HitPredict

Interactor 1: ARSA (P15289)
Arylsulfatase A (ASA) (EC 3.1.6.8) (Cerebroside-sulfatase) [Cleaved into: Arylsulfatase A component B; Arylsulfatase A component C]
Gene: ARSA

Interactor 2: GALNS (P34059)
N-acetylgalactosamine-6-sulfatase (EC 3.1.6.4) (Chondroitinsulfatase) (Chondroitinase) (Galactose-6-sulfate sulfatase) (GalN6S) (N-acetylgalactosamine-6-sulfate sulfatase) (GalNAc6S sulfatase)
Gene: GALNS

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Sulfatase~Sulfatase, Sulfatase~Sulfatase_C, Sulfatase_C~Sulfatase_C
Common GO terms	GO:0004065 - arylsulfatase activity GO:0005576 - extracellular region GO:0008484 - sulfuric ester hydrolase activity GO:0035578 - azurophil granule lumen GO:0043202 - lysosomal lumen and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 507 Hs			1 522
+	Hs
		849852 ARSL_HUMAN (1-506): 0: 522: 29.67		ARSD_HUMAN (20-514): 4.5e-179: 518: 29.35
+	Hs
		546589 ARSA_HUMAN (1-507): 0: 579: 100.00		ARSA_HUMAN (29-512): 1.07e-150: 442: 35.17
+	Hs
		546599 ARSA_HUMAN (1-507): 0: 579: 100.00		SPHM_HUMAN (26-504): 1.57e-99: 311: 21.69
+	Hs
		606863 GALNS_HUMAN (6-505): 1.26e-155: 454: 34.87		IDS_HUMAN (7-459): 3.2e-98: 309: 18.96
+	Hs
		549097 GNS_HUMAN (15-449): 5.05e-122: 370: 20.46		SULF2_HUMAN (30-381): 2.21e-92: 302: 20.56
+	Hs
		1219500 SULF1_HUMAN (20-426): 1.59e-114: 360: 20.64		SULF2_HUMAN (30-381): 2.21e-92: 302: 20.56
+	Hs
		606866 SPHM_HUMAN (2-491): 6.19e-100: 311: 22.87		IDS_HUMAN (7-459): 3.2e-98: 309: 18.96