Protein: LRC8E
Volume-regulated anion channel subunit LRRC8E (Leucine-rich repeat-containing protein 8E)

Gene: LRC8E, LRRC8E
Organism: Homo sapiens
Interactions: 100
UniProt ID: Q6NSJ5

Gene Ontology (top 5):
GO:0005225 - volume-sensitive anion channel activity
GO:0005737 - cytoplasm
GO:0005765 - lysosomal membrane
GO:0005789 - endoplasmic reticulum membrane
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1237937

LRC8B
Volume-regulated anion channel subunit LRRC8B

3

19

High-throughput

0.855

High

1237963

TRIM2
Tripartite motif-containing protein 2

4

4

High-throughput

0.697

High

379002

PIGR
Polymeric immunoglobulin receptor

1

1

High-throughput

0.691

High

520885

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

2

High-throughput

0.691

High

575665

GPIX
Platelet glycoprotein IX

1

8

High-throughput

0.691

High

1237939

LRC55
Leucine-rich repeat-containing protein 55

1

20

High-throughput

0.691

High

1237941

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.691

High

1237968

RXFP1
Relaxin receptor 1

1

19

High-throughput

0.691

High

1237972

CLC2D
C-type lectin domain family 2 member D

1

1

High-throughput

0.691

High

127354

LEG8
Galectin-8

3

6

High-throughput

0.667

High

1237943

LRC8A
Volume-regulated anion channel subunit LRRC8A

1

18

Small-scale

0.665

High

268923

FCG3B
Low affinity immunoglobulin gamma Fc region receptor III-B

3

3

High-throughput

0.656

High

1237945

LNX2
Ligand of Numb protein X 2

3

13

High-throughput

0.653

High

318205

DDHD2
Triacylglycerol hydrolase DDHD2

2

1

High-throughput

0.628

High

547459

DMD
Dystrophin

2

6

High-throughput

0.628

High

845515

PI2R
Prostacyclin receptor

2

7

High-throughput

0.628

High

855333

5HT3A
5-hydroxytryptamine receptor 3A

2

9

High-throughput

0.628

High

938574

PSA
Puromycin-sensitive aminopeptidase

2

4

High-throughput

0.628

High

1237964

NMUR2
Neuromedin-U receptor 2

2

3

High-throughput

0.628

High

279051

TRIM3
Tripartite motif-containing protein 3

2

4

High-throughput

0.606

High

1010449

GPSM2
G-protein-signaling modulator 2

2

2

High-throughput

0.606

High

635332

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

2

0

High-throughput

0.602

High

851140

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

2

2

High-throughput

0.601

High

963192

LYSC
Lysozyme C

1

0

High-throughput

0.578

High

1168736

DOXA2
Dual oxidase maturation factor 2

2

0

High-throughput

0.576

High

379659

IGHA1
Immunoglobulin heavy constant alpha 1

1

1

High-throughput

0.575

High

379745

IGHA2
Immunoglobulin heavy constant alpha 2

1

1

High-throughput

0.575

High

541031

PIM1
Serine/threonine-protein kinase pim-1

1

1

High-throughput

0.575

High

247127

TBCD4
TBC1 domain family member 4

2

1

High-throughput

0.574

High

1237938

DLK2
Protein delta homolog 2

2

4

High-throughput

0.574

High

182590

GP182
G-protein coupled receptor 182

1

7

High-throughput

0.536

High

248475

O10H2
Olfactory receptor 10H2

1

5

High-throughput

0.536

High

349445

TSN15
Tetraspanin-15

1

3

High-throughput

0.536

High

370082

CYTS
Cystatin-S

1

1

High-throughput

0.536

High

370207

CYTN
Cystatin-SN

1

1

High-throughput

0.536

High

537351

HSP7C
Heat shock cognate 71 kDa protein

1

7

High-throughput

0.536

High

564916

ICAM2
Intercellular adhesion molecule 2

1

2

High-throughput

0.536

High

595061

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

10

High-throughput

0.536

High

600831

HSP76
Heat shock 70 kDa protein 6

1

7

High-throughput

0.536

High

669009

FPR2
N-formyl peptide receptor 2

1

11

High-throughput

0.536

High

698767

CALX
Calnexin

1

4

High-throughput

0.536

High

722854

SSR1
Somatostatin receptor type 1

1

7

High-throughput

0.536

High

930939

HSP72
Heat shock-related 70 kDa protein 2

1

7

High-throughput

0.536

High

1008040

KCJ10
ATP-sensitive inward rectifier potassium channel 10

1

4

High-throughput

0.536

High

1195435

NKAI1
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

1

2

High-throughput

0.536

High

1237948

SIDT2
SID1 transmembrane family member 2

1

3

High-throughput

0.536

High

1237949

OR4N2
Olfactory receptor 4N2

1

2

High-throughput

0.536

High

1237953

LPAR1
Lysophosphatidic acid receptor 1

1

5

High-throughput

0.536

High

1237962

TM2D3
TM2 domain-containing protein 3

1

1

High-throughput

0.536

High

1237966

S22A4
Solute carrier family 22 member 4

1

2

High-throughput

0.536

High

1237967

TTYH1
Protein tweety homolog 1

1

4

High-throughput

0.536

High

1237970

HCST
Hematopoietic cell signal transducer

1

3

High-throughput

0.536

High

1237978

O10H1
Olfactory receptor 10H1

1

5

High-throughput

0.536

High

1237950

OR4D6
Olfactory receptor 4D6

1

2

High-throughput

0.515

High

139238

UPK2
Uroplakin-2

1

0

High-throughput

0.513

High

391035

TRFL
Lactotransferrin

1

0

High-throughput

0.513

High

547324

CP19A
Aromatase

1

0

High-throughput

0.513

High

1126305

PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H

1

0

High-throughput

0.513

High

1203686

TTMP
TPA-induced transmembrane protein

1

0

High-throughput

0.513

High

1237940

TMC6
Transmembrane channel-like protein 6

1

0

High-throughput

0.513

High

1237955

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

1237956

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.513

High

1237959

SGCZ
Zeta-sarcoglycan

1

0

High-throughput

0.513

High

1237960

P2RX4
P2X purinoceptor 4

1

0

High-throughput

0.513

High

1237969

KCMB3
Calcium-activated potassium channel subunit beta-3

1

0

High-throughput

0.513

High

1237971

SHPK
Sedoheptulokinase

1

0

High-throughput

0.513

High

1237974

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.513

High

610716

TCPA
T-complex protein 1 subunit alpha

1

2

High-throughput

0.489

High

723929

LCN1
Lipocalin-1

1

1

High-throughput

0.489

High

786136

LONM
Lon protease homolog, mitochondrial

1

3

High-throughput

0.489

High

1237957

TM169
Transmembrane protein 169

1

1

High-throughput

0.489

High

1237976

SGT1
Protein SGT1 homolog

1

17

High-throughput

0.489

High

1237977

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

1237944

RHG24
Rho GTPase-activating protein 24

1

3

High-throughput

0.479

High

1237942

NUTM1
NUT family member 1

1

0

High-throughput

0.460

High

1004707

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

97129

E9PNY5
Fc gamma receptor IIIb

1

3

High-throughput

0.445

High

170811

CLGN
Calmegin

1

4

High-throughput

0.445

High

516197

HS71B
Heat shock 70 kDa protein 1B

1

7

High-throughput

0.445

High

539711

ACHB
Acetylcholine receptor subunit beta

1

4

High-throughput

0.445

High

1237952

CTL1
Choline transporter-like protein 1

1

3

High-throughput

0.445

High

1237975

S22AE
Solute carrier family 22 member 14

1

2

High-throughput

0.445

High

76542

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

11

High-throughput

0.437

High

1155463

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.437

High

222288

PSCA
Prostate stem cell antigen

1

0

High-throughput

0.426

High

1237954

ESR2
Estrogen receptor beta

1

9

High-throughput

0.407

High

1237973

TRM6
tRNA

2

0

High-throughput

0.328

High

1208541

SMAG2
Protein Smaug homolog 2

2

0

High-throughput

0.316

High

251154

B4GT4
Beta-1,4-galactosyltransferase 4

1

0

High-throughput

0.279

Low

286553

SG2A1
Mammaglobin-B

1

0

High-throughput

0.279

Low

296712

TUSC2
Tumor suppressor candidate 2

1

0

High-throughput

0.279

Low

1157290

PROL4
Proline-rich protein 4

1

0

High-throughput

0.279

Low

1237946

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.279

Low

1237947

AR6P6
ADP-ribosylation factor-like protein 6-interacting protein 6

1

0

High-throughput

0.279

Low

1237951

BPIB1
BPI fold-containing family B member 1

1

0

High-throughput

0.279

Low

1237961

PROL1
Opiorphin prepropeptide

1

0

High-throughput

0.279

Low

1237965

LACRT
Extracellular glycoprotein lacritin

1

0

High-throughput

0.279

Low

1237958

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

0

High-throughput

0.269

Low

1237979

PPME1
Protein phosphatase methylesterase 1

1

0

Small-scale

0.249

Low

1237936

NPAL3
NIPA-like protein 3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025