HitPredict

Interactor 1: TFE2 (P15923)
Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1)
Gene: TCF3

Interactor 2: TWST2 (Q8WVJ9)
Twist-related protein 2 (Class A basic helix-loop-helix protein 39) (bHLHa39) (Dermis-expressed protein 1) (Dermo-1)
Gene: TWIST2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.858

Property	Details
Experiments	32296183, 33961781, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, validated two hybrid, two hybrid prey pooling approach, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	HLH~HLH
Common GO terms	GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 654 Hs			1 160
+	Hs
		551530 TFE2_HUMAN (1-654): 0: 907: 100.00		TWST1_HUMAN (1-160): 1.29e-34: 121: 59.20
+	Hs
		551472 TFE2_HUMAN (1-654): 0: 907: 100.00		MYF6_HUMAN (1-137): 2.72e-29: 109: 22.86
+	Hs
		551515 TFE2_HUMAN (1-654): 0: 907: 100.00		TCF15_HUMAN (18-139): 9.34e-27: 101: 36.00
+	Hs
		526739 TFE2_HUMAN (1-654): 0: 907: 100.00		MYF5_HUMAN (3-142): 6.56e-26: 100: 24.34
+	Hs
		551521 TFE2_HUMAN (1-654): 0: 907: 100.00		NDF1_HUMAN (57-126): 5.43e-25: 99.8: 40.85
+	Hs
		551544 TFE2_HUMAN (1-654): 0: 907: 100.00		PTF1A_HUMAN (9-124): 2.39e-24: 98: 35.04
+	Hs
		238585 TFE2_HUMAN (1-654): 0: 907: 100.00		MUSC_HUMAN (3-147): 2.96e-25: 97.5: 33.33
+	Hs
		546066 TFE2_HUMAN (1-654): 0: 907: 100.00		MYOG_HUMAN (9-129): 4.19e-24: 95.3: 23.97
+	Hs
		551533 TFE2_HUMAN (1-654): 0: 907: 100.00		TAL2_HUMAN (65-133): 2.19e-25: 95.2: 48.57
+	Hs
		551565 TFE2_HUMAN (1-654): 0: 907: 100.00		NGN1_HUMAN (2-136): 1e-23: 94.5: 24.27
+	Hs
		551545 TFE2_HUMAN (1-654): 0: 907: 100.00		TCF24_HUMAN (20-159): 2.83e-24: 94.1: 23.24
+	Hs
		551490 TFE2_HUMAN (1-654): 0: 907: 100.00		HAND2_HUMAN (16-135): 2.43e-23: 93: 31.41
+	Hs
		545932 TFE2_HUMAN (1-654): 0: 907: 100.00		MYOD1_HUMAN (12-125): 3.27e-22: 92.2: 23.68
+	Hs
		551504 TFE2_HUMAN (1-654): 0: 907: 100.00		HEN1_HUMAN (41-122): 2.42e-23: 90.6: 39.29
+	Hs
		551464 TFE2_HUMAN (1-654): 0: 907: 100.00		TAL1_HUMAN (66-128): 3.43e-21: 89.5: 51.56
+	Hs
		210857 TFE2_HUMAN (1-654): 0: 907: 100.00		TCF21_HUMAN (20-147): 5.57e-22: 88.3: 32.56
+	Hs
		551547 TFE2_HUMAN (1-654): 0: 907: 100.00		SCX_HUMAN (67-133): 1.02e-21: 88.3: 54.41
+	Hs
		524532 TFE2_HUMAN (1-654): 0: 907: 100.00		LYL1_HUMAN (47-124): 8.04e-21: 87.6: 38.82
+	Hs
		551505 TFE2_HUMAN (1-654): 0: 907: 100.00		HEN2_HUMAN (7-122): 3.9e-22: 87.6: 32.33
+	Hs
		330420 TFE2_HUMAN (1-654): 0: 907: 100.00		HAND1_HUMAN (42-129): 6.27e-19: 81.4: 37.08