HitPredict - High confidence protein-protein interactions

Interactor 1: TFE2 (P15923)
Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1)
Gene: TCF3

Interactor 2: TFE2 (P15923)
Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1)
Gene: TCF3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.882

Property	Details
Experiments	28205554, 22354994, 9050988, 10915743
Identification Methods	fluorescent resonance energy transfer, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0000791 - euchromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific and 32 others more... GO:0000987 - cis-regulatory region sequence-specific DNA binding GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific GO:0002326 - B cell lineage commitment GO:0003677 - DNA binding GO:0003700 - DNA-binding transcription factor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005667 - transcription regulator complex GO:0005737 - cytoplasm GO:0006355 - regulation of DNA-templated transcription GO:0006357 - regulation of transcription by RNA polymerase II GO:0007399 - nervous system development GO:0030183 - B cell differentiation GO:0030890 - positive regulation of B cell proliferation GO:0031435 - mitogen-activated protein kinase kinase kinase binding GO:0032991 - protein-containing complex GO:0033152 - immunoglobulin V(D)J recombination GO:0042803 - protein homodimerization activity GO:0043425 - bHLH transcription factor binding GO:0045666 - positive regulation of neuron differentiation GO:0045787 - positive regulation of cell cycle GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0046982 - protein heterodimerization activity GO:0051091 - positive regulation of DNA-binding transcription factor activity GO:0061629 - RNA polymerase II-specific DNA-binding transcription factor binding GO:0070644 - vitamin D response element binding GO:0070888 - E-box binding GO:0090575 - RNA polymerase II transcription regulator complex GO:0140297 - DNA-binding transcription factor binding GO:2000045 - regulation of G1/S transition of mitotic cell cycle
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1	654
Hs

1	654

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Last updated: 15 Jul 2024