HitPredict

Interactor 1: VATB1 (P15313)
V-type proton ATPase subunit B, kidney isoform (V-ATPase subunit B 1) (Endomembrane proton pump 58 kDa subunit) (Vacuolar proton pump subunit B 1)
Gene: ATP6V1B1

Interactor 2: VATE2 (Q96A05)
V-type proton ATPase subunit E 2 (V-ATPase subunit E 2) (Vacuolar proton pump subunit E 2)
Gene: ATP6V1E2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	ATP-synt_ab~vATP-synt_E, ATP-synt_ab_N~vATP-synt_E
Common GO terms	GO:0005829 - cytosol GO:0016241 - regulation of macroautophagy GO:0046961 - proton-transporting ATPase activity, rotational mechanism
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 513 Hs			1 226
+	Hs
		547315 VATB1_HUMAN (1-513): 0: 650: 100.00		VATE1_HUMAN (1-225): 3.66e-98: 286: 76.89
+	Mm
		840099 VATB1_MOUSE (1-513): 0: 646: 93.76		VATE1_MOUSE (1-225): 4.19e-97: 284: 77.78
+	Hs
		597644 VATB2_HUMAN (21-503): 0: 594: 88.61		VATE1_HUMAN (1-225): 3.66e-98: 286: 76.89
+	Dm
		680128 VATB_DROME (21-502): 0: 597: 86.54		VATE_DROME (1-224): 4.6e-94: 276: 61.16
+	Hs
		597689 VATB2_HUMAN (21-503): 0: 594: 88.61		VATE2_HUMAN (1-226): 5.41e-90: 266: 100.00
+	Sc
		555814 VATB_YEAST (17-498): 0: 581: 76.97		VATE_YEAST (2-225): 2.38e-76: 231: 35.40