HitPredict

Interactor 1: MUC1 (P15941)
Mucin-1 (MUC-1) (Breast carcinoma-associated antigen DF3) (Cancer antigen 15-3) (CA 15-3) (Carcinoma-associated mucin) (Episialin) (H23AG) (Krebs von den Lungen-6) (KL-6) (PEMT) (Peanut-reactive urinary mucin) (PUM) (Polymorphic epithelial mucin) (PEM) (Tumor-associated epithelial membrane antigen) (EMA) (Tumor-associated mucin) (CD antigen CD227) [Cleaved into: Mucin-1 subunit alpha (MUC1-NT) (MUC1-alpha); Mucin-1 subunit beta (MUC1-beta) (MUC1-CT)]
Gene: MUC1

Interactor 2: ERBB4 (Q15303)
Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
Gene: ERBB4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	11278868
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1255 Hs			1 1308
+	Hs
		554266 MUC1_HUMAN (1-1255): 1.21e-135: 448: 100.00		ERBB3_HUMAN (1-1258): 0: 1094: 47.33
+	Hs
		383583 MUC1_HUMAN (1-1255): 1.21e-135: 448: 100.00		ERBB2_HUMAN (25-1272): 0: 1090: 46.29
+	Hs
		1071005 MUC4_HUMAN (296-1142): 2.14e-16: 87.5: 10.86		ERBB4_HUMAN (1-1308): 0: 1406: 100.00
+	Hs
		337875 MUC1_HUMAN (1-1255): 1.21e-135: 448: 100.00		EGFR_HUMAN (20-1286): 0: 1039: 48.70
+	Hs
		601984 MUC4_HUMAN (296-1142): 2.14e-16: 87.5: 10.86		ERBB3_HUMAN (1-1258): 0: 1094: 47.33
+	Hs
		383946 MUC4_HUMAN (296-1142): 2.14e-16: 87.5: 10.86		ERBB2_HUMAN (25-1272): 0: 1090: 46.29
+	Hs
		338149 HCFC1_HUMAN (7-1107): 6.45e-29: 128: 11.01		EGFR_HUMAN (20-1286): 0: 1039: 48.70
+	Hs
		338965 TARA_HUMAN (36-1064): 2.31e-23: 110: 8.69		EGFR_HUMAN (20-1286): 0: 1039: 48.70
+	Hs
		338878 MUC4_HUMAN (296-1142): 2.14e-16: 87.5: 10.86		EGFR_HUMAN (20-1286): 0: 1039: 48.70
+	Hs
		338874 MINT_HUMAN (22-1062): 3.99e-14: 80.1: 9.50		EGFR_HUMAN (20-1286): 0: 1039: 48.70
+	Hs
		338765 MUC16_HUMAN (6-1154): 8.49e-11: 69: 9.53		EGFR_HUMAN (20-1286): 0: 1039: 48.70
+	Hs
		339147 SRRM2_HUMAN (105-1020): 1.64e-09: 64.9: 7.41		EGFR_HUMAN (20-1286): 0: 1039: 48.70
+	Hs
		337335 MUC1_HUMAN (1-1255): 1.21e-135: 448: 100.00		ABL1_HUMAN (693-1305): 3.03e-121: 406: 25.00
+	Hs
		554283 MUC1_HUMAN (1-1255): 1.21e-135: 448: 100.00		ZAP70_HUMAN (724-967): 1.42e-54: 204: 41.63
+	Dm
		1001998 Q9VLS7_DROME (4-946): 1.2e-18: 94.7: 11.85		Q0KIF4_DROME (617-1014): 2.7e-116: 392: 30.95
+	Hs
		983695 SRRM2_HUMAN (105-1020): 1.64e-09: 64.9: 7.41		FAK1_HUMAN (703-997): 6.55e-59: 223: 39.53
+	Hs
		166504 NACAD_HUMAN (36-1074): 5.89e-09: 63: 13.06		FAK1_HUMAN (703-997): 6.55e-59: 223: 39.53
+	Rn
		94371 F1M9G7_RAT (29-1028): 5.45e-21: 102: 12.12		INSR_RAT (353-660): 1.09e-31: 137: 19.05
+	Rn
		544878 SPEG_RAT (108-1155): 1.04e-14: 82.1: 10.96		INSR_RAT (353-660): 1.09e-31: 137: 19.05
+	Rn
		88946 D4A7D6_RAT (172-1250): 5.6e-12: 72.9: 8.43		INSR_RAT (353-660): 1.09e-31: 137: 19.05