HitPredict

Interactor 1: EZRI (P15311)
Ezrin (Cytovillin) (Villin-2) (p81)
Gene: EZR

Interactor 2: NOTC2 (Q04721)
Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)]
Gene: NOTCH2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	29568061, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 586 Hs			1 2471
+	Hs
		980545 E41LA_HUMAN (1-576): 5.03e-116: 361: 16.47		NOTC2_HUMAN (22-2471): 0: 1386: 100.00
+	Hs
		547029 EZRI_HUMAN (1-586): 5.67e-178: 517: 100.00		ANK3_HUMAN (1672-2286): 2.46e-106: 385: 14.71
+	Hs
		547010 EZRI_HUMAN (1-586): 5.67e-178: 517: 100.00		ANK2_HUMAN (1770-2394): 3.7e-103: 374: 17.01
+	Hs
		1021479 FARP1_HUMAN (3-549): 1.97e-117: 375: 19.07		ANK3_HUMAN (1672-2286): 2.46e-106: 385: 14.71
+	Hs
		965179 FARP1_HUMAN (3-549): 1.97e-117: 375: 19.07		ANK2_HUMAN (1770-2394): 3.7e-103: 374: 17.01
+	Hs
		1021466 E41LA_HUMAN (1-576): 5.03e-116: 361: 16.47		ANK3_HUMAN (1672-2286): 2.46e-106: 385: 14.71
+	Hs
		965178 E41L3_HUMAN (2-466): 2.17e-114: 367: 22.83		ANK2_HUMAN (1770-2394): 3.7e-103: 374: 17.01
+	Hs
		257705 E41L5_HUMAN (5-586): 7.7e-142: 430: 21.28		ANR17_HUMAN (1801-2469): 1.06e-69: 264: 17.34
+	Hs
		1219853 E41L5_HUMAN (5-586): 7.7e-142: 430: 21.28		ANKH1_HUMAN (1868-2428): 1.04e-68: 261: 13.64
+	Hs
		640088 MOES_HUMAN (1-586): 4.45e-161: 474: 72.70		CRUM1_HUMAN (1338-1550): 1.59e-15: 85.7: 22.22
+	Hs
		640287 PTN3_HUMAN (18-295): 2.55e-32: 134: 31.82		ANR50_HUMAN (1638-2464): 2.4e-115: 405: 13.86
+	Hs
		946793 E41L5_HUMAN (5-586): 7.7e-142: 430: 21.28		CRUM1_HUMAN (1338-1550): 1.59e-15: 85.7: 22.22
+	Dm
		484984 MOEH_DROME (2-586): 8.49e-145: 432: 56.01		CRB_DROME (1355-1644): 1.27e-09: 66.1: 13.53
+	Dm
		422941 Q9W0R3_DROME (3-516): 4.6e-124: 390: 21.76		NOTCH_DROME (2-344): 3.6e-21: 104: 21.89
+	Hs
		1126606 E41L5_HUMAN (5-586): 7.7e-142: 430: 21.28		CRUM2_HUMAN (1268-1413): 8.02e-09: 63.5: 32.70
+	Hs
		946792 E41LB_HUMAN (4-554): 6.81e-121: 380: 17.59		CRUM1_HUMAN (1338-1550): 1.59e-15: 85.7: 22.22
+	Dm
		49536 A0T1Z5_DROME (3-357): 8.46e-124: 384: 25.21		CRB_DROME (1355-1644): 1.27e-09: 66.1: 13.53