Protein: CDK8
Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (Mediator complex subunit CDK8) (Mediator of RNA polymerase II transcription subunit CDK8) (Protein kinase K35)

Gene: CDK8
Organism: Homo sapiens
Interactions: 230
UniProt ID: P49336

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004693 - cyclin-dependent protein serine/threonine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

624411

CCNC
Cyclin-C

26

20

Small-scale

0.992

High

225356

MED14
Mediator of RNA polymerase II transcription subunit 14

16

18

Small-scale

0.986

High

270486

MED6
Mediator of RNA polymerase II transcription subunit 6

16

4

Small-scale

0.985

High

826238

CDK8
Cyclin-dependent kinase 8

5

18

Small-scale

0.918

High

826350

CDK19
Cyclin-dependent kinase 19

5

18

Small-scale

0.915

High

161333

MYPT1
Protein phosphatase 1 regulatory subunit 12A

3

10

High-throughput

0.861

High

826258

CDK16
Cyclin-dependent kinase 16

3

19

High-throughput

0.861

High

826329

MED12
Mediator of RNA polymerase II transcription subunit 12

21

13

Small-scale

0.765

High

826280

MED1
Mediator of RNA polymerase II transcription subunit 1

17

10

Small-scale

0.765

High

826370

MED13
Mediator of RNA polymerase II transcription subunit 13

17

7

Small-scale

0.763

High

265313

MED24
Mediator of RNA polymerase II transcription subunit 24

15

2

Small-scale

0.762

High

826339

MED15
Mediator of RNA polymerase II transcription subunit 15

14

11

Small-scale

0.762

High

826374

MED23
Mediator of RNA polymerase II transcription subunit 23

15

3

Small-scale

0.762

High

826268

MED21
Mediator of RNA polymerase II transcription subunit 21

14

3

Small-scale

0.762

High

826364

MED17
Mediator of RNA polymerase II transcription subunit 17

14

4

Small-scale

0.761

High

826365

MED9
Mediator of RNA polymerase II transcription subunit 9

13

2

Small-scale

0.761

High

826345

MED10
Mediator of RNA polymerase II transcription subunit 10

13

3

Small-scale

0.761

High

826379

MED16
Mediator of RNA polymerase II transcription subunit 16

13

3

Small-scale

0.761

High

826361

MED4
Mediator of RNA polymerase II transcription subunit 4

11

3

High-throughput

0.759

High

826366

MED29
Mediator of RNA polymerase II transcription subunit 29

11

3

High-throughput

0.759

High

48634

MED19
Mediator of RNA polymerase II transcription subunit 19

11

2

Small-scale

0.758

High

826283

CDC37
Hsp90 co-chaperone Cdc37

3

10

High-throughput

0.758

High

826358

MED20
Mediator of RNA polymerase II transcription subunit 20

11

3

Small-scale

0.758

High

826355

MED28
Mediator of RNA polymerase II transcription subunit 28

10

2

High-throughput

0.756

High

206612

MED7
Mediator of RNA polymerase II transcription subunit 7

10

5

Small-scale

0.755

High

826297

MED27
Mediator of RNA polymerase II transcription subunit 27

9

3

High-throughput

0.754

High

826302

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

9

7

High-throughput

0.754

High

826334

MED8
Mediator of RNA polymerase II transcription subunit 8

9

3

High-throughput

0.754

High

226836

PRKN
E3 ubiquitin-protein ligase parkin

2

12

High-throughput

0.754

High

826242

CDK9
Cyclin-dependent kinase 9

2

19

Small-scale

0.754

High

826335

MED30
Mediator of RNA polymerase II transcription subunit 30

9

3

Small-scale

0.753

High

826381

MED31
Mediator of RNA polymerase II transcription subunit 31

8

4

Small-scale

0.752

High

826279

MED22
Mediator of RNA polymerase II transcription subunit 22

9

3

Small-scale

0.752

High

826303

MED25
Mediator of RNA polymerase II transcription subunit 25

10

2

Small-scale

0.751

High

826346

MED18
Mediator of RNA polymerase II transcription subunit 18

7

3

High-throughput

0.750

High

826367

MED11
Mediator of RNA polymerase II transcription subunit 11

6

2

High-throughput

0.734

High

826308

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

6

16

High-throughput

0.730

High

624806

RPB1
DNA-directed RNA polymerase II subunit RPB1

6

11

Small-scale

0.727

High

313403

MED26
Mediator of RNA polymerase II transcription subunit 26

5

1

Small-scale

0.716

High

91296

E5RFK5
Cyclin-C

2

20

High-throughput

0.712

High

826286

HS905
Putative heat shock protein HSP 90-alpha A5

2

20

High-throughput

0.712

High

160442

AURKA
Aurora kinase A

1

10

High-throughput

0.698

High

210994

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

1

16

High-throughput

0.698

High

383690

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

14

High-throughput

0.698

High

622398

CCND1
G1/S-specific cyclin-D1

1

20

High-throughput

0.698

High

738314

BMR1A
Bone morphogenetic protein receptor type-1A

1

6

High-throughput

0.698

High

826245

CCNH
Cyclin-H

1

20

Small-scale

0.692

High

441951

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

16

High-throughput

0.691

High

509550

UBL4A
Ubiquitin-like protein 4A

1

11

High-throughput

0.691

High

803433

BAG6
Large proline-rich protein BAG6

1

15

High-throughput

0.691

High

826249

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

16

High-throughput

0.691

High

826269

TRA2A
Transformer-2 protein homolog alpha

1

14

High-throughput

0.691

High

826309

RBM45
RNA-binding protein 45

1

14

High-throughput

0.691

High

826314

PPM1K
Protein phosphatase Mn(2+)-dependent 1K

1

8

High-throughput

0.691

High

826327

CELF1
CUGBP Elav-like family member 1

1

11

High-throughput

0.691

High

826348

RBM4
RNA-binding protein 4

1

17

High-throughput

0.691

High

826353

ZN350
Zinc finger protein 350

1

1

High-throughput

0.691

High

781323

BCL6
B-cell lymphoma 6 protein

1

1

Small-scale

0.647

High

236718

CCNT1
Cyclin-T1

1

20

Small-scale

0.646

High

349974

RASK
GTPase KRas

1

6

High-throughput

0.625

High

455209

PARP1
Poly [ADP-ribose] polymerase 1

2

9

Small-scale

0.624

High

826324

KAT2A
Histone acetyltransferase KAT2A

2

19

Small-scale

0.621

High

826385

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

2

3

Small-scale

0.619

High

826371

DJC12
DnaJ homolog subfamily C member 12

1

4

High-throughput

0.618

High

176140

PPM1G
Protein phosphatase 1G

1

6

High-throughput

0.618

High

550341

ZEP1
Zinc finger protein 40

1

2

High-throughput

0.618

High

575334

EGR1
Early growth response protein 1

1

2

High-throughput

0.618

High

596727

CD11B
Cyclin-dependent kinase 11B

1

19

High-throughput

0.618

High

826246

MAT1
CDK-activating kinase assembly factor MAT1

1

3

High-throughput

0.618

High

826271

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

18

Small-scale

0.618

High

826275

MDC1
Mediator of DNA damage checkpoint protein 1

1

14

High-throughput

0.618

High

826278

STK38
Serine/threonine-protein kinase 38

1

11

Small-scale

0.618

High

826336

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

8

Small-scale

0.618

High

826349

NADAP
Kanadaptin

1

5

High-throughput

0.618

High

826359

EHMT1
Histone-lysine N-methyltransferase EHMT1

1

7

High-throughput

0.618

High

826380

ZN281
Zinc finger protein 281

1

4

High-throughput

0.618

High

738945

SRBP1
Sterol regulatory element-binding protein 1

2

17

Small-scale

0.613

High

583427

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

1

High-throughput

0.611

High

826250

ZN131
Zinc finger protein 131

2

3

High-throughput

0.611

High

826332

MTBP
Mdm2-binding protein

3

1

Small-scale

0.599

High

826384

ZSC21
Zinc finger and SCAN domain-containing protein 21

1

0

High-throughput

0.586

High

612966

TCEA1
Transcription elongation factor A protein 1

2

6

Small-scale

0.585

High

266324

TAD2A
Transcriptional adapter 2-alpha

2

4

High-throughput

0.584

High

722572

T2FA
General transcription factor IIF subunit 1

2

2

Small-scale

0.584

High

826264

TP53B
TP53-binding protein 1

2

12

High-throughput

0.584

High

826325

KAT2B
Histone acetyltransferase KAT2B

2

13

Small-scale

0.584

High

826282

SMAD1
Mothers against decapentaplegic homolog 1

1

10

Small-scale

0.578

High

73026

B4DUB1
cDNA FLJ50029, highly similar to Cell division cycle 2-like protein kinase 6

1

17

High-throughput

0.575

High

153602

ANM5
Protein arginine N-methyltransferase 5

1

5

Small-scale

0.561

High

826342

MEP50
Methylosome protein WDR77

1

16

Small-scale

0.561

High

826382

TRRAP
Transformation/transcription domain-associated protein

1

4

Small-scale

0.554

High

617477

CRCM
Colorectal mutant cancer protein

1

13

High-throughput

0.541

High

819600

NRIP1
Nuclear receptor-interacting protein 1

1

0

Small-scale

0.537

High

168117

TBX3
T-box transcription factor TBX3

1

3

High-throughput

0.536

High

300409

PCF11
Pre-mRNA cleavage complex 2 protein Pcf11

1

3

High-throughput

0.536

High

319760

HERC2
E3 ubiquitin-protein ligase HERC2

1

9

High-throughput

0.536

High

564830

HMGA1
High mobility group protein HMG-I/HMG-Y

1

3

High-throughput

0.536

High

600098

TAF1
Transcription initiation factor TFIID subunit 1

1

19

High-throughput

0.536

High

727344

DEK
Protein DEK

1

1

High-throughput

0.536

High

800316

CBX5
Chromobox protein homolog 5

1

2

High-throughput

0.536

High

826262

TFCP2
Alpha-globin transcription factor CP2

1

3

High-throughput

0.536

High

826265

CBX3
Chromobox protein homolog 3

1

2

High-throughput

0.536

High

826284

HIF1A
Hypoxia-inducible factor 1-alpha

1

5

Small-scale

0.536

High

826298

FXL19
F-box/LRR-repeat protein 19

1

7

High-throughput

0.536

High

826316

GEMI5
Gem-associated protein 5

1

15

High-throughput

0.536

High

826331

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

15

High-throughput

0.536

High

826343

BUD13
BUD13 homolog

1

6

High-throughput

0.536

High

826354

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

7

High-throughput

0.536

High

826241

CEBPA
CCAAT/enhancer-binding protein alpha

1

14

High-throughput

0.527

High

164823

SC16A
Protein transport protein Sec16A

2

7

High-throughput

0.521

High

826369

MLH3
DNA mismatch repair protein Mlh3

1

0

High-throughput

0.518

High

358731

CRYAA
Alpha-crystallin A chain

1

2

High-throughput

0.515

High

826273

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

2

High-throughput

0.515

High

826326

KLK6
Kallikrein-6

1

1

High-throughput

0.515

High

297899

ST65G
STAGA complex 65 subunit gamma

1

0

High-throughput

0.513

High

558517

GCFC2
Intron Large complex component GCFC2

1

0

High-throughput

0.513

High

826304

GET4
Golgi to ER traffic protein 4 homolog

1

0

High-throughput

0.513

High

346219

MYC
Myc proto-oncogene protein

1

15

Small-scale

0.501

High

362067

MBP
Myelin basic protein

1

8

Small-scale

0.501

High

369182

ESR1
Estrogen receptor

1

20

Small-scale

0.501

High

386305

P53
Cellular tumor antigen p53

1

10

Small-scale

0.501

High

584567

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

7

Small-scale

0.501

High

826243

SMCA4
Transcription activator BRG1

1

4

Small-scale

0.501

High

826257

SMAD3
Mothers against decapentaplegic homolog 3

1

10

Small-scale

0.501

High

826277

SUZ12
Polycomb protein SUZ12

1

1

Small-scale

0.501

High

826281

SMAD2
Mothers against decapentaplegic homolog 2

1

10

Small-scale

0.501

High

826301

H32
Histone H3.2

1

7

Small-scale

0.501

High

826320

MAML1
Mastermind-like protein 1

1

6

Small-scale

0.501

High

826322

ESR2
Estrogen receptor beta

1

20

Small-scale

0.501

High

244103

BRD4
Bromodomain-containing protein 4

1

17

Small-scale

0.500

High

826260

SRBP2
Sterol regulatory element-binding protein 2

1

15

Small-scale

0.500

High

521806

CADH1
Cadherin-1

1

3

High-throughput

0.494

High

826291

DEN4C
DENN domain-containing protein 4C

1

1

High-throughput

0.489

High

826307

SRGP1
SLIT-ROBO Rho GTPase-activating protein 1

1

4

High-throughput

0.489

High

826318

LZIC
Protein LZIC

1

2

High-throughput

0.489

High

132117

PESC
Pescadillo homolog

1

1

High-throughput

0.479

High

230724

AQR
RNA helicase aquarius

1

3

High-throughput

0.479

High

274335

WDHD1
WD repeat and HMG-box DNA-binding protein 1

1

9

High-throughput

0.479

High

309288

KIF4A
Chromosome-associated kinesin KIF4A

1

3

High-throughput

0.479

High

456099

DPOLA
DNA polymerase alpha catalytic subunit

1

6

High-throughput

0.479

High

487228

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

500398

THA
Thyroid hormone receptor alpha

1

20

Small-scale

0.479

High

569378

CEBPB
CCAAT/enhancer-binding protein beta

1

14

Small-scale

0.479

High

583669

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

1

High-throughput

0.479

High

664002

T2EA
General transcription factor IIE subunit 1

1

1

High-throughput

0.479

High

664050

T2EB
Transcription initiation factor IIE subunit beta

1

1

High-throughput

0.479

High

676834

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

5

High-throughput

0.479

High

738829

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

5

High-throughput

0.479

High

794212

MSH2
DNA mismatch repair protein Msh2

1

3

High-throughput

0.479

High

826239

PRI1
DNA primase small subunit

1

1

High-throughput

0.479

High

826244

HDGF
Hepatoma-derived growth factor

1

4

High-throughput

0.479

High

826247

IMA5
Importin subunit alpha-5

1

5

High-throughput

0.479

High

826248

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

1

High-throughput

0.479

High

826251

MFAP1
Microfibrillar-associated protein 1

1

3

High-throughput

0.479

High

826253

WDR5
WD repeat-containing protein 5

1

14

High-throughput

0.479

High

826255

TCPB
T-complex protein 1 subunit beta

1

20

Small-scale

0.479

High

826256

PRKDC
DNA-dependent protein kinase catalytic subunit

1

4

Small-scale

0.479

High

826259

E2F1
Transcription factor E2F1

1

14

Small-scale

0.479

High

826261

TF3C1
General transcription factor 3C polypeptide 1

1

1

High-throughput

0.479

High

826263

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

Small-scale

0.479

High

826266

DDX10
Probable ATP-dependent RNA helicase DDX10

1

10

High-throughput

0.479

High

826267

PPIL2
RING-type E3 ubiquitin-protein ligase PPIL2

1

2

High-throughput

0.479

High

826270

NOG2
Nucleolar GTP-binding protein 2

1

2

High-throughput

0.479

High

826272

DPOA2
DNA polymerase alpha subunit B

1

1

High-throughput

0.479

High

826274

ELOA1
Elongin-A

1

7

High-throughput

0.479

High

826285

ARI4B
AT-rich interactive domain-containing protein 4B

1

10

High-throughput

0.479

High

826287

PCID2
PCI domain-containing protein 2

1

5

High-throughput

0.479

High

826288

RIF1
Telomere-associated protein RIF1

1

10

High-throughput

0.479

High

826289

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

18

High-throughput

0.479

High

826290

MYSM1
Deubiquitinase MYSM1

1

2

High-throughput

0.479

High

826293

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

2

High-throughput

0.479

High

826296

H3C
Histone H3.3C

1

7

High-throughput

0.479

High

826299

CTR9
RNA polymerase-associated protein CTR9 homolog

1

3

High-throughput

0.479

High

826300

ACD11
Acyl-CoA dehydrogenase family member 11

1

3

High-throughput

0.479

High

826305

TICRR
Treslin

1

7

Small-scale

0.479

High

826310

MGAP
MAX gene-associated protein

1

3

High-throughput

0.479

High

826311

SUGP2
SURP and G-patch domain-containing protein 2

1

3

High-throughput

0.479

High

826312

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

5

High-throughput

0.479

High

826315

PAF1
RNA polymerase II-associated factor 1 homolog

1

2

High-throughput

0.479

High

826317

PNISR
Arginine/serine-rich protein PNISR

1

6

High-throughput

0.479

High

826319

TOPB1
DNA topoisomerase 2-binding protein 1

1

6

Small-scale

0.479

High

826323

CBP
CREB-binding protein

1

12

Small-scale

0.479

High

826328

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

6

Small-scale

0.479

High

826330

FBXW7
F-box/WD repeat-containing protein 7

1

12

Small-scale

0.479

High

826338

NACC1
Nucleus accumbens-associated protein 1

1

7

High-throughput

0.479

High

826341

SMAD5
Mothers against decapentaplegic homolog 5

1

10

Small-scale

0.479

High

826344

MTA3
Metastasis-associated protein MTA3

1

7

High-throughput

0.479

High

826351

FANCJ
Fanconi anemia group J protein

1

2

High-throughput

0.479

High

826352

SKI8
Superkiller complex protein 8

1

13

High-throughput

0.479

High

826356

ESF1
ESF1 homolog

1

1

High-throughput

0.479

High

826360

SYF1
Pre-mRNA-splicing factor SYF1

1

5

High-throughput

0.479

High

826363

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

826368

BCCIP
BRCA2 and CDKN1A-interacting protein

1

2

High-throughput

0.479

High

826373

BRPF3
Bromodomain and PHD finger-containing protein 3

1

4

High-throughput

0.479

High

826375

YETS2
YEATS domain-containing protein 2

1

6

High-throughput

0.479

High

826378

TR150
Thyroid hormone receptor-associated protein 3

1

11

Small-scale

0.479

High

826383

LAS1L
Ribosomal biogenesis protein LAS1L

1

1

High-throughput

0.479

High

826386

TF3C5
General transcription factor 3C polypeptide 5

1

1

High-throughput

0.479

High

826387

TF3C3
General transcription factor 3C polypeptide 3

1

5

High-throughput

0.479

High

826388

TAF6L
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

1

2

High-throughput

0.479

High

59396

SBNO1
Protein strawberry notch homolog 1

1

0

High-throughput

0.458

High

267633

TADA3
Transcriptional adapter 3

1

0

High-throughput

0.458

High

321729

WIZ
Protein Wiz

1

0

High-throughput

0.458

High

826240

PRI2
DNA primase large subunit

1

0

High-throughput

0.458

High

826306

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.458

High

826313

ZZZ3
ZZ-type zinc finger-containing protein 3

1

0

High-throughput

0.458

High

826337

ZN830
Zinc finger protein 830

1

0

High-throughput

0.458

High

826347

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

826357

CSR2B
Cysteine-rich protein 2-binding protein

1

0

High-throughput

0.458

High

826362

MBIP1
MAP3K12-binding inhibitory protein 1

1

0

High-throughput

0.458

High

826372

TF3C4
General transcription factor 3C polypeptide 4

1

0

High-throughput

0.458

High

826376

ISY1
Pre-mRNA-splicing factor ISY1 homolog

1

0

High-throughput

0.458

High

92484

E9PGW7
Mediator of RNA polymerase II transcription subunit 22

1

3

High-throughput

0.445

High

483752

HS71A
Heat shock 70 kDa protein 1A

1

16

High-throughput

0.445

High

552209

RFA2
Replication protein A 32 kDa subunit

1

9

High-throughput

0.445

High

749223

BRCA1
Breast cancer type 1 susceptibility protein

1

15

Small-scale

0.445

High

826252

SEC13
Protein SEC13 homolog

1

14

High-throughput

0.445

High

826254

H31
Histone H3.1

1

7

High-throughput

0.445

High

826276

SMC1A
Structural maintenance of chromosomes protein 1A

1

14

Small-scale

0.445

High

826294

NIPBL
Nipped-B-like protein

1

10

Small-scale

0.445

High

826333

RBM33
RNA-binding protein 33

1

11

High-throughput

0.445

High

826377

SMC3
Structural maintenance of chromosomes protein 3

1

9

Small-scale

0.445

High

826321

NU205
Nuclear pore complex protein Nup205

1

1

High-throughput

0.437

High

484403

RPC22
Protein POLR1D, isoform 2

1

0

High-throughput

0.426

High

826340

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

508392

TOP1
DNA topoisomerase 1

1

4

Small-scale

0.408

High

520699

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

0

High-throughput

0.279

Low

826292

ZMYM4
Zinc finger MYM-type protein 4

1

0

High-throughput

0.249

Low

826295

RADX
RPA-related protein RADX

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024