Protein: SE1L1
Protein sel-1 homolog 1 (Suppressor of lin-12-like protein 1) (Sel-1L)

Gene: SE1L1, SEL1L
Organism: Homo sapiens
Interactions: 168
UniProt ID: Q9UBV2

Gene Ontology (top 5):
GO:0000836 - Hrd1p ubiquitin ligase complex
GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006641 - triglyceride metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1287463

SYVN1
E3 ubiquitin-protein ligase synoviolin

18

7

Small-scale

0.763

High

1105583

OS9
Protein OS-9

15

3

Small-scale

0.762

High

1428315

DERL2
Derlin-2

5

3

Small-scale

0.709

High

1365525

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

5

4

Small-scale

0.702

High

1388116

ERLEC
Endoplasmic reticulum lectin 1

4

4

Small-scale

0.683

High

1458787

UB2J1
Ubiquitin-conjugating enzyme E2 J1

3

7

Small-scale

0.675

High

1310039

FXRD2
FAD-dependent oxidoreductase domain-containing protein 2

4

0

Small-scale

0.674

High

1458793

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

4

0

Small-scale

0.661

High

1430995

UN93B
Protein unc-93 homolog B1

3

0

High-throughput

0.629

High

1386402

FAF2
FAS-associated factor 2

2

2

Small-scale

0.628

High

688717

NKG2D
NKG2-D type II integral membrane protein

1

9

High-throughput

0.618

High

1059331

NKG2E
NKG2-E type II integral membrane protein

1

9

High-throughput

0.618

High

1363157

CLC2B
C-type lectin domain family 2 member B

1

9

High-throughput

0.618

High

363971

EGFR
Epidermal growth factor receptor

2

9

High-throughput

0.611

High

1458731

FA8A1
Protein FAM8A1

2

0

Small-scale

0.608

High

282632

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

2

2

Small-scale

0.594

High

1396553

CALR3
Calreticulin-3

2

4

High-throughput

0.584

High

1414492

DERL1
Derlin-1

2

3

Small-scale

0.584

High

1420151

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

2

4

Small-scale

0.584

High

1448300

FBX6
F-box only protein 6

2

5

High-throughput

0.584

High

628920

TRYB2
Tryptase beta-2

2

4

High-throughput

0.574

High

1292578

AMGO3
Amphoterin-induced protein 3

2

3

High-throughput

0.574

High

1361078

CBPA5
Carboxypeptidase A5

2

2

High-throughput

0.574

High

1448142

CHSTC
Carbohydrate sulfotransferase 12

2

1

High-throughput

0.574

High

1458783

PSG8
Pregnancy-specific beta-1-glycoprotein 8

2

2

High-throughput

0.574

High

935239

TERA
Transitional endoplasmic reticulum ATPase

2

4

Small-scale

0.571

High

1458791

HYOU1
Hypoxia up-regulated protein 1

1

6

Small-scale

0.561

High

1452384

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

2

2

High-throughput

0.558

High

1431638

CHST8
Carbohydrate sulfotransferase 8

2

1

High-throughput

0.549

High

573712

ENPL
Endoplasmin

1

9

High-throughput

0.536

High

1449628

CBLN4
Cerebellin-4

1

13

High-throughput

0.536

High

1163822

PTPRO
Receptor-type tyrosine-protein phosphatase O

2

2

High-throughput

0.533

High

397136

ESR1
Estrogen receptor

2

12

High-throughput

0.521

High

762169

CNR2
Cannabinoid receptor 2

1

0

Small-scale

0.513

High

880072

DNSL1
Deoxyribonuclease-1-like 1

1

0

High-throughput

0.513

High

1136695

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

0

Small-scale

0.513

High

154900

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

1

2

High-throughput

0.489

High

251125

B4GT3
Beta-1,4-galactosyltransferase 3

1

1

High-throughput

0.489

High

380374

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

2

High-throughput

0.489

High

388674

C1QA
Complement C1q subcomponent subunit A

1

15

High-throughput

0.489

High

480458

CD48
CD48 antigen

1

2

High-throughput

0.489

High

635433

C4BPB
C4b-binding protein beta chain

1

2

High-throughput

0.489

High

647413

IDS
Iduronate 2-sulfatase

1

3

High-throughput

0.489

High

774811

TIMP3
Metalloproteinase inhibitor 3

1

10

High-throughput

0.489

High

1101321

SLAF1
Signaling lymphocytic activation molecule

1

5

High-throughput

0.489

High

1142204

P2RY6
P2Y purinoceptor 6

1

5

High-throughput

0.489

High

1157101

NTRK3
NT-3 growth factor receptor

1

17

High-throughput

0.489

High

1278888

LYZL2
Lysozyme-like protein 2

1

3

High-throughput

0.489

High

1287896

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

1

High-throughput

0.489

High

1310493

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.489

High

1359266

CA054
Uncharacterized protein C1orf54

1

1

High-throughput

0.489

High

1392018

PLPR2
Phospholipid phosphatase-related protein type 2

1

1

High-throughput

0.489

High

1428907

NYX
Nyctalopin

1

1

High-throughput

0.489

High

1435404

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.489

High

1458786

KLK5
Kallikrein-5

1

7

High-throughput

0.489

High

178429

NPC1
NPC intracellular cholesterol transporter 1

1

2

High-throughput

0.479

High

229837

CALU
Calumenin

1

1

High-throughput

0.479

High

323003

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

5

Small-scale

0.479

High

414772

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

417829

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

1

Small-scale

0.479

High

473731

ITA5
Integrin alpha-5

1

7

Small-scale

0.479

High

535632

BIP
Endoplasmic reticulum chaperone BiP

1

11

Small-scale

0.479

High

566865

PDIA4
Protein disulfide-isomerase A4

1

1

High-throughput

0.479

High

774684

BASI
Basigin

1

6

Small-scale

0.479

High

951497

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.479

High

1149266

SHH
Sonic hedgehog protein

1

1

Small-scale

0.479

High

1334609

RN149
E3 ubiquitin-protein ligase RNF149

1

6

High-throughput

0.479

High

1365075

UBXN4
UBX domain-containing protein 4

1

1

Small-scale

0.479

High

1383141

LRC59
Leucine-rich repeat-containing protein 59

1

5

High-throughput

0.479

High

1415050

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

1

4

Small-scale

0.479

High

1453827

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.479

High

1458599

HEY2
Hairy/enhancer-of-split related with YRPW motif protein 2

1

1

Small-scale

0.479

High

1458782

AMFR
E3 ubiquitin-protein ligase AMFR

1

6

Small-scale

0.479

High

1458790

LOXL2
Lysyl oxidase homolog 2

1

7

High-throughput

0.479

High

1458792

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

1

Small-scale

0.479

High

460891

CATB
Cathepsin B

1

2

High-throughput

0.470

High

48257

TM129
E3 ubiquitin-protein ligase TM129

1

0

Small-scale

0.458

High

284422

CLN5
Bis(monoacylglycero)phosphate synthase CLN5

1

0

Small-scale

0.458

High

1249293

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1385213

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

Small-scale

0.458

High

439869

INSR
Insulin receptor

1

13

High-throughput

0.457

High

465679

IGF1R
Insulin-like growth factor 1 receptor

1

14

High-throughput

0.457

High

303297

S22A5
Organic cation/carnitine transporter 2

1

4

High-throughput

0.445

High

350749

NOE2
Noelin-2

1

2

High-throughput

0.445

High

564500

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

1207906

S27A3
Long-chain fatty acid transport protein 3

1

2

High-throughput

0.445

High

1335763

MOT11
Monocarboxylate transporter 11

1

3

High-throughput

0.445

High

1039440

RL6
Large ribosomal subunit protein eL6

1

1

High-throughput

0.439

High

218912

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.437

High

294471

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.437

High

331387

KI20A
Kinesin-like protein KIF20A

1

3

High-throughput

0.437

High

412750

NTRK1
High affinity nerve growth factor receptor

1

17

High-throughput

0.437

High

431930

ITB1
Integrin beta-1

1

10

Small-scale

0.437

High

437377

K2C8
Keratin, type II cytoskeletal 8

1

3

Small-scale

0.437

High

464072

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

13

High-throughput

0.437

High

567226

PPA5
Tartrate-resistant acid phosphatase type 5

1

1

High-throughput

0.437

High

592703

ITB4
Integrin beta-4

1

12

Small-scale

0.437

High

622701

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

1

High-throughput

0.437

High

658984

PTPRE
Receptor-type tyrosine-protein phosphatase epsilon

1

2

High-throughput

0.437

High

1005207

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

1022527

VLDLR
Very low-density lipoprotein receptor

1

2

Small-scale

0.437

High

1140985

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.437

High

1207846

EPHAA
Ephrin type-A receptor 10

1

4

High-throughput

0.437

High

1229740

VIR
Protein virilizer homolog

1

2

High-throughput

0.437

High

1243905

SG11A
Sperm-associated antigen 11A

1

1

High-throughput

0.437

High

1252276

SYNE3
Nesprin-3

1

3

High-throughput

0.437

High

1255941

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.437

High

1294280

GOLI
E3 ubiquitin-protein ligase RNF130

1

7

High-throughput

0.437

High

1324193

PLD6
Mitochondrial cardiolipin hydrolase

1

1

High-throughput

0.437

High

1367495

ESR2
Estrogen receptor beta

1

12

High-throughput

0.437

High

1391827

AURKB
Aurora kinase B

1

2

High-throughput

0.437

High

1449982

T106B
Transmembrane protein 106B

1

1

High-throughput

0.437

High

1453015

TLS1
Splicing factor C9orf78

1

2

High-throughput

0.437

High

1458779

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.437

High

1458781

XPO7
Exportin-7

1

7

High-throughput

0.437

High

1458788

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.437

High

1458789

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

4

Small-scale

0.437

High

1346819

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

0

High-throughput

0.426

High

1430888

METL9
Protein-L-histidine N-pros-methyltransferase

1

0

High-throughput

0.426

High

530509

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.407

High

1060402

SLC31
Amino acid transporter heavy chain SLC3A1

1

2

High-throughput

0.407

High

1064641

SG11B
Sperm-associated antigen 11B

1

1

High-throughput

0.407

High

1158853

VACHT
Vesicular acetylcholine transporter

1

1

High-throughput

0.407

High

1199102

CTL4
Choline transporter-like protein 4

1

2

High-throughput

0.407

High

1224953

S22AA
Solute carrier family 22 member 10

1

5

High-throughput

0.407

High

1227630

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.407

High

1230851

SL9A4
Sodium/hydrogen exchanger 4

1

3

High-throughput

0.407

High

1247735

S22AP
Solute carrier family 22 member 25

1

5

High-throughput

0.407

High

1251818

S39A5
Zinc transporter ZIP5

1

3

High-throughput

0.407

High

1309771

CTL2
Choline transporter-like protein 2

1

2

High-throughput

0.407

High

1356681

S22AH
Solute carrier family 22 member 17

1

5

High-throughput

0.407

High

1400637

B3A4
Anion exchange protein 4

1

1

High-throughput

0.407

High

1417624

S4A5
Electrogenic sodium bicarbonate cotransporter 4

1

1

High-throughput

0.407

High

1458784

S22AE
Solute carrier family 22 member 14

1

5

High-throughput

0.407

High

604411

ASM
Sphingomyelin phosphodiesterase

2

0

High-throughput

0.328

High

1250925

ZPBP2
Zona pellucida-binding protein 2

2

0

High-throughput

0.328

High

1458785

RXLT1
Ribitol-5-phosphate xylosyltransferase 1

2

0

High-throughput

0.328

High

1194721

GXLT1
Glucoside xylosyltransferase 1

2

0

High-throughput

0.313

High

1390898

ASIC4
Acid-sensing ion channel 4

2

0

High-throughput

0.313

High

777251

ALS
Insulin-like growth factor-binding protein complex acid labile subunit

1

0

High-throughput

0.279

Low

914786

RM12
Large ribosomal subunit protein bL12m

1

0

High-throughput

0.279

Low

946321

NXPH1
Neurexophilin-1

1

0

High-throughput

0.279

Low

1034839

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.279

Low

1205427

DB121
Beta-defensin 121

1

0

High-throughput

0.279

Low

1219231

LIPK
Lipase member K

1

0

High-throughput

0.279

Low

1245934

BRID5
BRICHOS domain-containing protein 5

1

0

High-throughput

0.279

Low

1403681

GPHA2
Glycoprotein hormone alpha-2

1

0

High-throughput

0.279

Low

1418042

FUT8
Alpha-(1,6)-fucosyltransferase

1

0

High-throughput

0.279

Low

1433385

DPEP2
Dipeptidase 2

1

0

High-throughput

0.279

Low

1435542

SPRNG
SREBP regulating gene protein

1

0

High-throughput

0.279

Low

680755

CATS
Cathepsin S

1

0

High-throughput

0.269

Low

576694

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

0

High-throughput

0.249

Low

635223

HNF1A
Hepatocyte nuclear factor 1-alpha

1

0

Small-scale

0.249

Low

858591

SO1A2
Solute carrier organic anion transporter family member 1A2

1

0

High-throughput

0.249

Low

1179158

TECT1
Tectonic-1

1

0

High-throughput

0.249

Low

1412998

CNPY3
Protein canopy homolog 3

1

0

Small-scale

0.249

Low

2126

TVA20
T cell receptor alpha variable 20

1

0

High-throughput

0.232

Low

132929

S28A1
Sodium/nucleoside cotransporter 1

1

0

High-throughput

0.232

Low

190508

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.232

Low

845221

SATT
Neutral amino acid transporter A

1

0

High-throughput

0.232

Low

855394

5HT3A
5-hydroxytryptamine receptor 3A

1

0

High-throughput

0.232

Low

1236367

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.232

Low

1242264

NPAL3
NIPA-like protein 3

1

0

High-throughput

0.232

Low

1259250

NCKX5
Sodium/potassium/calcium exchanger 5

1

0

High-throughput

0.232

Low

1359763

S13A3
Na(+)/dicarboxylate cotransporter 3

1

0

High-throughput

0.232

Low

1417166

S12A9
Solute carrier family 12 member 9

1

0

High-throughput

0.232

Low

1452354

SC5A4
Probable glucose sensor protein SLC5A4

1

0

High-throughput

0.232

Low

1458780

S23A1
Solute carrier family 23 member 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025