HitPredict

Interactor 1: CDK4 (P11802)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: RFA1 (P27694)
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]
Gene: RPA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	20679368, 37827155
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0008284 - positive regulation of cell population proliferation
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 303 Hs			1 616
+	Hs
		667544 CDK2_HUMAN (3-301): 2.3e-144: 409: 44.22		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Hs
		443196 CDK1_HUMAN (3-300): 4.42e-129: 370: 42.24		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Hs
		695226 CDK5_HUMAN (3-301): 3.24e-123: 355: 43.09		RFA1_HUMAN (1-616): 0: 781: 100.00