HitPredict

Interactor 1: TIMP2 (P16035)
Metalloproteinase inhibitor 2 (CSC-21K) (Tissue inhibitor of metalloproteinases 2) (TIMP-2)
Gene: TIMP2

Interactor 2: TIMP3 (P35625)
Metalloproteinase inhibitor 3 (Protein MIG-5) (Tissue inhibitor of metalloproteinases 3) (TIMP-3)
Gene: TIMP3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

The method score is based on:

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0002020 - protease binding GO:0005576 - extracellular region GO:0005615 - extracellular space GO:0008191 - metalloendopeptidase inhibitor activity GO:0009725 - response to hormone and 4 others more... GO:0031012 - extracellular matrix GO:0034097 - response to cytokine GO:0051045 - negative regulation of membrane protein ectodomain proteolysis GO:0062023 - collagen-containing extracellular matrix
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	220
Hs

1	211

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024