HitPredict

Interactor 1: H2AX (P16104)
Histone H2AX (H2a/x) (Histone H2A.X)
Gene: H2AX

Interactor 2: BMI1 (P35226)
Polycomb complex protein BMI-1 (Polycomb group RING finger protein 4) (RING finger protein 51)
Gene: BMI1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.806

Property	Details
Experiments	21676867, 27108688
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Histone~zf-C3HC4_2
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 143 Hs			1 326
+	Hs
		391572 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00
+	Hs
		470285 H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47		BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00
+	Hs
		717932 H2A2A_HUMAN (1-129): 7e-66: 197: 91.47		BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00
+	Hs
		717876 H2A2C_HUMAN (1-129): 5.09e-65: 195: 90.70		BMI1_HUMAN (1-326): 1.43e-153: 435: 100.00
+	Hs
		555627 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		PCGF1_HUMAN (2-229): 5.96e-62: 199: 36.33
+	Hs
		391879 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		PCGF1_HUMAN (2-229): 5.96e-62: 199: 36.33
+	Hs
		470533 H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47		PCGF1_HUMAN (2-229): 5.96e-62: 199: 36.33
+	Hs
		555611 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Hs
		1216249 H2A2B_HUMAN (1-128): 3.43e-66: 198: 92.97		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Hs
		1151374 H2A2A_HUMAN (1-129): 7e-66: 197: 91.47		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Hs
		1185208 H2A3_HUMAN (1-129): 5.88e-66: 197: 91.47		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Hs
		391856 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Hs
		470514 H2A1_HUMAN (1-129): 7.56e-66: 197: 91.47		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Hs
		1087089 H2A2C_HUMAN (1-129): 5.09e-65: 195: 90.70		RING2_HUMAN (7-227): 8.37e-50: 170: 16.61
+	Hs
		555425 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		RING1_HUMAN (7-115): 2.38e-30: 120: 25.46
+	Mm
		1145461 H2A2C_MOUSE (1-129): 5.09e-65: 195: 90.70		CHFR_MOUSE (6-167): 1.07e-33: 132: 19.39
+	Hs
		391666 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		RING1_HUMAN (7-115): 2.38e-30: 120: 25.46
+	Hs
		282515 H2AX_HUMAN (1-143): 3.71e-74: 219: 100.00		RNF8_HUMAN (2-101): 3.38e-21: 95.7: 25.00
+	Hs
		282470 H2A1B_HUMAN (1-129): 8.35e-66: 197: 90.70		RNF8_HUMAN (2-101): 3.38e-21: 95.7: 25.00
+	Hs
		282668 H2A2C_HUMAN (1-129): 5.09e-65: 195: 90.70		RNF8_HUMAN (2-101): 3.38e-21: 95.7: 25.00