Hs
		195972 RHOA_HUMAN (5-192): 9.29e-76: 227: 54.26		PLXB1_HUMAN (307-500): 2.97e-12: 71.5: 23.50
+	Hs
		297827 RHOG_HUMAN (1-192): 1.64e-77: 231: 70.83		K0754_HUMAN (242-499): 2.4e-10: 65.5: 13.11
+	Hs
		297820 RHOA_HUMAN (5-192): 9.29e-76: 227: 54.26		K0754_HUMAN (242-499): 2.4e-10: 65.5: 13.11
+	Hs
		297809 RHOC_HUMAN (5-192): 1.83e-73: 221: 54.79		K0754_HUMAN (242-499): 2.4e-10: 65.5: 13.11