Protein: ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain) (BCKDE1A) (BCKDH E1-alpha)

Gene: ODBA, BCKDHA
Organism: Homo sapiens
Interactions: 119
UniProt ID: P12694

Gene Ontology (top 5):
GO:0003863 - branched-chain 2-oxo acid dehydrogenase activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0009083 - branched-chain amino acid catabolic process
GO:0016831 - carboxy-lyase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

554773

ODBB
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

6

17

Small-scale

0.953

High

554815

PPM1K
Protein phosphatase Mn(2+)-dependent 1K

6

0

High-throughput

0.701

High

446504

DPOLB
DNA polymerase beta

3

1

High-throughput

0.667

High

470829

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

13

High-throughput

0.618

High

554799

RM23
Large ribosomal subunit protein uL23m

2

2

High-throughput

0.601

High

554835

SCOT2
Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial

2

0

High-throughput

0.585

High

240615

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

554801

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

3

High-throughput

0.584

High

554832

TR61B
tRNA

2

3

High-throughput

0.571

High

554797

KIF14
Kinesin-like protein KIF14

1

4

High-throughput

0.553

High

554777

S10A4
Protein S100-A4

2

2

High-throughput

0.549

High

143538

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

2

High-throughput

0.536

High

275239

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

1

High-throughput

0.536

High

288219

KBL
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

1

3

High-throughput

0.536

High

554778

KAD4
Adenylate kinase 4, mitochondrial

1

6

High-throughput

0.536

High

554784

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

4

High-throughput

0.536

High

554785

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

1

High-throughput

0.536

High

554808

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

2

High-throughput

0.536

High

554820

DHB8
(3R)-3-hydroxyacyl-CoA dehydrogenase

1

5

High-throughput

0.536

High

554824

RT24
Small ribosomal subunit protein uS3m

1

2

High-throughput

0.536

High

554829

NPS3B
Protein NipSnap homolog 3B

1

2

High-throughput

0.536

High

554852

DIC
Mitochondrial dicarboxylate carrier

1

5

High-throughput

0.536

High

554853

NPS3A
Protein NipSnap homolog 3A

1

2

High-throughput

0.536

High

554856

DPOLL
DNA polymerase lambda

1

1

High-throughput

0.536

High

554857

AMACR
Alpha-methylacyl-CoA racemase

1

1

High-throughput

0.536

High

554862

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

2

High-throughput

0.536

High

554855

ZRAN1
Ubiquitin thioesterase ZRANB1

2

2

High-throughput

0.533

High

166616

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

10

High-throughput

0.515

High

289753

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.513

High

554800

TAZ
Tafazzin

1

0

High-throughput

0.513

High

554825

RCC1L
RCC1-like G exchanging factor-like protein

1

0

High-throughput

0.513

High

554848

RT30
Large ribosomal subunit protein mL65

1

0

High-throughput

0.513

High

69757

ZN785
Zinc finger protein 785

1

1

High-throughput

0.489

High

554121

BMP2
Bone morphogenetic protein 2

1

1

High-throughput

0.489

High

554769

HXB1
Homeobox protein Hox-B1

1

2

High-throughput

0.489

High

554774

CAH6
Carbonic anhydrase 6

1

1

High-throughput

0.489

High

554779

S10A2
Protein S100-A2

1

2

High-throughput

0.489

High

554795

CUL3
Cullin-3

1

2

High-throughput

0.489

High

554834

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

1

High-throughput

0.489

High

554851

HDAC6
Protein deacetylase HDAC6

1

2

High-throughput

0.489

High

279633

CISY
Citrate synthase, mitochondrial

1

6

High-throughput

0.479

High

281868

MPPB
Mitochondrial-processing peptidase subunit beta

1

13

High-throughput

0.479

High

283781

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

1

High-throughput

0.479

High

287230

RF1M
Peptide chain release factor 1, mitochondrial

1

9

High-throughput

0.479

High

532320

CH60
60 kDa heat shock protein, mitochondrial

1

8

High-throughput

0.479

High

554776

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

8

High-throughput

0.479

High

554782

PHB1
Prohibitin 1

1

2

High-throughput

0.479

High

554794

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

7

High-throughput

0.479

High

554796

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

12

High-throughput

0.479

High

554798

PDK1
[Pyruvate dehydrogenase

1

10

High-throughput

0.479

High

554803

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

2

High-throughput

0.479

High

554804

SYAM
Alanine--tRNA ligase, mitochondrial

1

5

High-throughput

0.479

High

554807

MRM1
rRNA methyltransferase 1, mitochondrial

1

3

High-throughput

0.479

High

554816

SPT20
Spermatogenesis-associated protein 20

1

1

High-throughput

0.479

High

554818

SPRY4
SPRY domain-containing protein 4

1

1

High-throughput

0.479

High

554827

IMP2L
Mitochondrial inner membrane protease subunit 2

1

2

High-throughput

0.479

High

554830

DHRS4
Dehydrogenase/reductase SDR family member 4

1

1

High-throughput

0.479

High

554833

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

3

High-throughput

0.479

High

554836

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

4

High-throughput

0.479

High

554843

MET17
Ribosome assembly protein METTL17, mitochondrial

1

3

High-throughput

0.479

High

554844

CQ10B
Coenzyme Q-binding protein COQ10 homolog B, mitochondrial

1

1

High-throughput

0.479

High

554846

SUCHY
Succinyl-CoA:glutarate CoA-transferase

1

1

High-throughput

0.479

High

554849

WWOX
WW domain-containing oxidoreductase

1

4

High-throughput

0.479

High

554850

NDUF4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

1

1

High-throughput

0.479

High

554854

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

9

High-throughput

0.479

High

554860

HECD1
E3 ubiquitin-protein ligase HECTD1

1

3

High-throughput

0.479

High

554817

NSUN6
tRNA

1

1

High-throughput

0.470

High

505409

CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

1

0

High-throughput

0.458

High

554823

F136A
Protein FAM136A

1

0

High-throughput

0.458

High

554847

LYRM4
LYR motif-containing protein 4

1

0

High-throughput

0.458

High

554863

COQ6
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

1

0

High-throughput

0.458

High

554864

BOLA1
BolA-like protein 1

1

0

High-throughput

0.458

High

554770

PGFRA
Platelet-derived growth factor receptor alpha

1

1

High-throughput

0.457

High

554780

EPHA3
Ephrin type-A receptor 3

1

1

High-throughput

0.457

High

554793

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

6

High-throughput

0.457

High

554812

RM41
Large ribosomal subunit protein mL41

1

1

High-throughput

0.445

High

554866

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

3

High-throughput

0.445

High

342095

BRD1
Bromodomain-containing protein 1

1

2

High-throughput

0.437

High

554772

EPHA1
Ephrin type-A receptor 1

1

1

High-throughput

0.437

High

554775

SP100
Nuclear autoantigen Sp-100

1

4

High-throughput

0.437

High

554781

LTK
Leukocyte tyrosine kinase receptor

1

8

High-throughput

0.437

High

554786

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

554788

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

4

High-throughput

0.437

High

554790

DJB13
DnaJ homolog subfamily B member 13

1

4

High-throughput

0.437

High

554791

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

Small-scale

0.437

High

554792

1433Z
14-3-3 protein zeta/delta

1

1

High-throughput

0.437

High

554805

TENS2
Tensin-2

1

2

High-throughput

0.437

High

554809

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

554826

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.437

High

554837

SPRTN
DNA-dependent metalloprotease SPRTN

1

1

High-throughput

0.437

High

554842

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

554859

BRPF3
Bromodomain and PHD finger-containing protein 3

1

2

High-throughput

0.437

High

554861

TRI33
E3 ubiquitin-protein ligase TRIM33

1

3

High-throughput

0.437

High

554841

GCP60
Golgi resident protein GCP60

1

0

Small-scale

0.426

High

554858

MRM2
rRNA methyltransferase 2, mitochondrial

1

0

High-throughput

0.426

High

327768

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

1

High-throughput

0.407

High

554806

CP135
Centrosomal protein of 135 kDa

1

8

High-throughput

0.407

High

554838

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

1

High-throughput

0.407

High

554811

TMM25
Transmembrane protein 25

2

0

High-throughput

0.313

High

554865

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

2

0

High-throughput

0.313

High

377104

GLHA
Glycoprotein hormones alpha chain

1

0

High-throughput

0.279

Low

554771

PACA
Pituitary adenylate cyclase-activating polypeptide

1

0

High-throughput

0.279

Low

554787

CDK8
Cyclin-dependent kinase 8

1

0

High-throughput

0.279

Low

554813

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

0

High-throughput

0.279

Low

554814

ZN444
Zinc finger protein 444

1

0

High-throughput

0.279

Low

554822

TRI43
Tripartite motif-containing protein 43

1

0

High-throughput

0.279

Low

554828

TCF25
Ribosome quality control complex subunit TCF25

1

0

High-throughput

0.279

Low

554831

ZSA5A
Zinc finger and SCAN domain-containing protein 5A

1

0

High-throughput

0.279

Low

554839

ZBP1
Z-DNA-binding protein 1

1

0

High-throughput

0.279

Low

554840

IL25
Interleukin-25

1

0

High-throughput

0.279

Low

554789

MANF
Mesencephalic astrocyte-derived neurotrophic factor

1

0

High-throughput

0.269

Low

554783

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

554819

PHIP
PH-interacting protein

1

0

High-throughput

0.249

Low

554821

ATOH1
Transcription factor ATOH1

1

0

Small-scale

0.249

Low

219430

S26A4
Pendrin

1

0

High-throughput

0.232

Low

231791

MFS11
UNC93-like protein MFSD11

1

0

High-throughput

0.232

Low

554802

CTL4
Choline transporter-like protein 4

1

0

High-throughput

0.232

Low

554810

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

0

High-throughput

0.232

Low

554845

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025