HitPredict

Interactor 1: H12 (P15864)
Histone H1.2 (H1 VAR.1) (H1c)
Gene: H1-2

Interactor 2: CDK4 (P30285)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (CRK3) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	12970760
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 212 Mm			1 303
+	Rn
		413197 H1T_RAT (1-198): 4.13e-34: 122: 49.26		Q6P751_RAT (3-301): 1.24e-144: 410: 43.23
+	Hs
		559328 H13_HUMAN (1-167): 1.8e-28: 108: 83.93		CDK2_HUMAN (3-301): 3.84e-145: 411: 43.56
+	Rn
		88903 H11_RAT (1-120): 1.06e-22: 93.2: 66.39		Q6P751_RAT (3-301): 1.24e-144: 410: 43.23
+	Hs
		558990 H15_HUMAN (1-115): 1.43e-20: 87.8: 80.51		CDK2_HUMAN (3-301): 3.84e-145: 411: 43.56
+	Hs
		625377 H11_HUMAN (38-197): 2.16e-18: 81.6: 60.00		CDK2_HUMAN (3-301): 3.84e-145: 411: 43.56
+	Hs
		414717 H13_HUMAN (1-167): 1.8e-28: 108: 83.93		CDK1_HUMAN (3-300): 8.51e-130: 372: 42.24
+	Mm
		794656 H15_MOUSE (1-198): 8.14e-22: 90.9: 60.77		CDK2_MOUSE (3-301): 8.13e-136: 389: 37.32
+	Hs
		515324 H13_HUMAN (1-167): 1.8e-28: 108: 83.93		CDK4_HUMAN (1-303): 1.62e-127: 367: 94.72
+	Mm
		550489 H12_MOUSE (1-115): 8.84e-18: 80.1: 100.00		CDK2_MOUSE (3-301): 8.13e-136: 389: 37.32
+	Rn
		88899 H11_RAT (1-120): 1.06e-22: 93.2: 66.39		CDK1_RAT (3-300): 1.07e-129: 372: 42.24
+	Hs
		414716 H15_HUMAN (1-115): 1.43e-20: 87.8: 80.51		CDK1_HUMAN (3-300): 8.51e-130: 372: 42.24
+	Hs
		559654 H12_HUMAN (1-173): 5.41e-26: 101: 90.17		CDK5_HUMAN (3-301): 1.7e-124: 358: 43.75
+	Mm
		673226 H15_MOUSE (1-198): 8.14e-22: 90.9: 60.77		CDK4_MOUSE (1-303): 1.36e-127: 367: 100.00
+	Hs
		489003 H14_HUMAN (1-115): 7.27e-24: 96.3: 88.70		CDK5_HUMAN (3-301): 1.7e-124: 358: 43.75
+	Hs
		414874 H11_HUMAN (38-197): 2.16e-18: 81.6: 60.00		CDK1_HUMAN (3-300): 8.51e-130: 372: 42.24
+	Mm
		509461 H12_MOUSE (1-115): 8.84e-18: 80.1: 100.00		CDK1_MOUSE (3-300): 1.05e-128: 370: 42.24
+	Hs
		515403 H11_HUMAN (38-197): 2.16e-18: 81.6: 60.00		CDK4_HUMAN (1-303): 1.62e-127: 367: 94.72
+	Hs
		960154 H11_HUMAN (38-197): 2.16e-18: 81.6: 60.00		CDK6_HUMAN (5-298): 2.33e-127: 367: 68.48
+	Hs
		559065 H15_HUMAN (1-115): 1.43e-20: 87.8: 80.51		CDK5_HUMAN (3-301): 1.7e-124: 358: 43.75
+	Hs
		960270 H11_HUMAN (38-197): 2.16e-18: 81.6: 60.00		CDK5_HUMAN (3-301): 1.7e-124: 358: 43.75