HitPredict

Interactor 1: FOSL1 (P15407)
Fos-related antigen 1 (FRA-1)
Gene: FOSL1

Interactor 2: EP300 (Q09472)
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
Gene: EP300

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	17882273, 21937452
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 271 Hs			1 2414
+	Hs
		547790 ATF2_HUMAN (12-236): 3.11e-29: 117: 22.50		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		345411 FOS_HUMAN (12-261): 4.65e-28: 112: 34.85		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Mm
		70880 XBP1_MOUSE (61-268): 5.82e-34: 125: 21.53		EP300_MOUSE (1-2414): 0: 1090: 93.01
+	Hs
		566753 JUNB_HUMAN (17-181): 3.32e-23: 98.6: 17.92		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		862616 FOSB_HUMAN (12-271): 4.27e-23: 98.2: 34.70		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Hs
		548300 FOSL2_HUMAN (1-271): 5.84e-22: 95.1: 40.18		EP300_HUMAN (1-2414): 0: 1113: 100.00
+	Mm
		70887 JUN_MOUSE (1-174): 1.39e-22: 96.6: 19.43		EP300_MOUSE (1-2414): 0: 1090: 93.01
+	Mm
		70890 ATF2_MOUSE (12-246): 7.87e-22: 96.2: 20.57		EP300_MOUSE (1-2414): 0: 1090: 93.01
+	Hs
		345594 FOS_HUMAN (12-261): 4.65e-28: 112: 34.85		NCOA3_HUMAN (1849-2386): 7.64e-52: 204: 21.89
+	Hs
		345579 FOS_HUMAN (12-261): 4.65e-28: 112: 34.85		TRI33_HUMAN (604-1201): 1.37e-44: 180: 14.50
+	Hs
		548258 FOSL1_HUMAN (1-271): 6.28e-46: 157: 100.00		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Hs
		547833 ATF2_HUMAN (12-236): 3.11e-29: 117: 22.50		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Hs
		345491 FOS_HUMAN (12-261): 4.65e-28: 112: 34.85		KMT2C_HUMAN (416-1078): 1.02e-10: 70.1: 11.13
+	Hs
		345480 FOS_HUMAN (12-261): 4.65e-28: 112: 34.85		PB1_HUMAN (1081-1145): 9.68e-11: 69.8: 36.92
+	Hs
		345507 FOS_HUMAN (12-261): 4.65e-28: 112: 34.85		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Hs
		579220 ATF3_HUMAN (99-184): 1.88e-26: 103: 45.35		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Hs
		566778 JUNB_HUMAN (17-181): 3.32e-23: 98.6: 17.92		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Hs
		862628 FOSB_HUMAN (12-271): 4.27e-23: 98.2: 34.70		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Hs
		974401 CREM_HUMAN (3-156): 1.11e-22: 97: 19.48		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25
+	Hs
		579154 ATF1_HUMAN (11-156): 2.41e-15: 75.8: 17.81		CBP_HUMAN (1752-2400): 4.44e-10: 67.9: 13.25