HitPredict

Interactor 1: UCHL3 (P15374)
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UCH-L3) (EC 3.4.19.12) (Ubiquitin thioesterase L3)
Gene: UCHL3

Interactor 2: TRI63 (Q969Q1)
E3 ubiquitin-protein ligase TRIM63 (EC 2.3.2.27) (Iris RING finger protein) (Muscle-specific RING finger protein 1) (MuRF-1) (MuRF1) (RING finger protein 28) (RING-type E3 ubiquitin transferase TRIM63) (Striated muscle RING zinc finger protein) (Tripartite motif-containing protein 63)
Gene: TRIM63

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	31391242, 22626734
Identification Methods	two hybrid, enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 230 Hs			1 353
+	Hs
		548123 UCHL3_HUMAN (1-230): 3.13e-113: 325: 100.00		TRI54_HUMAN (7-326): 7.72e-74: 234: 61.37
+	Hs
		548124 UCHL3_HUMAN (1-230): 3.13e-113: 325: 100.00		TRI55_HUMAN (11-324): 8.5e-72: 234: 61.78
+	Hs
		536719 UCHL3_HUMAN (1-230): 3.13e-113: 325: 100.00		TRI27_HUMAN (8-353): 1.89e-68: 225: 17.49
+	Hs
		1282081 UCHL5_HUMAN (1-228): 9.01e-96: 284: 28.09		TRI63_HUMAN (1-326): 8.01e-81: 252: 100.00
+	Hs
		456621 UCHL1_HUMAN (8-230): 2.97e-91: 269: 55.16		TRI63_HUMAN (1-326): 8.01e-81: 252: 100.00
+	Hs
		1317499 UCHL5_HUMAN (1-228): 9.01e-96: 284: 28.09		TRI54_HUMAN (7-326): 7.72e-74: 234: 61.37
+	Hs
		1317550 UCHL5_HUMAN (1-228): 9.01e-96: 284: 28.09		TRI55_HUMAN (11-324): 8.5e-72: 234: 61.78
+	Hs
		1267066 BAP1_HUMAN (3-228): 3.37e-82: 261: 24.07		TRI63_HUMAN (1-326): 8.01e-81: 252: 100.00
+	Hs
		456497 UCHL1_HUMAN (8-230): 2.97e-91: 269: 55.16		RO52_HUMAN (8-353): 2.82e-75: 241: 14.74
+	Hs
		537150 UCHL5_HUMAN (1-228): 9.01e-96: 284: 28.09		TRI27_HUMAN (8-353): 1.89e-68: 225: 17.49
+	Hs
		456641 UCHL1_HUMAN (8-230): 2.97e-91: 269: 55.16		TRI54_HUMAN (7-326): 7.72e-74: 234: 61.37
+	Hs
		585024 BAP1_HUMAN (3-228): 3.37e-82: 261: 24.07		RO52_HUMAN (8-353): 2.82e-75: 241: 14.74
+	Hs
		1190465 UCHL5_HUMAN (1-228): 9.01e-96: 284: 28.09		TRI46_HUMAN (6-344): 4.56e-63: 215: 23.91
+	Hs
		175701 BAP1_HUMAN (3-228): 3.37e-82: 261: 24.07		TRI18_HUMAN (43-337): 4.87e-65: 219: 23.65
+	Hs
		548108 UCHL3_HUMAN (1-230): 3.13e-113: 325: 100.00		TRI67_HUMAN (75-147): 2.92e-12: 69.8: 29.49
+	Hs
		1172444 UCHL5_HUMAN (1-228): 9.01e-96: 284: 28.09		TRI67_HUMAN (75-147): 2.92e-12: 69.8: 29.49
+	Hs
		456595 UCHL1_HUMAN (8-230): 2.97e-91: 269: 55.16		TRI67_HUMAN (75-147): 2.92e-12: 69.8: 29.49
+	Hs
		1171040 BAP1_HUMAN (3-228): 3.37e-82: 261: 24.07		TRI67_HUMAN (75-147): 2.92e-12: 69.8: 29.49