HitPredict

Interactor 1: VAV (P15498)
Proto-oncogene vav
Gene: VAV1

Interactor 2: ERBB3 (P21860)
Receptor tyrosine-protein kinase erbB-3 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-3) (Tyrosine kinase-type cell surface receptor HER3)
Gene: ERBB3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.738

Property	Details
Experiments	22973453, 16273093
Identification Methods	pull down, unspecified method
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C1_1~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 845 Hs			1 1342
+	Hs
		602023 VAV3_HUMAN (1-840): 0: 601: 57.31		ERBB3_HUMAN (1-1342): 0: 1388: 100.00
+	Hs
		601970 Q96D37_HUMAN (66-845): 0: 588: 99.62		ERBB3_HUMAN (1-1342): 0: 1388: 100.00
+	Hs
		601860 VAV2_HUMAN (1-839): 0: 562: 47.14		ERBB3_HUMAN (1-1342): 0: 1388: 100.00
+	Hs
		548711 VAV_HUMAN (1-845): 0: 641: 100.00		ERBB4_HUMAN (1-1162): 0: 1152: 50.94
+	Hs
		1071026 VAV3_HUMAN (1-840): 0: 601: 57.31		ERBB4_HUMAN (1-1162): 0: 1152: 50.94
+	Hs
		383580 VAV_HUMAN (1-845): 0: 641: 100.00		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Mm
		654977 VAV_MOUSE (1-845): 0: 634: 93.14		EGFR_MOUSE (20-1145): 0: 1071: 43.44
+	Hs
		337872 VAV_HUMAN (1-845): 0: 641: 100.00		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		384022 VAV3_HUMAN (1-840): 0: 601: 57.31		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		383927 Q96D37_HUMAN (66-845): 0: 588: 99.62		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		339121 VAV3_HUMAN (1-840): 0: 601: 57.31		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		338823 Q96D37_HUMAN (66-845): 0: 588: 99.62		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		383705 VAV2_HUMAN (1-839): 0: 562: 47.14		ERBB2_HUMAN (25-1222): 0: 1067: 39.95
+	Hs
		338167 VAV2_HUMAN (1-839): 0: 562: 47.14		EGFR_HUMAN (18-1157): 0: 1041: 42.30
+	Hs
		337333 VAV_HUMAN (1-845): 0: 641: 100.00		ABL1_HUMAN (696-1307): 5.97e-133: 439: 22.51
+	Hs
		548706 VAV_HUMAN (1-845): 0: 641: 100.00		FAK2_HUMAN (673-1201): 9.77e-104: 355: 25.96
+	Hs
		435801 VAV3_HUMAN (1-840): 0: 601: 57.31		IGF1R_HUMAN (577-1061): 4.71e-104: 363: 21.00
+	Hs
		855777 VAV2_HUMAN (1-839): 0: 562: 47.14		EPHA4_HUMAN (656-996): 2.83e-103: 354: 27.79
+	Hs
		411288 VAV_HUMAN (1-845): 0: 641: 100.00		INSR_HUMAN (329-650): 2.27e-22: 106: 16.98
+	Hs
		411523 VAV3_HUMAN (1-840): 0: 601: 57.31		INSR_HUMAN (329-650): 2.27e-22: 106: 16.98