Protein: NEDD4
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)

Gene: NEDD4
Organism: Mus musculus
Interactions: 61
UniProt ID: P46935

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000151 - ubiquitin ligase complex
GO:0000785 - chromatin
GO:0002250 - adaptive immune response
GO:0003151 - outflow tract morphogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

861873

GRB10
Growth factor receptor-bound protein 10

2

17

Small-scale

0.843

High

861891

NFIP1
NEDD4 family-interacting protein 1

4

17

Small-scale

0.694

High

861870

AGAP2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

1

3

High-throughput

0.691

High

861871

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

9

High-throughput

0.691

High

861878

SCNNA
Epithelial sodium channel subunit alpha

3

20

Small-scale

0.651

High

861905

SCNNB
Epithelial sodium channel subunit beta

3

20

Small-scale

0.651

High

861862

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

14

Small-scale

0.647

High

861864

DLG3
Disks large homolog 3

1

10

Small-scale

0.618

High

861865

TNIK
Traf2 and NCK-interacting protein kinase

2

20

Small-scale

0.611

High

861906

SCNNG
Epithelial sodium channel subunit gamma

2

20

Small-scale

0.602

High

861895

1433B
14-3-3 protein beta/alpha

2

20

Small-scale

0.584

High

861867

WBP2
WW domain-binding protein 2

1

11

Small-scale

0.561

High

861884

Q6P8P8
Surfactant protein C

1

4

Small-scale

0.561

High

861892

TMG2
Transmembrane gamma-carboxyglutamic acid protein 2

1

14

Small-scale

0.561

High

861894

ARBK1
Beta-adrenergic receptor kinase 1

1

16

Small-scale

0.561

High

861902

LITAF
Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog

1

8

Small-scale

0.561

High

861903

RNF11
RING finger protein 11

1

15

Small-scale

0.561

High

861899

BEAN1
Protein BEAN1

1

0

Small-scale

0.537

High

861879

FXR1
RNA-binding protein FXR1

1

8

High-throughput

0.536

High

861898

TSC1
Hamartin

1

6

High-throughput

0.536

High

861877

LAPM5
Lysosomal-associated transmembrane protein 5

1

7

Small-scale

0.527

High

861866

WBP1
WW domain-binding protein 1

1

10

Small-scale

0.512

High

73088

SCN2A
Sodium channel protein type 2 subunit alpha

1

20

Small-scale

0.501

High

312721

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

10

Small-scale

0.501

High

861869

Q3UF73
Ion transport domain-containing protein

1

20

Small-scale

0.501

High

861880

SCN9A
Sodium channel protein type 9 subunit alpha

1

20

Small-scale

0.501

High

861883

N4BP1
NEDD4-binding protein 1

1

2

Small-scale

0.501

High

861885

SCNAA
Sodium channel protein type 10 subunit alpha

1

20

Small-scale

0.501

High

861901

SCN5A
Sodium channel protein type 5 subunit alpha

1

20

Small-scale

0.501

High

861904

SCN8A
Sodium channel protein type 8 subunit alpha

1

20

Small-scale

0.501

High

236882

ACK1
Activated CDC42 kinase 1

1

20

Small-scale

0.479

High

629200

PO5F1
POU domain, class 5, transcription factor 1

1

4

High-throughput

0.479

High

651492

CBL
E3 ubiquitin-protein ligase CBL

1

13

Small-scale

0.479

High

660931

IRF8
Interferon regulatory factor 8

1

2

High-throughput

0.479

High

693156

TNR5
Tumor necrosis factor receptor superfamily member 5

1

8

Small-scale

0.479

High

789686

PPARG
Peroxisome proliferator-activated receptor gamma

1

11

Small-scale

0.479

High

811895

TRAF2
TNF receptor-associated factor 2

1

13

Small-scale

0.479

High

861863

1433E
14-3-3 protein epsilon

1

12

Small-scale

0.479

High

861868

RUNX2
Runt-related transcription factor 2

1

11

Small-scale

0.479

High

861872

SPDYA
Speedy protein A

1

1

Small-scale

0.479

High

861874

NF2L2
Nuclear factor erythroid 2-related factor 2

1

12

Small-scale

0.479

High

861875

TRAF3
TNF receptor-associated factor 3

1

20

Small-scale

0.479

High

861876

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

6

Small-scale

0.479

High

861881

ZBT7B
Zinc finger and BTB domain-containing protein 7B

1

4

Small-scale

0.479

High

861882

SQSTM
Sequestosome-1

1

5

Small-scale

0.479

High

861886

GPBAR
G-protein coupled bile acid receptor 1

1

1

Small-scale

0.479

High

861887

FACD2
Fanconi anemia group D2 protein homolog

1

2

High-throughput

0.479

High

861888

RAP2A
Ras-related protein Rap-2a

1

5

Small-scale

0.479

High

861889

Q8BPK8
Fragile X messenger ribonucleoprotein 1

1

8

High-throughput

0.479

High

861893

EED
Polycomb protein EED

1

7

High-throughput

0.479

High

861896

ATAD1
Outer mitochondrial transmembrane helix translocase

1

11

Small-scale

0.479

High

861900

RBCC1
RB1-inducible coiled-coil protein 1

1

9

Small-scale

0.479

High

861907

AICDA
Single-stranded DNA cytosine deaminase

1

2

Small-scale

0.479

High

861897

PMEPA
Protein TMEPAI

1

12

Small-scale

0.470

High

861890

FNDC5
Fibronectin type III domain-containing protein 5

1

0

High-throughput

0.458

High

59719

A2APF4
Prostate transmembrane protein, androgen induced 1

1

12

Small-scale

0.457

High

777834

FMR1
Fragile X messenger ribonucleoprotein 1

1

8

High-throughput

0.445

High

313086

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

16

Small-scale

0.439

High

398156

CFAD
Complement factor D

1

3

High-throughput

0.437

High

551389

A4
Amyloid-beta precursor protein

1

4

Small-scale

0.408

High


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Last updated: 11Aug2025