HitPredict

Interactor 1: H12 (P15864)
Histone H1.2 (H1 VAR.1) (H1c)
Gene: H1-2

Interactor 2: CDK2 (P97377)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2)
Gene: CDK2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.655

Property	Details
Experiments	12970760, 9281369, 22898779
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 212 Mm			1 346
+	Rn
		413197 H1T_RAT (1-198): 4.13e-34: 122: 49.26		Q6P751_RAT (1-346): 1.09e-141: 404: 83.82
+	Mm
		794656 H15_MOUSE (1-198): 8.14e-22: 90.9: 60.77		CDK2_MOUSE (1-346): 6.83e-152: 432: 100.00
+	Hs
		559328 H13_HUMAN (1-167): 1.8e-28: 108: 83.93		CDK2_HUMAN (1-346): 6.94e-142: 405: 82.95
+	Rn
		88903 H11_RAT (1-120): 1.06e-22: 93.2: 66.39		Q6P751_RAT (1-346): 1.09e-141: 404: 83.82
+	Hs
		558990 H15_HUMAN (1-115): 1.43e-20: 87.8: 80.51		CDK2_HUMAN (1-346): 6.94e-142: 405: 82.95
+	Hs
		625377 H11_HUMAN (38-197): 2.16e-18: 81.6: 60.00		CDK2_HUMAN (1-346): 6.94e-142: 405: 82.95
+	Hs
		414717 H13_HUMAN (1-167): 1.8e-28: 108: 83.93		CDK1_HUMAN (1-337): 1.36e-126: 366: 56.21
+	Hs
		559352 H13_HUMAN (1-167): 1.8e-28: 108: 83.93		CDK7_HUMAN (2-346): 1.01e-122: 358: 38.22
+	Rn
		88899 H11_RAT (1-120): 1.06e-22: 93.2: 66.39		CDK1_RAT (1-337): 1.22e-126: 366: 55.62
+	Hs
		559612 H12_HUMAN (1-173): 5.41e-26: 101: 90.17		CDK7_HUMAN (2-346): 1.01e-122: 358: 38.22
+	Hs
		559654 H12_HUMAN (1-173): 5.41e-26: 101: 90.17		CDK5_HUMAN (1-340): 1.64e-122: 355: 46.04
+	Hs
		488949 H14_HUMAN (1-115): 7.27e-24: 96.3: 88.70		CDK7_HUMAN (2-346): 1.01e-122: 358: 38.22
+	Hs
		414716 H15_HUMAN (1-115): 1.43e-20: 87.8: 80.51		CDK1_HUMAN (1-337): 1.36e-126: 366: 56.21
+	Hs
		489003 H14_HUMAN (1-115): 7.27e-24: 96.3: 88.70		CDK5_HUMAN (1-340): 1.64e-122: 355: 46.04
+	Hs
		414874 H11_HUMAN (38-197): 2.16e-18: 81.6: 60.00		CDK1_HUMAN (1-337): 1.36e-126: 366: 56.21
+	Mm
		509461 H12_MOUSE (1-115): 8.84e-18: 80.1: 100.00		CDK1_MOUSE (1-337): 8.33e-126: 364: 55.62
+	Hs
		559065 H15_HUMAN (1-115): 1.43e-20: 87.8: 80.51		CDK5_HUMAN (1-340): 1.64e-122: 355: 46.04
+	Mm
		509472 H11_MOUSE (1-121): 3.4e-17: 78.6: 65.85		CDK1_MOUSE (1-337): 8.33e-126: 364: 55.62
+	Hs
		841171 H11_HUMAN (38-197): 2.16e-18: 81.6: 60.00		CDK7_HUMAN (2-346): 1.01e-122: 358: 38.22
+	Hs
		960270 H11_HUMAN (38-197): 2.16e-18: 81.6: 60.00		CDK5_HUMAN (1-340): 1.64e-122: 355: 46.04