Protein: FILA
Filaggrin

Gene: FILA, FLG
Organism: Homo sapiens
Interactions: 114
UniProt ID: P20930

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0005509 - calcium ion binding
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0018149 - peptide cross-linking

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

596264

CF298
Cilia- and flagella-associated protein 298

3

0

High-throughput

0.638

High

274179

STK16
Serine/threonine-protein kinase 16

2

15

High-throughput

0.628

High

365149

FRIH
Ferritin heavy chain

2

3

High-throughput

0.628

High

427442

ANXA2
Annexin A2

1

15

High-throughput

0.618

High

596289

FILA2
Filaggrin-2

1

18

High-throughput

0.618

High

596269

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

2

1

High-throughput

0.611

High

596311

GMCL1
Germ cell-less protein-like 1

2

8

High-throughput

0.611

High

596261

UCP2
Dicarboxylate carrier SLC25A8

3

4

High-throughput

0.609

High

596280

KI3S1
Killer cell immunoglobulin-like receptor 3DS1

3

14

High-throughput

0.609

High

596253

CASPE
Caspase-14

2

4

Small-scale

0.595

High

596327

TNR19
Tumor necrosis factor receptor superfamily member 19

2

1

High-throughput

0.574

High

596277

GPR18
N-arachidonyl glycine receptor

2

6

High-throughput

0.558

High

200807

ZSC12
Zinc finger and SCAN domain-containing protein 12

2

4

High-throughput

0.552

High

596306

ESR2
Estrogen receptor beta

2

19

High-throughput

0.552

High

173555

NPHP1
Nephrocystin-1

1

1

High-throughput

0.536

High

265597

E2F6
Transcription factor E2F6

1

3

High-throughput

0.536

High

518248

ADT3
ADP/ATP translocase 3

1

1

High-throughput

0.536

High

565868

AATC
Aspartate aminotransferase, cytoplasmic

1

3

High-throughput

0.536

High

584538

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

13

High-throughput

0.536

High

596250

CCNC
Cyclin-C

1

4

High-throughput

0.536

High

596260

AF17
Protein AF-17

1

3

High-throughput

0.536

High

596262

STX17
Syntaxin-17

1

2

High-throughput

0.536

High

596263

DSCR6
Protein ripply3

1

5

High-throughput

0.536

High

596266

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

5

High-throughput

0.536

High

596272

CUL2
Cullin-2

1

9

High-throughput

0.536

High

596282

STK11
Serine/threonine-protein kinase STK11

1

2

High-throughput

0.536

High

596288

LRC10
Leucine-rich repeat-containing protein 10

1

3

High-throughput

0.536

High

596294

DPPA4
Developmental pluripotency-associated protein 4

1

1

High-throughput

0.536

High

596295

APTX
Aprataxin

1

2

High-throughput

0.536

High

596296

ZC3C1
Zinc finger C3HC-type protein 1

1

2

High-throughput

0.536

High

596323

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

4

High-throughput

0.536

High

596331

DTL
Denticleless protein homolog

1

2

High-throughput

0.536

High

296269

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

12

High-throughput

0.515

High

596276

FLNC
Filamin-C

1

8

High-throughput

0.515

High

596283

EZH2
Histone-lysine N-methyltransferase EZH2

1

8

High-throughput

0.515

High

596252

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

0

High-throughput

0.513

High

596322

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.513

High

385839

CPNS1
Calpain small subunit 1

1

3

Small-scale

0.501

High

596333

PADI1
Protein-arginine deiminase type-1

1

4

Small-scale

0.501

High

596334

PADI2
Protein-arginine deiminase type-2

1

4

Small-scale

0.501

High

596336

KLK5
Kallikrein-5

1

9

Small-scale

0.501

High

596338

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

5

Small-scale

0.501

High

274929

RENR
Renin receptor

1

3

High-throughput

0.489

High

303646

OR2A4
Olfactory receptor 2A4

1

5

High-throughput

0.489

High

596254

CCR1
C-C chemokine receptor type 1

1

5

High-throughput

0.489

High

596259

PTSS1
Phosphatidylserine synthase 1

1

4

High-throughput

0.489

High

596278

I5P1
Inositol polyphosphate-5-phosphatase A

1

2

High-throughput

0.489

High

596285

CR021
UPF0711 protein C18orf21

1

4

High-throughput

0.489

High

596292

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.489

High

596300

FRMD1
FERM domain-containing protein 1

1

8

High-throughput

0.489

High

596302

FNDC5
Fibronectin type III domain-containing protein 5

1

8

High-throughput

0.489

High

596303

O13C3
Olfactory receptor 13C3

1

1

High-throughput

0.489

High

596308

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

5

High-throughput

0.489

High

596309

SARAF
Store-operated calcium entry-associated regulatory factor

1

2

High-throughput

0.489

High

596310

ERP27
Endoplasmic reticulum resident protein 27

1

8

High-throughput

0.489

High

596312

SH23A
SH2 domain-containing protein 3A

1

11

High-throughput

0.489

High

596314

MMTA2
Multiple myeloma tumor-associated protein 2

1

3

High-throughput

0.489

High

596326

TSSP
Thymus-specific serine protease

1

1

High-throughput

0.489

High

596328

TB22B
TBC1 domain family member 22B

1

5

High-throughput

0.489

High

130737

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

6

High-throughput

0.479

High

133879

DDX3X
ATP-dependent RNA helicase DDX3X

1

8

Small-scale

0.479

High

282525

RNF8
E3 ubiquitin-protein ligase RNF8

1

11

High-throughput

0.479

High

453143

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

4

High-throughput

0.479

High

528538

CFTR
Cystic fibrosis transmembrane conductance regulator

1

8

High-throughput

0.479

High

595736

MAK
Serine/threonine-protein kinase MAK

1

13

High-throughput

0.479

High

596249

TBG1
Tubulin gamma-1 chain

1

3

High-throughput

0.479

High

596256

VHL
von Hippel-Lindau disease tumor suppressor

1

7

High-throughput

0.479

High

596265

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

596267

KIF23
Kinesin-like protein KIF23

1

11

High-throughput

0.479

High

596268

DSG1
Desmoglein-1

1

5

High-throughput

0.479

High

596270

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

5

High-throughput

0.479

High

596273

PKP1
Plakophilin-1

1

7

High-throughput

0.479

High

596274

BLMH
Bleomycin hydrolase

1

1

High-throughput

0.479

High

596279

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

10

High-throughput

0.479

High

596281

TNIP1
TNFAIP3-interacting protein 1

1

17

High-throughput

0.479

High

596286

LARP7
La-related protein 7

1

5

High-throughput

0.479

High

596293

RICTR
Rapamycin-insensitive companion of mTOR

1

2

High-throughput

0.479

High

596307

FBXW7
F-box/WD repeat-containing protein 7

1

6

High-throughput

0.479

High

596315

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

20

High-throughput

0.479

High

596319

PRD14
PR domain zinc finger protein 14

1

5

Small-scale

0.479

High

596320

ATG5
Autophagy protein 5

1

1

High-throughput

0.479

High

596321

TXNIP
Thioredoxin-interacting protein

1

12

Small-scale

0.479

High

596325

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

7

High-throughput

0.479

High

596332

ZRAN1
Ubiquitin thioesterase ZRANB1

1

14

High-throughput

0.479

High

596337

TRRAP
Transformation/transcription domain-associated protein

1

4

High-throughput

0.479

High

596251

3MG
DNA-3-methyladenine glycosylase

1

0

Small-scale

0.458

High

596313

TMM79
Transmembrane protein 79

1

0

Small-scale

0.458

High

596275

KLF5
Krueppel-like factor 5

1

11

High-throughput

0.457

High

596284

DDR2
Discoidin domain-containing receptor 2

1

11

High-throughput

0.457

High

496287

TAU
Microtubule-associated protein tau

1

14

Small-scale

0.445

High

596255

BMI1
Polycomb complex protein BMI-1

1

12

High-throughput

0.445

High

596257

PI4KA
Phosphatidylinositol 4-kinase alpha

1

9

High-throughput

0.445

High

596271

STK4
Serine/threonine-protein kinase 4

1

7

High-throughput

0.445

High

596290

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

7

High-throughput

0.445

High

596297

Q8IXN4
MAK protein

1

13

High-throughput

0.445

High

596299

SLX4
Structure-specific endonuclease subunit SLX4

1

5

High-throughput

0.445

High

596317

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

15

High-throughput

0.445

High

100473

APRIO
Alternative prion protein

1

6

High-throughput

0.437

High

548810

HIS3
Histatin-3

1

2

Small-scale

0.437

High

596287

Q4LE69
1-phosphatidylinositol 4-kinase

1

9

High-throughput

0.437

High

596316

ACE2
Angiotensin-converting enzyme 2

1

3

High-throughput

0.437

High

596318

DDX24
ATP-dependent RNA helicase DDX24

1

7

High-throughput

0.437

High

596330

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

3

High-throughput

0.437

High

596258

CNDD3
Condensin-2 complex subunit D3

1

1

High-throughput

0.407

High

596291

RNLS
Renalase

1

1

Small-scale

0.407

High

596301

PI4P1
Putative inactive phosphatidylinositol 4-kinase alpha-like protein P1

1

7

High-throughput

0.407

High

596335

FCF1
rRNA-processing protein FCF1 homolog

2

0

High-throughput

0.328

High

64048

AQ12B
Aquaporin-12B

1

0

High-throughput

0.279

Low

183019

P2RX6
P2X purinoceptor 6

1

0

High-throughput

0.279

Low

596298

S35F2
Solute carrier family 35 member F2

1

0

High-throughput

0.279

Low

596304

FIBIN
Fin bud initiation factor homolog

1

0

High-throughput

0.279

Low

596305

ZDH19
Palmitoyltransferase ZDHHC19

1

0

High-throughput

0.279

Low

596324

GALT9
Polypeptide N-acetylgalactosaminyltransferase 9

1

0

High-throughput

0.279

Low

596329

SCN3B
Sodium channel regulatory subunit beta-3

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024