HitPredict

Interactor 1: TFE2 (P15923)
Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1)
Gene: TCF3

Interactor 2: TLE1 (Q04724)
Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1)
Gene: TLE1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.602

Property	Details
Experiments	18611861, 24596249
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005667 - transcription regulator complex GO:0140297 - DNA-binding transcription factor binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 654 Hs			1 770
+	Hs
		551507 TFE2_HUMAN (1-654): 0: 907: 100.00		TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42
+	Hs
		551124 ITF2_HUMAN (1-654): 0: 758: 50.07		TLE1_HUMAN (1-770): 0: 594: 100.00
+	Hs
		980851 HTF4_HUMAN (3-654): 0: 763: 49.35		TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42
+	Hs
		551125 ITF2_HUMAN (1-654): 0: 758: 50.07		TLE3_HUMAN (1-770): 3.93e-176: 526: 77.42
+	Hs
		551129 ITF2_HUMAN (1-654): 0: 758: 50.07		TLE5_HUMAN (1-200): 1.21e-91: 287: 64.50
+	Mm
		550260 TFE2_MOUSE (1-654): 0: 861: 82.50		TLE6_MOUSE (471-770): 9.13e-46: 174: 33.99
+	Hs
		1022858 HTF4_HUMAN (3-654): 0: 763: 49.35		STRN3_HUMAN (604-768): 2.4e-28: 123: 15.46
+	Hs
		1288259 HTF4_HUMAN (3-654): 0: 763: 49.35		SNR40_HUMAN (507-675): 1.08e-09: 62.8: 28.18