Protein: SIR2
NAD-dependent protein deacetylase sirtuin-2 (EC 2.3.1.286) (NAD-dependent protein defatty-acylase sirtuin-2) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2) (mSIR2L2)

Gene: SIR2, Sirt2
Organism: Mus musculus
Interactions: 19
UniProt ID: Q8VDQ8

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000792 - heterochromatin
GO:0003682 - chromatin binding
GO:0003950 - NAD+ poly-ADP-ribosyltransferase activity
GO:0004407 - histone deacetylase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

237264

TLX3
T-cell leukemia homeobox protein 3

1

8

High-throughput

0.541

High

1059019

NFE2
Transcription factor NF-E2 45 kDa subunit

1

2

High-throughput

0.541

High

1222962

EWS
RNA-binding protein EWS

1

6

High-throughput

0.541

High

1353993

ZBTB3
Zinc finger and BTB domain-containing protein 3

1

11

High-throughput

0.541

High

1353995

SSBP3
Single-stranded DNA-binding protein 3

1

3

High-throughput

0.541

High

1353997

SRTD1
SERTA domain-containing protein 1

1

0

High-throughput

0.518

High

1353996

CDC20
Cell division cycle protein 20 homolog

1

8

Small-scale

0.515

High

1353998

FZR1
Fizzy-related protein homolog

1

7

Small-scale

0.515

High

63113

A5D6Q2
Nuclear receptor coactivator 3

1

13

High-throughput

0.481

High

866491

PA24A
Cytosolic phospholipase A2

1

2

Small-scale

0.479

High

908682

CCNA2
Cyclin-A2

1

3

Small-scale

0.479

High

915334

TIA1
Cytotoxic granule associated RNA binding protein TIA1

1

2

High-throughput

0.479

High

1021529

AURKA
Aurora kinase A

1

6

Small-scale

0.479

High

1247148

NEB2
Neurabin-2

1

3

High-throughput

0.479

High

1353994

EED
Polycomb protein EED

1

4

High-throughput

0.479

High

108791

G3X9H5
Huntingtin

1

0

High-throughput

0.458

High

1296161

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

0

High-throughput

0.458

High

1053218

Q05BA5
Nuclear receptor coactivator

1

12

High-throughput

0.457

High

1223675

DLG4
Disks large homolog 4

1

1

High-throughput

0.445

High


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Last updated: 11Aug2025