Protein: GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (EC 3.6.5.-) (Adenylate cyclase-stimulating G alpha protein)

Gene: GNAS2, GNAS
Organism: Homo sapiens
Interactions: 221
UniProt ID: P63092

Gene Ontology (top 5):
GO:0002862 - negative regulation of inflammatory response to antigenic stimulus
GO:0003091 - renal water homeostasis
GO:0003924 - GTPase activity
GO:0003925 - G protein activity
GO:0005525 - GTP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

845506

PI2R
Prostacyclin receptor

4

20

Small-scale

0.878

High

458370

ADRB2
Beta-2 adrenergic receptor

4

9

Small-scale

0.878

High

989806

RIC8B
Chaperone Ric-8B

3

13

Small-scale

0.865

High

799625

GNAL
Guanine nucleotide-binding protein G(olf) subunit alpha

3

12

High-throughput

0.861

High

989723

GNA12
Guanine nucleotide-binding protein subunit alpha-12

3

13

High-throughput

0.847

High

989710

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

2

12

Small-scale

0.768

High

181082

AXIN1
Axin-1

1

20

Small-scale

0.724

High

983443

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

5

20

Small-scale

0.716

High

989820

MAGD2
Melanoma-associated antigen D2

5

2

Small-scale

0.714

High

630149

ACM3
Muscarinic acetylcholine receptor M3

1

10

High-throughput

0.698

High

989803

CLTR2
Cysteinyl leukotriene receptor 2

1

18

High-throughput

0.698

High

989805

RL3R1
Relaxin-3 receptor 1

1

18

High-throughput

0.698

High

984059

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

3

20

High-throughput

0.667

High

536928

HSP7C
Heat shock cognate 71 kDa protein

4

4

High-throughput

0.666

High

880901

MTR1B
Melatonin receptor type 1B

1

18

High-throughput

0.656

High

893552

GBG4

3

20

High-throughput

0.656

High

989713

GBG5

3

20

High-throughput

0.656

High

989728

TROP
Trophinin

3

2

High-throughput

0.656

High

989795

GBB4
Guanine nucleotide-binding protein subunit beta-4

3

20

High-throughput

0.656

High

989808

OCAD1
OCIA domain-containing protein 1

3

1

High-throughput

0.656

High

640504

TA2R
Thromboxane A2 receptor

1

20

Small-scale

0.647

High

641904

DRD5
D(1B) dopamine receptor

1

10

Small-scale

0.647

High

719775

V2R
Vasopressin V2 receptor

1

15

Small-scale

0.647

High

833403

RGS2
Regulator of G-protein signaling 2

1

20

Small-scale

0.647

High

662775

CPT2
Carnitine O-palmitoyltransferase 2, mitochondrial

3

0

High-throughput

0.638

High

563586

CFTR
Cystic fibrosis transmembrane conductance regulator

3

5

High-throughput

0.636

High

896999

MAP2
Methionine aminopeptidase 2

3

0

High-throughput

0.628

High

989724

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

3

0

High-throughput

0.628

High

363106

EGFR
Epidermal growth factor receptor

2

8

Small-scale

0.624

High

270444

FZD7
Frizzled-7

1

2

High-throughput

0.621

High

846058

GLP1R
Glucagon-like peptide 1 receptor

1

9

Small-scale

0.621

High

723659

CALCR
Calcitonin receptor

1

9

Small-scale

0.618

High

732970

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

9

Small-scale

0.618

High

762197

CRFR1
Corticotropin-releasing factor receptor 1

1

9

Small-scale

0.618

High

845591

MUC18
Cell surface glycoprotein MUC18

1

2

High-throughput

0.618

High

989719

ANK2
Ankyrin-2

1

4

High-throughput

0.618

High

989793

PKHG2
Pleckstrin homology domain-containing family G member 2

1

9

Small-scale

0.618

High

989794

ECT2
Protein ECT2

1

10

High-throughput

0.618

High

911910

JAK3
Tyrosine-protein kinase JAK3

2

8

High-throughput

0.611

High

989780

DNJC7
DnaJ homolog subfamily C member 7

2

2

High-throughput

0.611

High

989814

ARMX3
Armadillo repeat-containing X-linked protein 3

2

1

High-throughput

0.611

High

241342

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

400620

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

9

High-throughput

0.584

High

466197

RHOC
Rho-related GTP-binding protein RhoC

2

17

Small-scale

0.584

High

893566

GBG10

2

20

High-throughput

0.584

High

948053

GBG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

2

20

Small-scale

0.584

High

989800

ANLN
Anillin

2

8

High-throughput

0.584

High

989823

SNX13
Sorting nexin-13

1

20

Small-scale

0.579

High

342822

HERC2
E3 ubiquitin-protein ligase HERC2

2

3

High-throughput

0.571

High

948768

CD81
CD81 antigen

2

7

Small-scale

0.571

High

989775

SYGP1
Ras/Rap GTPase-activating protein SynGAP

2

16

High-throughput

0.571

High

989766

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

2

0

Small-scale

0.559

High

354941

CHK2
Serine/threonine-protein kinase Chk2

1

5

High-throughput

0.541

High

529570

TAU
Microtubule-associated protein tau

1

16

High-throughput

0.536

High

772726

MYH9
Myosin-9

1

3

High-throughput

0.536

High

989739

DREB
Drebrin

1

1

High-throughput

0.536

High

989757

SYNPO
Synaptopodin

1

2

High-throughput

0.536

High

155102

SOCS2
Suppressor of cytokine signaling 2

1

2

High-throughput

0.515

High

156025

SOCS6
Suppressor of cytokine signaling 6

1

2

High-throughput

0.515

High

989740

FSCN1
Fascin

1

1

High-throughput

0.515

High

989779

TTC1
Tetratricopeptide repeat protein 1

1

6

Small-scale

0.515

High

409344

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

0

Small-scale

0.513

High

936707

NP1L1
Nucleosome assembly protein 1-like 1

1

0

High-throughput

0.513

High

989777

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

989770

OPTN
Optineurin

1

11

High-throughput

0.501

High

593331

PGFRA
Platelet-derived growth factor receptor alpha

1

5

High-throughput

0.500

High

646815

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.493

High

760887

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

0

High-throughput

0.493

High

989821

RUVB1
RuvB-like 1

1

0

High-throughput

0.493

High

989715

NUCB2
Nucleobindin-2

1

7

High-throughput

0.481

High

989722

NUCB1
Nucleobindin-1

1

7

High-throughput

0.481

High

989776

PANX1
Pannexin-1

1

0

Small-scale

0.480

High

125396

LEG9
Galectin-9

1

2

High-throughput

0.479

High

131928

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

2

High-throughput

0.479

High

157215

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.479

High

164310

NRP1
Neuropilin-1

1

5

High-throughput

0.479

High

178241

NPC1
NPC intracellular cholesterol transporter 1

1

2

High-throughput

0.479

High

179869

BET1
BET1 homolog

1

1

High-throughput

0.479

High

222923

PRC1
Protein regulator of cytokinesis 1

1

3

High-throughput

0.479

High

227489

SPOP
Speckle-type POZ protein

1

1

High-throughput

0.479

High

247809

NUPR1
Nuclear protein 1

1

3

High-throughput

0.479

High

318715

RHBT1
Rho-related BTB domain-containing protein 1

1

19

High-throughput

0.479

High

323303

TRI37
E3 ubiquitin-protein ligase TRIM37

1

7

High-throughput

0.479

High

328659

VAMP5
Vesicle-associated membrane protein 5

1

3

High-throughput

0.479

High

330853

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

373870

RASN
GTPase NRas

1

11

High-throughput

0.479

High

375380

RASK
GTPase KRas

1

11

High-throughput

0.479

High

399961

CATA
Catalase

1

1

High-throughput

0.479

High

411712

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.479

High

459265

CATL1
Procathepsin L

1

1

High-throughput

0.479

High

519922

ANDR
Androgen receptor

1

9

High-throughput

0.479

High

521295

ARAF
Serine/threonine-protein kinase A-Raf

1

9

High-throughput

0.479

High

534913

BIP
Endoplasmic reticulum chaperone BiP

1

8

High-throughput

0.479

High

560358

IFM1
Interferon-induced transmembrane protein 1

1

5

High-throughput

0.479

High

578446

BRAF
Serine/threonine-protein kinase B-raf

1

12

High-throughput

0.479

High

601231

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

637441

FLNA
Filamin-A

1

2

High-throughput

0.479

High

651264

CBL
E3 ubiquitin-protein ligase CBL

1

4

High-throughput

0.479

High

692918

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.479

High

693286

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

2

High-throughput

0.479

High

772377

PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

1

1

Small-scale

0.479

High

774275

BASI
Basigin

1

3

High-throughput

0.479

High

830524

CCNF
Cyclin-F

1

4

High-throughput

0.479

High

862011

YAP1
Transcriptional coactivator YAP1

1

10

High-throughput

0.479

High

907367

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

5

High-throughput

0.479

High

910004

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

953383

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

955039

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

961935

RHOA
Transforming protein RhoA

1

17

High-throughput

0.479

High

966180

1433G
14-3-3 protein gamma

1

1

High-throughput

0.479

High

970283

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

977919

RHOB
Rho-related GTP-binding protein RhoB

1

19

High-throughput

0.479

High

988257

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

989711

GBG1
Guanine nucleotide-binding protein G(T) subunit gamma-T1

1

20

High-throughput

0.479

High

989712

GBG3

1

20

High-throughput

0.479

High

989714

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

989716

RHOG
Rho-related GTP-binding protein RhoG

1

16

High-throughput

0.479

High

989717

VIGLN
Vigilin

1

1

High-throughput

0.479

High

989720

IFM3
Interferon-induced transmembrane protein 3

1

5

High-throughput

0.479

High

989721

KIF23
Kinesin-like protein KIF23

1

15

High-throughput

0.479

High

989725

B2CL1
Bcl-2-like protein 1

1

1

High-throughput

0.479

High

989726

CD47
Leukocyte surface antigen CD47

1

1

Small-scale

0.479

High

989727

TFCP2
Alpha-globin transcription factor CP2

1

7

High-throughput

0.479

High

989729

STK3
Serine/threonine-protein kinase 3

1

5

High-throughput

0.479

High

989730

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

989731

CUL3
Cullin-3

1

2

High-throughput

0.479

High

989732

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

3

High-throughput

0.479

High

989735

TNIP1
TNFAIP3-interacting protein 1

1

11

High-throughput

0.479

High

989736

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

989737

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

989741

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.479

High

989743

DUS6
Dual specificity protein phosphatase 6

1

14

High-throughput

0.479

High

989744

MIDN
Midnolin

1

3

High-throughput

0.479

High

989748

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

989750

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

989751

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

989752

TM11B
Transmembrane protease serine 11B

1

4

High-throughput

0.479

High

989754

PIM3
Serine/threonine-protein kinase pim-3

1

6

High-throughput

0.479

High

989755

TAXB1
Tax1-binding protein 1

1

6

High-throughput

0.479

High

989756

CMIP
C-Maf-inducing protein

1

2

High-throughput

0.479

High

989760

ARRD4
Arrestin domain-containing protein 4

1

2

High-throughput

0.479

High

989761

THOC2
THO complex subunit 2

1

5

High-throughput

0.479

High

989762

TBCK
TBC domain-containing protein kinase-like protein

1

5

High-throughput

0.479

High

989763

HASP
Serine/threonine-protein kinase haspin

1

5

High-throughput

0.479

High

989765

CLC4D
C-type lectin domain family 4 member D

1

4

High-throughput

0.479

High

989767

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

989768

CDKL2
Cyclin-dependent kinase-like 2

1

1

High-throughput

0.479

High

989771

CERS2
Ceramide synthase 2

1

3

High-throughput

0.479

High

989773

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.479

High

989774

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

989782

FACD2
Fanconi anemia group D2 protein

1

7

High-throughput

0.479

High

989783

ACE2
Angiotensin-converting enzyme 2

1

3

High-throughput

0.479

High

989785

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.479

High

989786

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

2

High-throughput

0.479

High

989787

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.479

High

989788

CHM4B
Charged multivesicular body protein 4b

1

6

High-throughput

0.479

High

989789

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

989790

PKHA4
Pleckstrin homology domain-containing family A member 4

1

12

High-throughput

0.479

High

989792

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

989796

NMRL1
NmrA-like family domain-containing protein 1

1

3

High-throughput

0.479

High

989802

TMPS4
Transmembrane protease serine 4

1

4

High-throughput

0.479

High

989804

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

989807

RNF12
E3 ubiquitin-protein ligase RLIM

1

6

High-throughput

0.479

High

989811

PAK5
Serine/threonine-protein kinase PAK 5

1

13

High-throughput

0.479

High

989812

HDAC6
Protein deacetylase HDAC6

1

6

High-throughput

0.479

High

989813

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

989815

UBQL2
Ubiquilin-2

1

3

High-throughput

0.479

High

989816

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

20

High-throughput

0.479

High

989817

CLC4E
C-type lectin domain family 4 member E

1

4

High-throughput

0.479

High

989818

FZR1
Fizzy-related protein homolog

1

6

High-throughput

0.479

High

989819

CHIP
E3 ubiquitin-protein ligase CHIP

1

2

Small-scale

0.479

High

989822

MB212
Protein mab-21-like 2

1

1

High-throughput

0.479

High

172678

XPO1
Exportin-1

1

0

High-throughput

0.458

High

251208

RNBP6
Ran-binding protein 6

1

0

High-throughput

0.458

High

315425

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

319644

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

413577

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

869841

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

0

High-throughput

0.458

High

946482

YBEY
Endoribonuclease YbeY

1

0

High-throughput

0.458

High

979467

H4
Histone H4

1

0

High-throughput

0.458

High

989718

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.458

High

989749

TF2H5
General transcription factor IIH subunit 5

1

0

High-throughput

0.458

High

989769

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

989781

THIC
Acetyl-CoA acetyltransferase, cytosolic

1

0

High-throughput

0.458

High

989791

ANTR1
Anthrax toxin receptor 1

1

0

Small-scale

0.458

High

989809

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.458

High

254943

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

7

High-throughput

0.445

High

337082

NPT2B
Sodium-dependent phosphate transport protein 2B

1

3

High-throughput

0.445

High

468252

HS90B
Heat shock protein HSP 90-beta

1

3

High-throughput

0.445

High

834954

S19A1
Reduced folate transporter

1

5

High-throughput

0.445

High

989734

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

10

High-throughput

0.445

High

989745

PKHA7
Pleckstrin homology domain-containing family A member 7

1

12

High-throughput

0.445

High

989753

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

1

High-throughput

0.445

High

989759

CD177
CD177 antigen

1

4

Small-scale

0.445

High

989764

CTL1
Choline transporter-like protein 1

1

5

High-throughput

0.445

High

989784

ZDHC5
Palmitoyltransferase ZDHHC5

1

3

High-throughput

0.445

High

989798

ANKH
Mineralization regulator ANKH

1

2

High-throughput

0.445

High

989799

SO1B3
Solute carrier organic anion transporter family member 1B3

1

3

High-throughput

0.445

High

989810

MTCH1
Mitochondrial carrier homolog 1

1

1

High-throughput

0.445

High

105721

APRIO
Alternative prion protein

1

5

High-throughput

0.437

High

124302

HAX1
HCLS1-associated protein X-1

1

2

High-throughput

0.437

High

166640

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

4

High-throughput

0.437

High

352389

TOP3B
DNA topoisomerase 3-beta-1

1

3

High-throughput

0.437

High

371702

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.437

High

588429

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.437

High

695166

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

767922

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

989738

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.437

High

989742

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

2

High-throughput

0.437

High

989747

MDEAS
Mitotic deacetylase-associated SANT domain protein

1

1

High-throughput

0.437

High

989797

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

8

High-throughput

0.437

High

989801

S17A5
Sialin

1

0

High-throughput

0.426

High

989778

ZBT18
Zinc finger and BTB domain-containing protein 18

1

5

High-throughput

0.407

High

989772

MSD3
Myb/SANT-like DNA-binding domain-containing protein 3

1

0

High-throughput

0.282

High

989733

TF2H3
General transcription factor IIH subunit 3

1

0

High-throughput

0.279

Low

353228

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

774995

FUS
RNA-binding protein FUS

1

0

High-throughput

0.249

Low

793685

ETFB
Electron transfer flavoprotein subunit beta

1

0

High-throughput

0.249

Low

989746

FBX42
F-box only protein 42

1

0

High-throughput

0.249

Low

989758

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025